| Competition: | Damehåndboldligaen |
| Season: | 2021–22 |
| Winners: | Odense Håndbold (2nd title) |
| Relegated: | Holstebro Håndbold |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Odense Håndbold Team Esbjerg |
| Continentalcup2: | EHF European League |
| Continentalcup2 Qualifiers: | Viborg HK Ikast Håndbold Nykøbing Falster HB |
| Matches: | 232 |
| League Topscorer: |  Henny Reistad |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 Damehåndboldligaen (known as Bambusa Kvindeligaen for sponsorship reasons) was the 86th season of Damehåndboldligaen, Denmark's premier women's handball league. Odense Håndbold were the defending champions, while Ringkøbing Håndbold promoted from the 1. division.
| Team | Head coach | |
|---|---|---|
 Claus Mogensen | ||
| Jakob Andreasen | ||
| Ulrik Kirkely | ||
 Pether Krautmeyer | ||
 Jakob Larsen | ||
| Kasper Christensen | ||
| Jan Leslie |
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Mathilde Neesgaard | Aarhus United | 179 |
| 2 | 153 | ||
| 3 | Kristina Jørgensen | Viborg HK | 147 |
| 4 | Silkeborg-Voel KFUM | 143 | |
| Horsens HE | |||
| 6 | Dione Housheer | Odense Håndbold | 134 |
| 7 | Julie Holm | Ringkøbing HB | 121 |
| 8 | Eira Aune | Silkeborg-Voel KFUM | 120 |
| Melissa Petrén | København Håndbold | ||
| 10 | Emilie Ytting Pedersen | Skanderborg Håndbold | 118 |
| Sofie Bardrum | Ajax København |
| Rank | Player | Club | Goals | |
|---|---|---|---|---|
| 1 | 245 | |||
| 2 | Kristina Jørgensen | Viborg HK | 213 | |
| 3 | Dione Housheer | Odense Håndbold | 206 | |
| 4 | Mathilde Neesgaard | Aarhus United | 204 | |
| 5 | Silkeborg-Voel KFUM | 182 | ||
| 6 | Laura Damgaard | HH Elite | 180 | |
| 7 | Emma Friis | Ikast Håndbold | 162 | |
| 8 | Melissa Petrén | København Håndbold | 157 | |
| 9 | Kristine Breistøl | Team Esbjerg | 153 | |
| 10 | Line Haugsted | Viborg HK | 150 |
| Month | Player of the Month | ||
|---|---|---|---|
| Player | Club | ||
| September | Mia Rej | Odense Håndbold | |
| October | Line Haugsted | Viborg HK | |
| November | Sofie Flader | Nykøbing Falster Håndboldklub | |
| January | Eira Aune | Silkeborg-Voel KFUM | |
| February | Mathilde Neesgaard | Aarhus United Elitehandball | |
| March | Henny Reistad | Team Esbjerg | |
| April | Kristina Jørgensen | Viborg HK | |
| May | Henny Reistad | Team Esbjerg | |