The 2021–22 Coupe de France preliminary rounds, Nouvelle-Aquitaine was the qualifying competition to decide which teams from the leagues of the Nouvelle-Aquitaine region of France took part in the main competition from the seventh round.
A total of thirteen teams qualified from the Nouvelle-Aquitaine preliminary rounds.[1] In 2020–21, US Lège Cap Ferret and Stade Poitevin FC progressed furthest in the main competition, reaching the round of 64 before losing to Aubagne FC and Canet Roussillon FC respectively.[2] [3]
On 13 July 2021, the league announced that a total of 689 teams had entered from the region. The first round would consist of 296 ties, featuring all teams from Régional 3 and below, plus 25 teams from Régional 2. The 45 exempted teams from Régional 2 and all 36 teams from Régional 1 entered at the second round stage. The 12 Championnat National 3 teams entered at the third round stage and the 4 Championnat National 2 teams entered at the fourth round stage.[4]
These matches were played on 27, 28 and 29 August 2021.[5]
| 1. | JS Chapelloise (11) | 0–4 | Montpon-Ménesplet FC (8) | |
| 2. | ES Ligniac (11) | 0–3 | Limoges Landouge (7) | |
| 3. | FC Smarves Iteuil (9) | 3–0 | Buslaurs Thireuil (10) | |
| 4. | FC Loudun (10) | 2–3 | Espérance Availles-en-Châtellerault (10) | |
| 5. | Antran SL (8) | 1–1 | FC Vrines (9) | |
| 6. | Gati-Foot (10) | 5–0 | US Jaunay-Clan (10) | |
| 7. | CO Cerizay (8) | 1–1 | US Envigne (9) | |
| 8. | SL Cenon-sur-Vienne (11) | 0–3 | ES Louzy (10) | |
| 9. | AS Périgné (12) | 1–0 | US Aulnay (9) | |
| 10. | La Jarrie FC (10) | 2–0 | CS Beauvoir-sur-Niort (10) | |
| 11. | Saint-Porchaire-Corme Royal FC (10) | 0–3 | Rochefort FC (7) | |
| 12. | FC Nord 17 (8) | 4–1 | US Frontenay-Saint-Symphorien (9) | |
| 13. | US Marennaise (8) | 3–0 | AS Aigre (9) | |
| 14. | UAS Verdille (9) | 1–1 | Avenir Matha (7) | |
| 15. | Val de Boutonne Foot 79 (10) | 2–4 | Oléron FC (8) | |
| 16. | AS Maritime (8) | 0–2 | EFC DB2S (8) | |
| 17. | US Pont l'Abbé d'Arnoult (11) | 0–6 | ES Celles-Verrines (8) | |
| 18. | Canton Aunis FC (10) | 3–3 | CS Venise Verte (11) | |
| 19. | FC Saint-Rogatien (10) | 4–1 | FC Saint-Fraigne (11) | |
| 20. | FC Saint-Amant-de-Boixe (11) | 0–5 | US Pays Maixentais (8) | |
| 21. | AS Cabariot (8) | 0–0 | AS Aiffres (7) | |
| 22. | US La Crèche (10) | 3–1 | AS Saint-Christophe 17 (10) | |
| 23. | AS Valdivienne (10) | 2–1 | FC Rouillé (9) | |
| 24. | Avenir Nord Foot 87 (10) | 5–2 | US Vivonne (11) | |
| 25. | FC Confolentais (9) | 0–0 | US Chasseneuil (10) | |
| 26. | US Anais (11) | 1–7 | Tardoire FC La Roche/Rivières (8) | |
| 27. | US Le Dorat (10) | 0–6 | FC Usson-Isle (9) | |
| 28. | Entente Saint-Maurice-Gençay (14) | 3–4 | FC Fleuré (9) | |
| 29. | Entente Nanteuil-Verteuil (12) | 0–1 | SC Verrières (9) | |
| 30. | AS Civaux (11) | 1–2 | ASFC Vindelle (8) | |
| 31. | AS Saint-Yrieix (9) | 3–1 | ES Château-Larcher (9) | |
| 32. | Fontafie FC (11) | 8–1 | Espérance Saint-Bonnet-de-Bellac (11) | |
| 33. | ES Montignac 16 (11) | 0–2 | OC Sommières Saint-Romain (11) | |
| 34. | FC Chaillac Saillat (12) | 0–2 | Rochechouart OC (11) | |
| 35. | ASPTT Limoges (11) | 0–1 | AS Lussac-les-Églises (11) | |
| 36. | US Oradour-sur-Glane (11) | 1–4 | FC des 2 Vallées (9) | |
| 37. | ES Ussel (9) | 2–2 | CS Boussac (8) | |
| 38. | US Donzenac (7) | 1–1 | FC Sarlat-Marcillac (8) | |
| 39. | FC Pays Arédien (11) | 1–1 | CA Chamboulive (9) | |
| 40. | CS Allassac (9) | 1–4 | FC Argentat (8) | |
| 41. | ES Nonards (8) | 3–1 | Entente Perpezac Sadroc (9) | |
| 42. | USA Saint-Aigulin (10) | 2–4 | AS Puymoyen (8) | |
| 43. | ES Mornac (10) | 6–3 | JS Abzac (11) | |
| 44. | AJ Montmoreau (10) | 3–1 | AS Neuvic-Saint-Léon (10) | |
| 45. | JS Basseau Angoulême (9) | 3–6 | FC Pays de Mareuil (8) | |
| 46. | AS Soyaux (8) | 2–3 | US Chancelade/Marsac (9) | |
| 47. | Union Saint-Médard Petit-Palais (10) | 4–0 | Tour Sportive et Merles Blancs 88 (10) | |
| 48. | Périgueux Foot (10) | 4–3 | US Artiguaise (11) | |
| 49. | USA Montbronn (10) | 2–0 | US Annesse-et-Beaulieu (10) | |
| 50. | AS Bel-Air (11) | 3–1 | JS Garat-Sers-Vouzan (11) | |
| 51. | AS Chazelles (11) | 0–0 | OFC Ruelle (8) | |
| 52. | SL Châteaubernard (11) | 0–3 | SC Cadaujac (8) | |
| 53. | SJ Artigues (12) | 0–3 | Alliance Foot 3B (8) | |
