The 2021–22 FIBA Europe Cup play-offs began on 9 March and concluded on 20 and 27 April 2022 with the 2022 FIBA Europe Cup Finals, decided the champions of the 2021–22 FIBA Europe Cup. A total of eight teams competed in the play-offs.
Each tie in the knockout phase, was played over two legs, with each team playing one leg at home.
The first legs were played on 9 and 10 March 2022, and the second legs were played on 16 March 2022.|}
The first legs were played on 30 March 2022, and the second legs were played on 6 April 2022.|}
See main article: 2022 FIBA Europe Cup Finals. The first leg was played on 20 April 2022, and the second legs was played on 27 April 2022.|}