| Updated: | 25 January 2023 |
| Nextseason: | 2022–23 |
| Season: | 2021–22 |
| First Women's League of Serbia | |
| Champions: | Crvena zvezda mts |
| Runners Up: | Art Basket |
| Semifinalists: | Vojvodina 021 Kraljevo |
| Teams: | 12 |
| Duration: | 2 October 2021 – 21 April 2022 |
The 2021–22 First Women's Basketball League of Serbia (Serbian: Прва женска лига Србије 2021–22.) will be the 16th season of the First Women's Basketball League of Serbia, the highest professional basketball league in Serbia. Also, it will be the 78th national championship played by Serbian clubs inclusive of the nation's previous incarnations as Yugoslavia, Serbia and Montenegro.
Crvena zvezda mts is the defending champion.
A total of 12 teams participated in the 2021–22 First Women's Basketball League of Serbia as confirmed by the Basketball Federation of Serbia on 30 June 2021.[1]
The following is the access list for this season.
| Teams entering in this round | Teams advancing from the previous round | ||
|---|---|---|---|
| Regular season (12 teams) |
| ||
| Playoffs (4 teams) |
|
| Club[2] | City | Arena | Capacity | |
|---|---|---|---|---|
| Art Basket | Belgrade | Mega Factory | 500 | |
| Crvena zvezda mts | Belgrade | Basket City Hall | 1,600 | |
| Duga | Šabac | Šabac Gymnasium Hall | ||
| Kraljevo | Kraljevo | Kraljevo Sports Hall | 3,350 | |
| Partizan 1953 | Belgrade | Ranko Žeravica Sports Hall | 4,000 | |
| Proleter 023 | Zrenjanin | Crystal Hall | 3,000 | |
| Radivoj Korać | Belgrade | Radivoj Korać Hall | 700 | |
| Radnički | Kragujevac | Jezero Hall | 3,750 | |
| Student | Niš | Dušan Radović School Hall | 1,000 | |
| Vojvodina 021 | Novi Sad | Petrovaradin Hall | 900 | |
| Vrbas Medela | Vrbas | CFK Drago Jovović | 2,500 | |
| Vršac | Vršac | Millennium Center | 4,400 |
| Team that play in the 2021–22 Adriatic League | ||
| Team that play in the 2021–22 EuroCup Women |
The four highest-placed teams from the Regular season will qualify for the Playoffs.
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