| 54. | SC Mouthiers (9) | 7–1 | US Nord Gironde (10) | |
| 55. | US Châteauneuf 16 (10) | 0–3 | AS Merpins (7) | |
| 56. | ES Thénacaise (11) | 0–3 | RC Bordeaux Métropole (8) | |
| 57. | US La Gémoze (10) | 1–1 | USJ Saint-Augustin Club Pyrénées Aquitaine (10) | |
| 58. | ALFC Fontcouverte (10) | 3–3 | FC Côteaux Bordelais (8) | |
| 59. | CS Saint-Michel-sur-Charente (9) | 1–0 | US Saujon (9) | |
| 60. | FC Casteljaloux (10) | 3–0 | CA Castets-en-Dorthe (11) | |
| 61. | ASSA Pays du Dropt (8) | 4–0 | AS Miramont-Lavergne (9) | |
| 62. | FC Nérac en Albret (9) | 1–2 | Entente Boé Bon-Encontre (7) | |
| 63. | AS Pays de Montaigne et Gurçon (9) | 2–2 | VS Caudrot (9) | |
| 64. | Football Sud Bastide (10) | 3–1 | FC Vallée de la Dordogne (11) | |
| 65. | AS Côteaux Dordogne (10) | 1–7 | Confluent Football 47 (7) | |
| 66. | FC Espagnol Pau (11) | 0–3 | Labenne OSC (8) | |
| 67. | FC Lacajunte-Tursan (9) | 2–2 | FC Gan (10) | |
| 68. | Bleuets Pau (8) | 3–4 | FC Saint-Vincent-de-Paul (9) | |
| 69. | SC Arthez Lacq Audejos (8) | 3–0 | AS Mourenx-Bourg (9) | |
| 70. | US Armagnac (11) | 2–4 | FC Parentis (9) | |
| 71. | FC La Ribère (8) | 2–1 | US Garein (9) | |
| 72. | ES Montoise (8) | 1–4 | AS Facture-Biganos Boïens (8) | |
| 73. | Violette Aturine (8) | 2–0 | AS des Églantines de Hendaye (9) | |
| 74. | Biscarrosse OFC (8) | 0–2 | FC Belin-Béliet (8) | |
| 75. | FC Oloronais (9) | 2–0 | US Saint-Palais Amikuze (9) | |
| 76. | Fraternelle Landiras (10) | 0–5 | FC Saint-Martin-de-Seignanx (8) | |
| 77. | Patronage Bazadais (8) | 1–2 | FC Luy de Béarn (8) | |
| 78. | FC Pays Argentonnais (9) | 6–0 | Union Cernay-Saint-Genest (10) | |
| 79. | ES Saint-Amand-sur-Sèvre (11) | 3–1 | Entente Voulmentin-Saint-Aubin-du-Plain-La Coudre (11) | |
| 80. | CL Noirlieu-Chambroutet Bressuire (11) | 0–3 | US Thuré-Besse (10) | |
| 81. | SC L'Absie-Largeasse/Moutiers-sous-Chantmerle (11) | 1–4 | ES Aubinrorthais (8) | |
| 82. | SC Vouzailles (13) | 1–2 | US Leignes-sur-Fontaine (10) | |
| 83. | FC Vouneuil-sous-Biard-Béruges (10) | 2–1 | Amicale Coussay-les-Bois (11) | |
| 84. | FC ASM (11) | 0–3 | ES Oyré-Dangé (9) | |
| 85. | US Cissé (12) | 0–10 | ES Nouaillé (8) | |
| 86. | Bel-Air Rocs OC Poitiers (11) | 0–3 | US Vicq-sur-Gartempe (8) | |
| 87. | FC Plaine Gâtine (12) | 2–3 | FC Comores Bressuire (11) | |
| 88. | US Vergentonnaise (12) | 0–7 | Inter Bocage FC (9) | |
| 89. | US Champdeniers-Pamplie (11) | 3–2 | FC Clazay Bocage (11) | |
| 90. | Croutelle FC (12) | 1–1 | US Vouillé (11) | |
| 91. | ASC Portugais Parthenay et de Gâtine (11) | 0–10 | FC Jardres (12) | |
| 92. | FC Chiché (11) | 3–2 | ACS Mahorais 79 (10) | |
| 93. | ASA Couronneries (11) | 0–0 | AS Portugais Châtellerault (8) | |
| 94. | ES Pays Thénezéen (10) | 5–0 | US Brion 79 (11) | |
| 95. | AS Saint-Christophe 86 (12) | 0–3 | JS Nieuil l'Espoir (8) | |
| 96. | ES Boismé Clessé (12) | 1–1 | FC Châtillon (12) | |
| 97. | AS Sèvres-Anxaumont (10) | 0–3 | FC Saint-Jean-Missé (11) | |
| 98. | FC Sud Gâtine (10) | 4–0 | AAS Saint-Julien-l'Ars (10) | |
| 99. | AS Poitiers Gibauderie Mahorais (11) | 7–1 | SA Mauzé-Rigné (11) | |
| 100. | AS Saint-Léger Montbrillais (11) | 1–3 | EF Le Tallud (7) | |
| 101. | AS Saint-Loup Louin (13) | 1–4 | AS Portugais Cerizay (10) | |
| 102. | FC Chanteloup-Courlay-Chapelle (10) | 4–1 | Boivre SC (10) | |
| 103. | ES Fayenoirterre (11) | 1–1 | US Mirebeau (11) | |
| 104. | CEP Poitiers (11) | 1–2 | Avenir Autize (11) | |
| 105. | FC Montamisé (10) | 3–1 | US Saint-Varent Pierregeay (8) | |
| 106. | Pleumartin-La Roche-Posay FC (12) | 0–5 | ES Trois Cités Poitiers (9) | |
| 107. | AS Colombiers (13) | 2–2 | US Vasléenne (9) | |
| 108. | ES Saint-Cerbouillé (8) | 1–2 | FC Fontaine-le-Comte (8) | |
| 109. | US Avanton (10) | 2–1 | ES Beaulieu-Breuil (10) | |
| 110. | FC Pays de l'Ouin (8) | 4–1 | Ozon FC (9) | |
| 111. | Biard FC (11) | 2–2 | Chasseneuil-Saint-Georges FC (9) | |
| 112. | AS Coulonges-Thouarsais (11) | 2–5 | FC Airvo Saint-Jouin (9) | |
| 113. | US Vrère-Saint-Léger-de-Montbrun (10) | 0–3 | US Saint-Sauveur (7) | |
| 114. | AS Sainte-Ouenne (13) | 1–1 | Espérance Terves (8) | |
| 115. | CA Saint-Aubin-le-Cloud (9) | 4–1 | US Nord Vienne (10) | |
| 116. | ES La Pallu (11) | 1–2 | ES Saint-Benoit (8) | |
| 117. | ASPTT Bessines (12) | 2–5 | ES Ardin (9) | |
