| Club: | Empoli |
| Season: | 2021–22 |
| Chrtitle: | Chairman |
| Chairman: | Fabrizio Corsi |
| Mgrtitle: | Head coach |
| Manager: | Aurelio Andreazzoli |
| Stadium: | Stadio Carlo Castellani |
| League: | Serie A |
| League Result: | 14th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Andrea Pinamonti (13) |
| Season Topscorer: | Andrea Pinamonti (13) |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 102nd season in the existence of Empoli F.C. and the club's first season back in the top flight of Italian football. In addition to the domestic league, Empoli participated in this season's edition of the Coppa Italia.
| scope=col | Player | Transferred to | scope=col; style="width: 65px;" | Fee | scope=col | Date | scope=col | Source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 31 | Cosenza | Loan | [1] |
See main article: 2021–22 Serie A.
The league fixtures were announced on 14 July 2021.[2]
See main article: 2021–22 Coppa Italia.
|-! colspan=14 style=background:#dcdcdc; text-align:center"| Goalkeepers|-! colspan=14 style=background:#dcdcdc; text-align:center"| Defenders|-! colspan=14 style=background:#dcdcdc; text-align:center"| Midfielders|-! colspan=14 style=background:#dcdcdc; text-align:center"| Forwards|-! colspan=14 style=background:#dcdcdc; text-align:center"| Players transferred out during the season