| Club: | Espérance Sportive de Tunis |
| Season: | 2021–22 |
| Manager: | Radhi Jaïdi (until 8 June) Nabil Maâloul (from 9 June) |
| Mgrtitle: | Head coach |
| Chairman: | Hamdi Meddeb |
| Chrtitle: | President |
| Stadium: | Stade Hammadi Agrebi |
| League: | Ligue 1 |
| League Result: | Winners |
| Cup1: | Tunisian Cup |
| Cup1 Result: | Round of 16 |
| Cup2: | Super Cup |
| Cup2 Result: | 2019–20 |
| Cup3: | Champions League |
| Cup3 Result: | Quarter-finals |
| League Topscorer: | Mohamed Ali Ben Hammouda (8) |
| Season Topscorer: | Mohamed Ali Ben Hammouda (11) |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
In the 2021–22 season, Espérance Sportive de Tunis competed in the Ligue 1 for the 67th season, as well as the Tunisian Cup. It was their 67th consecutive season in the top flight of Tunisian football. They competed in Ligue 1, the Champions League, the Tunisian Cup, 2019–20 Tunisian Super Cup and the 2020–21 Tunisian Super Cup.
On the domestic front, Espérance de Tunis delivered two trophies out of possible four, winning the Ligue 1, in the last round after a late 2–1 win against US Ben Guerdane, and the 2020–21 Tunisian Super Cup, but they left the Tunisian Cup against CS M'saken after a 1–1 draw after 120 minutes and a 6–5 loss on penalties.
On the continental front, Espérance de Tunis left the Champions League from the quarter-finals after a surprise loss to ES Sétif with a score of 1–0 on aggregate.
This season was the last for the two team legends, Khalil Chemmam and Sameh Derbali, who announced their retirement at the end of the season.
Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.
Staff:
Anis Boussaïdi (assistant coach) Hamdi Kasraoui (goalkeeper coach) Sabri Bouazizi (fitness coach) Aymen Mathlouthi (fitness coach) Yassine Ben Ahmed (doctor) Lassad Lamari (physiotherapist) Nabil Ghazouani (physiotherapist) Seifeddine Dziri (physiotherapist)| Date | Name | From | Type | Source |
|---|---|---|---|---|
| 1 July 2021 | Rached Arfaoui | AS Soliman | Transfer | [1] |
| 9 August 2021 |  Anayo Iwuala | Enyimba | Transfer | [2] |
| 12 August 2021 | Zied Machmoum | US Monastir | Transfer | [3] |
| 12 August 2021 |  Percious Boah | Dreams FC | Transfer | [4] |
| 14 August 2021 |  David Koffi | AFAD Djékanou | Transfer | [5] |
| 15 September 2021 |  Moussa Konaté | Dijon | Loan | [6] |
| 7 December 2021 | Hani Amamou | CS Sfaxien | Free transfer | [7] |
| 3 January 2022 | Mohamed Ali Ben Hammouda | AS Soliman | Loan | [8] |
| 10 January 2022 |  Sabir Bougrine | Neftchi Baku | Transfer | [9] |
| 28 January 2022 | Kingsley Eduwo | Al Urooba | Free transfer | [10] |
| Date | Name | To | Type |
|---|---|---|---|
| 1 July 2021 | William Togui | Mechelen | End of loan |
| 1 July 2021 | Ibrahim Ouattara | Al Ahly Benghazi | End of contract |
| 1 July 2021 | Maher Ben Sghaïer | US Monastir | End of contract |
| 1 July 2021 | Aymen Mahmoud | Al-Arabi | End of contract |
| 1 July 2021 | Afif Jebali | Al-Mina'a | End of contract |
| 1 July 2021 | Houcine Rabii | CS Hammam-Lif | End of contract |
| 1 July 2021 | Taha Yassine Khenissi | Kuwait SC | End of contract |
| 29 July 2021 | Youssef Mosrati | AS Soliman | Loan |
| 29 July 2021 | Basit Abdul Khalid | Sheriff Tiraspol | Mutual termination |
| 1 August 2021 | Samuel Atvati | ES Métlaoui | Loan |
| 5 August 2021 | Abderrahmane Meziane | USM Alger | Mutual termination |
| 19 August 2021 | Moumen Rahmani | US Tataouine | Loan |
| 1 September 2021 | Hamdi Nagguez | Zamalek | Mutual termination |
| 1 September 2021 | Mouhib Selmi | CS Hammam-Lif | Loan |
| 8 September 2021 | Abdelraouf Benguit | MC Alger | Unilateral termination |
| 10 September 2021 | Badreddine Mouelhi | AS Soliman | Loan |
| 10 September 2021 | Hamza Ghanmi | ES Métlaoui | Loan |
| 2 October 2021 | Billel Bensaha | JS Kabylie | Transfer |
| 19 January 2022 | Percious Boah | CS Hammam-Lif | Loan |
| 28 January 2022 | Moussa Konaté | Dijon | Temination of loan |
| 31 January 2022 | Nour Beji | ES Zarzis | Loan |
| 11 March 2022 | Cedrik Gbo | OH Leuven | Loan |
| 24 March 2022 | Nassim Ben Khalifa | Sanfrecce Hiroshima | Mutual termination |
| Competition | Record | Started round | Final position / round | First match | Last match | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligue 1 | First round | Winners | 27 October 2021 | 26 June 2022 | ||||||||
| Tunisian Cup | Round of 16 | 3 June 2022 | 8 June 2022 | |||||||||
| 2019–20 Super Cup | Final | Runners–up | 18 September 2021 | |||||||||
| 2020–21 Super Cup | Final | Winners | 25 September 2021 | |||||||||
| Champions League | Second round | Quarter-finals | 17 October 2021 | 22 April 2022 | ||||||||
| Total | bgcolor=silver colspan=2 | 18 September 2021 | 26 June 2022Ligue 1See main article: 2021–22 Tunisian Ligue Professionnelle 1. First roundGroup A MatchesPlayoffMatchesResults summaryTunisian CupSee main article: 2021–22 Tunisian Cup. 2019–20 Tunisian Super CupSee main article: 2019–20 Tunisian Super Cup. 2020–21 Tunisian Super CupSee main article: 2020–21 Tunisian Super Cup. Champions LeagueSee main article: 2021–22 CAF Champions League. Qualifying roundsSee main article: 2021–22 CAF Champions League qualifying rounds. Second roundGroup stageSee main article: 2021–22 CAF Champions League group stage. Group CKnockout stageSee main article: 2021–22 CAF Champions League knockout stage. Quarter-finalsStatisticsPlaying statistics | |||||||||