| 118. | US Mauzé-sur-le-Mignon (10) | 4–0 | JS Angoulins (11) | |
| 119. | US Lezay (10) | 3–1 | AS Vérines (11) | |
| 120. | AS Andilly (10) | 1–1 | ES Brûlain (10) | |
| 121. | Amicale Saint-Martin (12) | 0–0 | FC Rouillac (11) | |
| 122. | FC de la Soie (11) | 1–5 | AS Pays Mellois (8) | |
| 123. | Espoir Haut Vals de Saintonge (11) | 1–9 | Aunis AFC (9) | |
| 124. | ES Clussais (11) | 2–2 | FC Canton de Courçon (11) | |
| 125. | ES Tonnacquoise-Lussantaise (10) | 3–3 | DR Boucholeurs-Châtelaillon-Yves (10) | |
| 126. | AR Cherveux (12) | 2–0 | FC Haut Val de Sèvre (10) | |
| 127. | AS Sainte-Néomays Romans (12) | 0–1 | Capaunis ASPTT FC (8) | |
| 128. | AS Argenteuil Angerien Poursay-Garnaud (10) | 0–3 | AAAM Laleu-La Pallice (8) | |
| 129. | ASS Portugais La Rochelle (11) | 3–0 | ES Saint-Just-Luzac (9) | |
| 130. | ACS La Rochelle (10) | 2–1 | AS Saint-Martin-lès-Melle (11) | |
| 131. | Avenir 79 FC (9) | 3–0 | Entente Soubise Port-des-Barques (10) | |
| 132. | ES Muron Genouillé (12) | 0–2 | US Aigrefeuille (9) | |
| 133. | AS Exoudun (12) | 2–3 | Breuil-Magné FC (11) | |
| 134. | US Prahecq (12) | 0–6 | AS Réthaise (7) | |
| 135. | Stade Boisseuillais (12) | 2–4 | ESAB 96 FC (10) | |
| 136. | ES Mougon (11) | 0–3 | Stade Vouillé (8) | |
| 137. | AS Augé/Azay-le-Brûlé (11) | 0–0 | Aviron Boutonnais (9) | |
| 138. | US Pexinoise Niort (12) | 1–7 | FC Essouvert Loulay (10) | |
| 139. | SEPC Exireuil (11) | 0–4 | FC Boutonnais (10) | |
| 140. | AS Blanzay (13) | 0–4 | CS Saint-Angeau (10) | |
| 141. | Coqs Rouges Mansle (10) | 1–7 | AS Brie (9) | |
| 142. | SC Champagné-Saint-Hilaire (12) | 2–10 | ES Brion-Saint-Secondin (10) | |
| 143. | US Lessac (10) | 2–3 | ES Champniers (8) | |
| 144. | US Availles-Limouzine (14) | 2–8 | Entente Foot 16 (11) | |
| 145. | Taizé-Aizie Les Adjots (12) | 0–4 | Avenir Bellac-Berneuil-Saint-Junien-les-Combes (8) | |
| 146. | AS Vars (12) | 1–7 | US Leigné-sur-Usseau (11) | |
| 147. | US Abzac (11) | 3–1 | AS Payroux Charroux Mauprévoir (11) | |
| 148. | CS Chatain (12) | 0–2 | US Mélusine (9) | |
| 149. | FC Vallée du Salleron (13) | 1–3 | Valence-en-Poitou OC (10) | |
| 150. | SC Agris (13) | 2–1 | ES Nouic Mézières (12) | |
| 151. | AS Saint-Saviol (12) | 1–11 | ACG Foot Sud 86 (10) | |
| 152. | AS La Jonchère-Saint-Maurice (11) | 0–12 | SA Le Palais-sur-Vienne (7) | |
| 153. | US Saint-Fiel (9) | 1–2 | AS Châteauneuf-Neuvic (8) | |
| 154. | Boisseuil FC (10) | 1–0 | US Nantiat (9) | |
| 155. | ES Dun-Naillat (10) | 0–2 | Limoges Football (9) | |
| 156. | USS Mérinchal (9) | 4–0 | US Vallière (10) | |
| 157. | SC Verneuil-sur-Vienne (8) | 3–0 | US Felletin (8) | |
| 158. | Diables Bleus Bersac (11) | 2–2 | US Saint-Vaury (9) | |
| 159. | FC Saint-Priest-sous-Aixe (10) | 1–1 | US Saint-Léonard-de-Noblat (8) | |
| 160. | AS Aiguille Bosmie Charroux (11) | 3–3 | Football Cognacois Cyrien Laurentais (11) | |
| 161. | AS Saint-Just-le-Martel (10) | 3–0 | CA Égletons (9) | |
| 162. | AC Kurdes Limoges (10) | 2–0 | AS Limoges Roussillon (8) | |
| 163. | AS Marcillac Clergoux (11) | 1–1 | AS Saint-Louis Val de l'Aurence (10) | |
| 164. | AS Eymoutiers (9) | 0–1 | AS Saint-Junien (8) | |
| 165. | USC Bourganeuf (9) | 2–1 | CA Saint-Victurnien (10) | |
| 166. | AS Reterre Fontanières (10) | 0–10 | EF Aubussonnais (8) | |
| 167. | Vigenal FC Limoges (8) | 3–1 | JS Chambon-sur-Voueize (9) | |
| 168. | ES Bénévent-Marsac (9) | 3–1 | RFC Sainte-Feyre (9) | |
| 169. | Espoirs La Geneytouse (9) | 3–5 | FC Saint-Brice-sur-Vienne (10) | |
| 170. | SC Séreilhac (11) | 1–0 | SC Sardent (9) | |
| 171. | CA Peyrat-la-Nonière (9) | 6–1 | US Beaune-les-Mines (9) | |
| 172. | ES Evaux-Budelière (10) | 4–6 | US Veyrac (10) | |
| 173. | FC Canton d'Oradour-sur-Vayres (10) | 1–2 | US Bessines-Morterolles (8) | |
| 174. | AS Saint-Sulpice-le-Guérétois (8) | 1–0 | US Auzances (9) | |
| 175. | AS Ambazac (9) | 0–1 | CA Meymac (8) | |
| 176. | FC Bassimilhacois (9) | 1–1 | US Pays de Fénelon (10) | |
| 177. | AS Saint-Viance (11) | 1–2 | FC Cornilois-Fortunadais (9) | |
| 178. | USA Terrasson (11) | 1–5 | Auvézère Mayne FC (9) | |
| 179. | Amicale Saint-Hilaire Venersal (10) | 2–2 | FC Thenon-Limeyrat-Fossemagne (7) | |
| 180. | FC Spartak Carsac (12) | 0–3 | ES Portugais Brive (10) | |
| 181. | ASPO Brive (8) | 5–2 | AS Beynat (8) | |
