| Competition: | Czech Women's First League |
| Season: | 2021–22 |
| Winners: | Slavia Prague |
| Promoted: | Baník Ostrava |
| Relegated: | Pardubice |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Slavia Prague Sparta Prague Slovácko |
| Matches: | 80 |
| Total Goals: | 350 |
| League Topscorer: | Lucie Martínková (24) |
| Longest Wins: | 18 matches |
| Longest Unbeaten: | 18 matches |
| Longest Winless: | 9 matches |
| Longest Losses: | 9 matches |
| Highest Attendance: | 500 |
| Lowest Attendance: | 20 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Updated: | 14 May 2022 |
The 2021–22 Czech Women's First League is the 29th season of the Czech Republic's top-tier football league for women. Sparta Prague are the defending champions.
The eight teams played each other twice for a total of 14 matches per team. After that the top four teams played a championship round for another six matches per team. The bottom placed four teams played the relegation round. The champions, runners-up and third-placed teams qualified for the 2022–23 UEFA Women's Champions League.
| Team | Home town | Home ground | Capacity | |
|---|---|---|---|---|
| 2,500 | ||||
| 8,150 | ||||
| Prague | 1,000 | |||
| Městský stadion | ||||
| 8,121 | ||||
| Prague | 20,000 | |||
The regular season ended on 13 March 2022.
Played by the teams placed first to fourth of the regular season. Teams play each other twice.
Played by the teams placed fifth to eighth of the regular season. Teams play each other twice.
Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.
| Team | Manager | Captain | Kit manufacturer | Shirt sponsor | |
|---|---|---|---|---|---|
| Slovan Liberec |  |  | Nike | Preciosa | |
| Dukla Prague | | | Adidas | ProInterier | |
| Slavia Prague | | | Puma | eToro | |
| Slovácko | | | Puma | Z-Group | |
| Sparta Prague | | | Adidas | ||
| Viktoria Plzeň | | | Macron | ||
| Lokomotiva Brno Horní Heršpice | | | Adidas | EXCLUSIA | |
| Pardubice | | | ČPP |
Final standing
| Rank | Scorer | Club | Goals |
|---|---|---|---|
| 1 | Lucie Martínková | Sparta Prague | 24 |
| 2 | Tereza Szewieczková | Slavia Prague | 22 |
| 3 | Michaela Dubcová | Slovácko | 15 |
| 4 | Klára Cvrčková | Sparta Prague | 12 |
| 5 | Miroslava Mrázová | Viktoria Plzeň | 11 |
| 6 | Aneta Pochmanová | Sparta Prague | 10 |