| Competition: | Prva HNLŽ |
| Season: | 2021–22 |
| Winners: | Split |
| Relegated: | Neretva |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Split |
| Biggest Home Win: | Osijek 25–0 Neretva |
| Biggest Away Win: | Neretva 0–15 Split |
| Highest Scoring: | Osijek 25–0 Neretva |
| League Topscorer: | Lorena Balić (33) |
| Matches: | 82 |
| Total Goals: | 495 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
| Updated: | 29 May 2022 |
The 2021–22 Croatian Women's First Football League (Croatian: Prva hrvatska nogometna liga za žene) was the 31st season of Croatian Women's First Football League, the national championship for women's association football teams in Croatia, since its establishment in 1992. The season started on 5 September 2021 and ended on 29 May 2022.
The league was contested by eight teams. First stage was played in a double round robin format, with each team playing every other team two times over 14 rounds. In a second stage teams were divided in two groups according to the table standings. ŽNK Osijek were the defending champions, having won their 23rd title in 2020–21.
The following is a complete list of teams who have secured a place in the 2021–22 Croatian Women's First Football League.
| Team | Location | Stadium(s) | Position in 2020–21 |
|---|---|---|---|
| Agram | Zagreb | Stadion Buzin | 4th |
| Dinamo Zagreb | Zagreb | Stadion Maksimir | 3rd |
| Donat | Zadar | Stadion Stanovi | 5th |
| Međimurje-Čakovec | Čakovec | Stadion SRC Mladost | 1st (2. HNLŽ B) |
| Neretva | Metković | Stadion Iza Vage | 6th |
| Osijek | Osijek | Mačkamama, Stadion Gradski vrt | 1st |
| Rijeka | Rijeka | Stadion Kantrida | 1st (2. HNLŽ A) |
| Split | Split | Stadion Park Mladeži | 2nd |
At the end of the season, seventh placed Donat will contest a two-legged relegation play-off tie against the losing team of promotion play-off tie between Hajduk Split and Viktorija.
Donat won 9–0 on aggregate.
Updated to matches played on 29 May 2022.[1]
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Lorena Balić | Osijek | 33 |
| 2 | Izabela Lojna | Osijek | 25 |
| 3 |  Aida Hadžić | Split | 24 |
| 4 |  Koral Hazan | Split | 21 |
| 5 | Karla Kurkutović | Dinamo Zagreb | 20 |
| 6 | Maja Joščak | Osijek | 15 |
| Sandra Žigić | Agram | ||
| 8 | Merjema Medić | Osijek | 13 |
| 9 | Petra Mikulica | Rijeka | 12 |
| 10 | Andrea Grebenar | Split | 11 |
| Ivana Stanić | Dinamo Zagreb | ||
 Ayuri Terawaki | Međimurje-Čakovec |