| 182. | FC Saint-Jal (11) | 0–6 | La Thibérienne (8) | |
| 183. | Olympique Larche Lafeuillade (9) | 1–1 | SS Sainte-Féréole (8) | |
| 184. | Occitane FC (9) | 2–2 | Varetz AC (9) | |
| 185. | US La Roche l'Abeille (9) | 2–0 | Entente SR3V (9) | |
| 186. | AS Nexon (9) | 4–1 | Condat FC (10) | |
| 187. | CA Brignac (11) | 1–1 | Foot Sud 87 (9) | |
| 188. | Cosnac FC (10) | 2–2 | FREP Saint-Germain (9) | |
| 189. | APCS Mahorais Brive (11) | 2–0 | Entente des Barrages de la Xaintrie (9) | |
| 190. | FC Objat (10) | 3–2 | US Saint-Clementoise (9) | |
| 191. | US Lanteuil (9) | 4–1 | ES Ussac (9) | |
| 192. | Campagnac Daglan Saint-Laurent Foot (12) | 0–3 | AS Jugeals-Noailles (9) | |
| 193. | AS Collonges Chauffour (11) | 0–12 | ASV Malemort (9) | |
| 194. | FC Cublac (12) | 3–0 | AS Seilhac (10) | |
| 195. | AC Gond-Pontouvre (12) | 1–2 | FC Charentais L'Isle-d'Espagnac (10) | |
| 196. | Les Aiglons Razacois (10) | 0–4 | SA Sanilhacois (9) | |
| 197. | Entente Grignols Villamblard (11) | 0–6 | AS Nontron-Saint-Pardoux (7) | |
| 198. | FC Atur (11) | 0–3 | AC Sud Saintonge (9) | |
| 199. | US Coutras (11) | 1–1 | CA Ribéracois (8) | |
| 200. | Saint-Seurin JC (12) | 3–0 | Gué-de-Sénac FC (10) | |
| 201. | FC Saint-Antoine (12) | 1–3 | Entente Saint-Séverin/Palluaud (10) | |
| 202. | Étoile La Roche-Chalais (11) | 0–2 | CS Leroy Angoulême (7) | |
| 203. | La Patriote Agonac (10) | 0–8 | Limens JSA (8) | |
| 204. | US Marsaneix Manoire (11) | 3–1 | GSF Portugais Angoulême (9) | |
| 205. | AS Laurentine (11) | 3–6 | JS Saint-Christophe-de-Double (11) | |
| 206. | AS Coursac (11) | 1–3 | CO Coulouniex-Chamiers (9) | |
| 207. | US Tocane-Saint-Apre (10) | 1–0 | AS Saint-Germain-Chantérac (11) | |
| 208. | US Ma Campagne Angoulême (10) | 6–1 | US Saint-Denis-de-Pile (10) | |
| 209. | AG Vendays-Montalivet (11) | 2–1 | AS Chambéry (11) | |
| 210. | USC Léognan (10) | 1–2 | Saint-Palais SF (8) | |
| 211. | FC Roullet-Saint-Estèphe (8) | 0–2 | FC Pessac Alouette (7) | |
| 212. | RC Chambéry (10) | 0–0 | FC Sévigné Jonzac-Saint-Germain (8) | |
| 213. | AS Saint-Aubin-de-Médoc (10) | 1–5 | ES Eysinaise (9) | |
| 214. | FC Pierroton Cestas Toctoucau (11) | 3–4 | Parempuyre FC (11) | |
| 215. | AGJA Caudéran (10) | 1–1 | FC Cœur Médoc Atlantique (7) | |
| 216. | JS Bersonnaise (12) | 0–7 | US Pons (10) | |
| 217. | Stade Blayais (11) | 4–0 | ES Fronsadaise (9) | |
| 218. | CA Carignanais (11) | 1–0 | FCA Moron (8) | |
| 219. | FC Cubzac-les-Ponts (11) | 3–6 | FC Seudre Ocean (10) | |
| 220. | AS Montferrand (10) | 1–5 | SJ Macaudaise (9) | |
| 221. | Bouliacaise FC (11) | 3–3 | FC Portes d'Océan 17 (9) | |
| 222. | SC Bastidienne (9) | 1–1 | AL Saint-Brice (10) | |
| 223. | JS Semussac (10) | 7–0 | US Cercoux Clottaise (11) | |
| 224. | ES Bruges (10) | 3–0 | Nersac FC (10) | |
| 225. | ES Linars (9) | 0–0 | Montesquieu FC (8) | |
| 226. | Stade Pessacais UC (10) | 1–2 | FC Arsac-Pian Médoc (8) | |
| 227. | APIS en Aquitaine (12) | 2–6 | FC Gradignan (10) | |
| 228. | FC Sud 17 (9) | 3–0 | CM Floirac (10) | |
| 229. | Athletic 89 FC (10) | 1–2 | CMO Bassens (9) | |
| 230. | Union Pauillac Saint-Laurent (9) | 1–1 | FC Saint André-de-Cubzac (7) | |
| 231. | US Ludon (11) | 0–7 | FC Martignas-Illac (8) | |
| 232. | Saint-Seurin Saint-Estèphe FC (11) | 3–2 | FC Ambès (11) | |
| 233. | SC Bédenac Laruscade (12) | 0–4 | CO La Couronne (8) | |
| 234. | FC Cubnezais (11) | 2–4 | FC Loubesien (9) | |
| 235. | ES Fléac (11) | 0–7 | AS Le Taillan (8) | |
| 236. | CS Portugais Villenave-d'Ornon (9) | 5–0 | FC Médoc Océan (8) | |
| 237. | AS Mosnac (12) | 0–7 | ES Ambares (8) | |
| 238. | US Cenon Rive Droite (8) | 4–0 | Sporting Chantecler Bordeaux Nord le Lac (8) | |
| 239. | Union Saint-Jean (11) | 4–1 | AS Avensan-Moulis-Listrac (11) | |
| 240. | ES Canéjan (10) | 1–2 | Bordeaux Étudiants CF (10) | |
| 241. | Targon-Soulignac FC (9) | 2–0 | UFC Saint-Colomb-de-Lauzun (9) | |
| 242. | AS Laugnac (11) | 1–2 | FC Gironde La Réole (9) | |
| 243. | ES Mazères-Roaillan (11) | 0–0 | US Allemans-du-Dropt (11) | |
| 244. | FC Belvès (11) | 0–4 | Langon FC (7) | |
| 245. | AS Morizes (11) | 0–5 | AS Castillonnès Cahuzac Lalande (8) | |
| 246. | FC Côteaux Pécharmant (9) | 1–0 | FC Limeuil (9) | |
| 247. | US Lamothe-Mongauzy (10) | 1–5 | FC Côteaux Libournais (8) | |
| 248. | Roquentin OC (11) | 0–3 | Mas AC (9) | |
