| Club: | Crotone |
| Season: | 2021–22 |
| Chairman: | Gianni Vrenna |
| Mgrtitle: | Head coach |
| Manager: | Francesco Modesto (until 29 October) Pasquale Marino (from 29 October to 10 December) Francesco Modesto (from 10 December) |
| Stadium: | Stadio Ezio Scida |
| League: | Serie B |
| League Result: | 19th (relegated) |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 64 |
| League Topscorer: | Mirko Marić (11) |
| Season Topscorer: | Mirko Marić (11) |
| Pattern La1: | _crotone2122h |
| Pattern B1: | _crotone2122h |
| Pattern Ra1: | _crotone2122h |
| Pattern Sh1: | _crotone2122h |
| Pattern So1: | _crotone2122hl |
| Leftarm1: | 000040 |
| Body1: | 000040 |
| Rightarm1: | 000040 |
| Shorts1: | 000040 |
| Socks1: | 000040 |
| Pattern La2: | _crotone2122a |
| Pattern B2: | _crotone2122a |
| Pattern Ra2: | _crotone2122a |
| Pattern Sh2: | _crotone2122a |
| Pattern So2: | _crotone2122al |
| Leftarm2: | FFFFFF |
| Body2: | FFFFFF |
| Rightarm2: | FFFFFF |
| Shorts2: | FFFFFF |
| Socks2: | FFFFFF |
| Pattern La3: | _crotone2122t |
| Pattern B3: | _crotone2122t |
| Pattern Ra3: | _crotone2122t |
| Pattern Sh3: | _crotone2122t |
| Pattern So3: | _crotone2122hl |
| Leftarm3: | 4A8420 |
| Body3: | 4A8420 |
| Rightarm3: | 4A8420 |
| Shorts3: | 4A8420 |
| Socks3: | 4A8420 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was F.C. Crotone's first season back in second division of the Italian football league, the Serie B, and the 112th as a football club.
See main article: 2021–22 Serie B.
The league fixtures were announced on 24 July 2021.[2]
See main article: 2021–22 Coppa Italia.