| Club: | FC St. Gallen |
| Season: | 2021–22 |
| Chairman: | Matthias Hüppi |
| Manager: | Peter Zeidler |
| Stadium: | Kybunpark |
| League: | Swiss Super League |
| League Result: | 5th |
| Cup1: | Swiss Cup |
| Cup1 Result: | Runners-up |
| League Topscorer: | Kwadwo Duah (15) |
| Season Topscorer: | Kwadwo Duah (18) |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was FC St. Gallen's 143rd season in existence and the club's tenth consecutive season in the top flight of Swiss football. In addition to the domestic league, St. Gallen participated in this season's editions of the Swiss Cup.
See main article: 2021–22 Swiss Super League.
The league fixtures were announced on 24 June 2021.[1]
See main article: 2021–22 Swiss Cup.