| 249. | US Villeréal (12) | 2–3 | SC Astaffortais (11) | |
| 250. | FCC Créonnais (10) | 2–2 | AS Gensac-Montcaret (8) | |
| 251. | FCO Eymetoise (11) | 0–3 | US Bazeillaise (11) | |
| 252. | AS Beautiran FC (12) | 1–1 | AS Sauveterrienne (11) | |
| 253. | Athlético Vernois (10) | 1–1 | Prigonrieux FC (7) | |
| 254. | US Virazeil-Puymiclan (9) | 4–1 | FC Pays Beaumontois (9) | |
| 255. | FC Faux (9) | 6–1 | FC Penne Saint-Sylvestre (10) | |
| 256. | Saint-Sulpice Jeunesse (11) | 0–7 | FC Porte d'Aquitaine 47 (9) | |
| 257. | Bleuets Macariens (11) | 1–8 | AS Marcellus-Cocumont (9) | |
| 258. | US Port Sainte-Marie Feugarolles (10) | 5–2 | US Gontaud (9) | |
| 259. | SJ Bergerac (11) | 2–1 | Pays de l'Eyraud (10) | |
| 260. | AF Casseneuil-Pailloles-Lédat (8) | 2–3 | FC Périgord Centre (8) | |
| 261. | FC Pineuilh (11) | 1–8 | FC Pays Aurossais (8) | |
| 262. | FC Clairacais (11) | 0–9 | SC Monségur (11) | |
| 263. | FLR Le Monteil (11) | 5–1 | Les Rouges de Saint-Jean Libourne (11) | |
| 264. | US Farguais (11) | 0–2 | SU Agen (8) | |
| 265. | AS Tarnos (8) | 2–2 | ES Nay-Vath-Vielha (9) | |
| 266. | CA Sallois (9) | 3–0 | AS Cazères (10) | |
| 267. | RC Dax (11) | 1–1 | FC Born (9) | |
| 268. | FC Artiguelouve-Arbus-Aubertin (10) | 1–1 | Union Jurançonnaise (8) | |
| 269. | Papillons de Pontacq (10) | 0–1 | ES Pyrénéenne (10) | |
| 270. | US Illats (10) | 1–5 | AS Pontonx (8) | |
| 271. | Avenir Mourenxois (10) | 6–0 | USV Gelosienne (8) | |
| 272. | Baiona FC (10) | 2–1 | FA Bourbaki Pau (9) | |
| 273. | Étoile Béarnaise FC (10) | 2–3 | Carresse Salies FC (10) | |
| 274. | Peyrehorade SF (10) | 1–4 | CS Lantonnais (8) | |
| 275. | SC Saint-Symphorien (10) | 1–4 | Andernos Sport FC (7) | |
| 276. | Sud Gironde FC (10) | 1–0 | FC Barpais (9) | |
| 277. | JS Laluque-Rion (9) | 0–2 | ES Meillon-Assat-Narcastet (8) | |
| 278. | Ardanavy FC (11) | 2–2 | Chalosse FC (10) | |
| 279. | Cazaux Olympique (9) | 5–2 | SA Saint-Séverin (8) | |
| 280. | US Castétis-Gouze (9) | 5–3 | Marensin FC (10) | |
| 281. | FC Hagetmautien (8) | 2–4 | JA Biarritz (7) | |
| 282. | FC Vallée de l'Ousse (9) | 1–6 | Association Saint-Laurent Billère (9) | |
| 283. | Monein FC (11) | 1–3 | FC Roquefort Saint-Justin (9) | |
| 284. | Jeanne d'Arc Le Béarn Pau (10) | 0–1 | Pardies Olympique (8) | |
| 285. | Saint-Perdon Sports (9) | 0–3 | Stade Ygossais (7) | |
| 286. | FC des Enclaves et du Plateau (10) | 1–1 | AS Artix (8) | |
| 287. | ES Latrille-Saint-Agnet (10) | 1–1 | FC Morcenx-Arengosse (8) | |
| 288. | AS Villandraut-Préchac (11) | 1–5 | ES Audenge (7) | |
| 289. | Kanboko Izarra (11) | 1–3 | FA Morlaàs Est Béarn (7) | |
| 290. | AS Lous Marous/FC Saint-Geours (10) | 3–3 | Espérance Oeyreluy (11) | |
| 291. | US Marsan (9) | 0–8 | Hasparren FC (8) | |
| 292. | SC Cabanac Villagrain (12) | 1–4 | JS Teichoise (9) | |
| 293. | SC Taron Sévignacq (11) | 3–1 | FC Lons (8) | |
| 294. | ES Bournos-Doumy-Garlède (10) | 0–3 | AS Mazères-Uzos-Rontignan (8) | |
| 295. | SA Mauléonais (8) | 2–2 | Les Labourdins d'Ustaritz (8) |
These matches were played on 3, 4 and 5 September 2021.[6]
| 1. | Antran SL (8) | 1–3 | ES Beaumont-Saint-Cyr (7) | |
| 2. | ES Eysinaise (9) | 5–1 | AJ Montmoreau (10) | |
| 3. | FC Talence (7) | 1–3 | FC des Portes de l'Entre-Deux-Mers (6) | |
| 4. | La Thibérienne (8) | 1–2 | CO Coulouniex-Chamiers (9) | |
| 5. | FC Objat (10) | 0–6 | Périgueux Foot (10) | |
| 6. | FC Gradignan (10) | 0–1 | FC des Graves (7) | |
| 7. | US La Crèche (10) | 0–3 | Étoile Maritime FC (7) | |
| 8. | Limoges Football (9) | 2–1 | SA Le Palais-sur-Vienne (7) | |
| 9. | CS Boussac (8) | 3–0 | CA Peyrat-la-Nonière (9) | |
| 10. | AS Facture-Biganos Boïens (8) | 2–2 | St Paul Sport (6) | |
| 11. | FA Morlaàs Est Béarn (7) | 1–2 | JA Biarritz (7) | |
| 12. | ES Nouaillé (8) | 1–6 | ES Buxerolles (6) | |
| 13. | US Vasléenne (9) | 0–3 | RC Parthenay Viennay (7) | |
| 14. | ES Oyré-Dangé (9) | 2–0 | US Leignes-sur-Fontaine (10) | |
| 15. | ES Saint-Benoit (8) | 0–1 | FC Smarves Iteuil (9) | |
| 16. | US Pays Maixentais (8) | 3–3 | US Vicq-sur-Gartempe (8) | |
| 17. | SC Verrières (9) | 3–0 | US Mélusine (9) | |
| 18. | ES Ardin (9) | 0–0 | US Avanton (10) | |
| 19. | FC Airvo Saint-Jouin (9) | 2–2 | FC Nueillaubiers (6) | |
| 20. | AS Valdivienne (10) | 1–1 | CA Saint-Savin-Saint-Germain (7) | |
| 21. | Gati-Foot (10) | 5–1 | ES Pays Thénezéen (10) | |
| 22. | ES Champniers (8) | 0–3 | FC Charente Limousine (7) | |
| 23. | Tardoire FC La Roche/Rivières (8) | 1–1 | SC Verneuil-sur-Vienne (8) | |
| 24. | AS Brie (9) | 2–2 | AS Saint-Junien (8) | |
| 25. | Avenir Bellac-Berneuil-Saint-Junien-les-Combes (8) | 0–2 | UES Montmorillon (6) | |
| 26. | FC Charentais L'Isle-d'Espagnac (10) | 0–7 | US Veyrac (10) | |
| 27. | ACG Foot Sud 86 (10) | 3–3 | FC Boutonnais (10) | |
| 28. | Avenir Nord Foot 87 (10) | 0–7 | Stade Ruffec (7) | |
| 29. | US Chasseneuil (10) | 5–1 | FC Saint-Brice-sur-Vienne (10) | |
| 30. | AS Bel-Air (11) | 2–4 | AS Puymoyen (8) | |
| 31. | AAAM Laleu-La Pallice (8) | 0–0 | Avenir 79 FC (9) | |
| 32. | Aunis AFC (9) | 1–1 | FC Périgny (7) | |
| 33. | Rochefort FC (7) | 2–2 | AS Cozes (7) | |
| 34. | AS Périgné (12) | 2–0 | ESAB 96 FC (10) | |
| 35. | ES Celles-Verrines (8) | 1–3 | SC Saint-Jean-d'Angély (6) | |
| 36. | EFC DB2S (8) | 0–4 | Royan Vaux AFC (6) | |
| 37. | FC Saint-Rogatien (10) | 0–1 | ASFC Vindelle (8) | |
| 38. | ALFC Fontcouverte (10) | 1–1 | ES Saintes (7) | |
| 39. | La Jarrie FC (10) | 1–5 | FC Chauray (6) | |
| 40. | FC Rouillac (11) | 1–4 | CS Saint-Michel-sur-Charente (9) | |
| 41. | US Bessines-Morterolles (8) | 1–2 | ES Bénévent-Marsac (9) | |
| 42. | AS Gouzon (7) | 5–0 | Vigenal FC Limoges (8) | |
| 43. | FC Argentat (8) | 1–0 | USS Mérinchal (9) | |
| 44. | AS Châteauneuf-Neuvic (8) | 1–1 | JS Lafarge Limoges (7) | |
| 45. | CA Meymac (8) | 0–2 | JA Isle (6) | |
| 46. | ES Nonards (8) | 0–0 | ES Guérétoise (6) | |
| 47. | FC Périgord Centre (8) | 4–1 | Occitane FC (9) | |
| 48. | USA Montbronn (10) | 5–2 | US Marsaneix Manoire (11) | |
| 49. | US Donzenac (7) | 2–2 | AS Saint-Pantaleon (6) | |
| 50. | Auvézère Mayne FC (9) | 0–3 | ASV Malemort (9) | |
| 51. | FC Cœur Médoc Atlantique (7) | 3–0 | US Cenon Rive Droite (8) | |
| 52. | FC Arsac-Pian Médoc (8) | 1–4 | FCE Mérignac Arlac (6) | |
| 53. | FC Martignas-Illac (8) | 0–0 | JS Sireuil (7) | |
| 54. | Entente Saint-Séverin/Palluaud (10) | 2–4 | Montpon-Ménesplet FC (8) | |
| 55. | SC Mouthiers (9) | 1–1 | FC Saint André-de-Cubzac (7) | |
| 56. | FC Grand Saint-Emilionnais (7) | 2–1 | CA Sainte-Hélène (7) | |
| 57. | FC Sévigné Jonzac-Saint-Germain (8) | 3–1 | CA Ribéracois (8) | |
| 58. | US La Gémoze (10) | 1–5 | ES Bruges (10) | |
| 59. | Union Saint-Médard Petit-Palais (10) | 0–2 | US Mussidan-Saint Medard (6) | |
| 60. | US Pons (10) | 1–1 | FC Saint-Médard-en-Jalles (6) | |
| 61. | SU Agen (8) | 0–0 | FC Vallée du Lot (7) | |
| 62. | AS Marcellus-Cocumont (9) | 0–6 | SA Mérignac (6) | |
| 63. | Entente Boé Bon-Encontre (7) | 3–3 | Jeunesse Villenave (6) | |
| 64. | Labenne OSC (8) | 1–1 | Violette Aturine (8) | |
| 65. | AS Pontonx (8) | 1–2 | AS Mazères-Uzos-Rontignan (8) | |
| 66. | FC Roquefort Saint-Justin (9) | 1–5 | SA Mauléonais (8) | |
| 67. | FC Oloronais (9) | 0–1 | SC Saint-Pierre-du-Mont (7) | |
| 68. | FC Casteljaloux (10) | 0–2 | Croisés Saint-André Bayonne (7) | |
| 69. | Stade Ygossais (7) | 3–1 | Élan Béarnaise Orthez (6) | |
| 70. | FC Saint-Vincent-de-Paul (9) | 1–0 | Avenir Mourenxois (10) | |
| 71. | FC Luy de Béarn (8) | 2–1 | Association Saint-Laurent Billère (9) | |
| 72. | Espérance Availles-en-Châtellerault (10) | 2–2 | FC Vouneuil-sous-Biard-Béruges (10) | |
| 73. | FC Saint-Jean-Missé (11) | 4–0 | FC Chanteloup-Courlay-Chapelle (10) | |
| 74. | FC Sud Gâtine (10) | 0–2 | La Ligugéenne Football (7) | |
| 75. | FC Fontaine-le-Comte (8) | 4–0 | AS Portugais Châtellerault (8) | |
| 76. | US Vouillé (11) | 3–5 | Espérance Terves (8) | |
| 77. | ES Saint-Amand-sur-Sèvre (11) | 0–1 | CS Naintré (7) | |
| 78. | US Thuré-Besse (10) | 4–0 | FC Chiché (11) | |
| 79. | ES Boismé Clessé (12) | 0–5 | Thouars Foot 79 (6) | |
| 80. | ES Louzy (10) | 0–1 | EF Le Tallud (7) | |
| 81. | FC Jardres (12) | 0–3 | US Migné-Auxances (7) | |
| 82. | AS Portugais Cerizay (10) | 4–1 | ES Fayenoirterre (11) | |
| 83. | Avenir Autize (11) | 7–0 | US Champdeniers-Pamplie (11) | |
| 84. | FC Montamisé (10) | 1–3 | US Saint-Sauveur (7) | |
| 85. | ES Trois Cités Poitiers (9) | 2–0 | FC Pays de l'Ouin (8) | |
| 86. | Chasseneuil-Saint-Georges FC (9) | 2–3 | CO Cerizay (8) | |
| 87. | FC Fleuré (9) | 0–3 | AS Mignaloux-Beauvoir (7) | |
| 88. | AS Poitiers Gibauderie Mahorais (11) | 2–3 | JS Nieuil l'Espoir (8) | |
| 89. | Valence-en-Poitou OC (10) | 5–3 | Inter Bocage FC (9) | |
| 90. | US Leigné-sur-Usseau (11) | 1–11 | SA Moncoutant (7) | |
| 91. | ES Aubinrorthais (8) | 3–1 | CA Saint-Aubin-le-Cloud (9) | |
| 92. | FC Comores Bressuire (11) | 1–1 | FC Pays Argentonnais (9) | |
| 93. | CS Saint-Angeau (10) | 0–1 | ES Clussais (11) | |
| 94. | OC Sommières Saint-Romain (11) | 2–0 | FC des 2 Vallées (9) | |
| 95. | ES Brion-Saint-Secondin (10) | 2–1 | OFC Ruelle (8) | |
| 96. | SC Agris (13) | 0–2 | US Abzac (11) | |
| 97. | AS Lussac-les-Églises (11) | 2–4 | Fontafie FC (11) | |
| 98. | FC Usson-Isle (9) | 2–1 | ES Mornac (10) | |
| 99. | Rochechouart OC (11) | 1–3 | AS Aixoise (7) | |
| 100. | AS Pays Mellois (8) | 2–5 | FC Portes d'Océan 17 (9) | |
| 101. | Aviron Boutonnais (9) | 3–0 | ES Tonnacquoise-Lussantaise (10) | |
| 102. | JS Semussac (10) | 0–9 | ES La Rochelle (6) | |
| 103. | FC Essouvert Loulay (10) | 1–6 | US Marennaise (8) | |
| 104. | ASS Portugais La Rochelle (11) | 0–3 | Saint-Palais SF (8) | |
| 105. | FC Seudre Ocean (10) | 1–2 | AS Cabariot (8) | |
| 106. | Breuil-Magné FC (11) | 2–2 | OL Saint-Liguaire Niort (6) | |
| 107. | US Lezay (10) | 2–1 | Oléron FC (8) | |
| 108. | AR Cherveux (12) | 1–3 | CS Leroy Angoulême (7) | |
| 109. | Stade Vouillé (8) | 2–2 | ES Linars (9) | |
| 110. | Entente Foot 16 (11) | 0–6 | Capaunis ASPTT FC (8) | |
| 111. | CS Venise Verte (11) | 2–3 | UAS Verdille (9) | |
| 112. | ES Brûlain (10) | 2–1 | AS Échiré Saint-Gelais (6) | |
| 113. | US Aigrefeuille (9) | 0–1 | FC Nord 17 (8) | |
| 114. | US Mauzé-sur-le-Mignon (10) | 0–2 | AS Saint-Yrieix (9) | |
| 115. | Jarnac SF (7) | 1–2 | UA Niort Saint-Florent (7) | |
| 116. | ACS La Rochelle (10) | 1–1 | AS Réthaise (7) | |
| 117. | ES Beaubreuil (7) | 3–2 | USE Couzeix-Chaptelat (7) | |
| 118. | AS Saint-Sulpice-le-Guérétois (8) | 1–3 | AS Panazol (7) | |
| 119. | Boisseuil FC (10) | 3–0 | Diables Bleus Bersac (11) | |
| 120. | AC Kurdes Limoges (10) | 0–1 | EF Aubussonnais (8) | |
| 121. | Amicale Franco-Portugais Limoges (7) | 3–3 | Tulle Football Corrèze (7) | |
| 122. | AS Saint-Just-le-Martel (10) | 3–3 | ES Marchoise (7) | |
| 123. | Limoges Landouge (7) | 2–1 | CA Rilhac-Rancon (7) | |
| 124. | USC Bourganeuf (9) | 0–7 | CS Feytiat (6) | |
| 125. | CA Chamboulive (9) | 3–3 | US Saint-Léonard-de-Noblat (8) | |
| 126. | AS Marcillac Clergoux (11) | 2–4 | FC Cornilois-Fortunadais (9) | |
| 127. | US La Roche l'Abeille (9) | 0–13 | ESA Brive (6) | |
| 128. | FC Pays de Mareuil (8) | 5–3 | ES Portugais Brive (10) | |
| 129. | US Lanteuil (9) | 0–2 | ES Boulazac (6) | |
| 130. | AS Nexon (9) | 3–2 | ASPO Brive (8) | |
| 131. | AS Aiguille Bosmie Charroux (11) | 2–4 | SS Sainte-Féréole (8) | |
| 132. | Foot Sud 87 (9) | 0–1 | Athlético Vernois (10) | |
| 133. | FC Cublac (12) | 2–2 | FC Thenon-Limeyrat-Fossemagne (7) | |
| 134. | SA Sanilhacois (9) | 2–2 | Limens JSA (8) | |
| 135. | FC Bassimilhacois (9) | 7–0 | US Tocane-Saint-Apre (10) | |
| 136. | Cosnac FC (10) | 0–10 | AS Nontron-Saint-Pardoux (7) | |
| 137. | APCS Mahorais Brive (11) | 1–3 | US Chancelade/Marsac (9) | |
| 138. | SC Séreilhac (11) | 1–1 | AS Jugeals-Noailles (9) | |
| 139. | FC Côteaux Libournais (8) | 4–1 | AC Sud Saintonge (9) | |
| 140. | Parempuyre FC (11) | 1–2 | AS Le Taillan (8) | |
| 141. | Stade Blayais (11) | 4–2 | AS Pays de Montaigne et Gurçon (9) | |
| 142. | FC Sud 17 (9) | 1–0 | AS Merpins (7) | |
| 143. | ES Ambares (8) | 1–3 | US Lormont (6) | |
| 144. | AG Vendays-Montalivet (11) | 0–2 | FC Loubesien (9) | |
| 145. | CMO Bassens (9) | 1–3 | Alliance Foot 3B (8) | |
| 146. | Bordeaux Étudiants CF (10) | 3–2 | CS Portugais Villenave-d'Ornon (9) | |
| 147. | Union Saint-Jean (11) | 1–5 | FC Estuaire Haute Gironde (6) | |
| 148. | US Ma Campagne Angoulême (10) | 0–2 | FC Mascaret (6) | |
| 149. | CO La Couronne (8) | 1–1 | ES Blanquefort (6) | |
| 150. | RC Bordeaux Métropole (8) | 0–3 | US Bouscataise (7) | |
| 151. | Saint-Seurin Saint-Estèphe FC (11) | 0–3 | Coqs Rouges Bordeaux (7) | |
| 152. | SJ Macaudaise (9) | 3–0 | SC Bastidienne (9) | |
| 153. | FC Pessac Alouette (7) | 0–2 | FC Marmande 47 (6) | |
| 154. | Football Sud Bastide (10) | 1–8 | FC Pays Aurossais (8) | |
| 155. | JS Saint-Christophe-de-Double (11) | 0–4 | ASSA Pays du Dropt (8) | |
| 156. | CA Carignanais (11) | 2–1 | AS Castillonnès Cahuzac Lalande (8) | |
| 157. | FC Porte d'Aquitaine 47 (9) | 1–2 | Stade Saint-Médardais (7) | |
| 158. | SJ Bergerac (11) | 1–2 | US Port Sainte-Marie Feugarolles (10) | |
| 159. | US Bazeillaise (11) | 4–1 | FLR Le Monteil (11) | |
| 160. | US Allemans-du-Dropt (11) | 1–1 | FC Faux (9) | |
| 161. | SC Astaffortais (11) | 0–9 | Langon FC (7) | |
| 162. | AS Beautiran FC (12) | 0–1 | Targon-Soulignac FC (9) | |
| 163. | Mas AC (9) | 0–4 | CA Béglais (7) | |
| 164. | AS Gensac-Montcaret (8) | 0–1 | US Virazeil-Puymiclan (9) | |
| 165. | FC Côteaux Pécharmant (9) | 0–3 | La Brède FC (6) | |
| 166. | SC Cadaujac (8) | 0–2 | SAG Cestas (6) | |
| 167. | SC Monségur (11) | 0–5 | Confluent Football 47 (7) | |
| 168. | Saint-Seurin JC (12) | 0–4 | US La Catte (7) | |
| 169. | FC Gironde La Réole (9) | 0–7 | Union Saint-Bruno (7) | |
| 170. | Espérance Oeyreluy (11) | 2–4 | FC Parentis (9) | |
| 171. | SC Taron Sévignacq (11) | 0–3 | US Portugais Pau (7) | |
| 172. | Cazaux Olympique (9) | 1–3 | Seignosse-Capbreton-Soustons FC (7) | |
| 173. | RC Dax (11) | 0–5 | FC Lescar (6) | |
| 174. | AL Poey-de-Lescar (7) | 3–5 | Elan Boucalais (7) | |
| 175. | ES Meillon-Assat-Narcastet (8) | 3–1 | JS Teichoise (9) | |
| 176. | Sud Gironde FC (10) | 2–2 | FC Saint-Martin-de-Seignanx (8) | |
| 177. | ES Pyrénéenne (10) | 2–2 | SC Arthez Lacq Audejos (8) | |
| 178. | FC Lacajunte-Tursan (9) | 2–5 | CA Sallois (9) | |
| 179. | Ardanavy FC (11) | 0–0 | Andernos Sport FC (7) | |
| 180. | Baiona FC (10) | 1–4 | Arin Luzien (6) | |
| 181. | ES Audenge (7) | 2–3 | FC Doazit (7) | |
| 182. | CS Lantonnais (8) | 1–0 | JA Dax (7) | |
| 183. | Carresse Salies FC (10) | 0–3 | FC La Ribère (8) | |
| 184. | FC Belin-Béliet (8) | 3–0 | Hasparren FC (8) | |
| 185. | Pardies Olympique (8) | 1–1 | Hiriburuko Ainhara (6) | |
| 186. | AS Artix (8) | 0–2 | FC Bassin d'Arcachon (6) | |
| 187. | US Castétis-Gouze (9) | 3–2 | FC Artiguelouve-Arbus-Aubertin (10) | |
| 188. | ES Nay-Vath-Vielha (9) | 9–0 | FC Morcenx-Arengosse (8) |
These matches were played on 17, 18 and 19 September 2021.[7]
| 1. | ES Meillon-Assat-Narcastet (8) | 1–4 | Aviron Bayonnais FC (5) | |
| 2. | ES Beaumont-Saint-Cyr (7) | 2–2 | ES Aubinrorthais (8) | |
| 3. | Espérance Terves (8) | 2–2 | ES Oyré-Dangé (9) | |
| 4. | Montpon-Ménesplet FC (8) | 1–2 | Jeunesse Villenave (6) | |
| 5. | FC Airvo Saint-Jouin (9) | 1–1 | EF Le Tallud (7) | |
| 6. | FC Bassin d'Arcachon (6) | 1–0 | Hiriburuko Ainhara (6) | |
| 7. | JS Nieuil l'Espoir (8) | 0–2 | Thouars Foot 79 (6) | |
| 8. | Seignosse-Capbreton-Soustons FC (7) | 2–2 | FC Luy de Béarn (8) | |
| 9. | FC des Graves (7) | 3–3 | Croisés Saint-André Bayonne (7) | |
| 10. | FC des Portes de l'Entre-Deux-Mers (6) | 2–0 | US Bouscataise (7) | |
| 11. | SS Sainte-Féréole (8) | 1–4 | AS Aixoise (7) | |
| 12. | UES Montmorillon (6) | 0–5 | Stade Poitevin FC (5) | |
| 13. | US Marennaise (8) | 1–0 | FC Chauray (6) | |
| 14. | CO Coulouniex-Chamiers (9) | 2–3 | UA Cognac (5) | |
| 15. | La Ligugéenne Football (7) | 1–1 | SO Châtellerault (5) | |
| 16. | ACG Foot Sud 86 (10) | 0–1 | CA Saint-Savin-Saint-Germain (7) | |
| 17. | US Chasseneuil (10) | 1–4 | FC Nord 17 (8) | |
| 18. | FC Saint-Vincent-de-Paul (9) | 2–1 | SC Saint-Pierre-du-Mont (7) | |
| 19. | JA Biarritz (7) | 0–1 | FC Doazit (7) | |
| 20. | Capaunis ASPTT FC (8) | 4–2 | AS Cabariot (8) | |
| 21. | US Portugais Pau (7) | 2–1 | SA Mérignac (6) | |
| 22. | ES Ardin (9) | 1–0 | Valence-en-Poitou OC (10) | |
| 23. | SC Saint-Jean-d'Angély (6) | 3–1 | FC Périgny (7) | |
| 24. | EF Aubussonnais (8) | 2–1 | Tulle Football Corrèze (7) | |
| 25. | Fontafie FC (11) | 2–0 | US Abzac (11) | |
| 26. | SC Verrières (9) | 0–1 | US Migné-Auxances (7) | |
| 27. | FC Thenon-Limeyrat-Fossemagne (7) | 1–4 | Alliance Foot 3B (8) | |
| 28. | Périgueux Foot (10) | 1–7 | US Lormont (6) | |
| 29. | AS Nontron-Saint-Pardoux (7) | 5–0 | FC Pays de Mareuil (8) | |
| 30. | JS Sireuil (7) | 3–3 | FC Sévigné Jonzac-Saint-Germain (8) | |
| 31. | Arin Luzien (6) | 1–1 | Union Saint-Bruno (7) | |
| 32. | SA Mauléonais (8) | 2–2 | FC Lescar (6) | |
| 33. | SC Arthez Lacq Audejos (8) | 1–2 | FC Tartas Saint-Yaguen (5) | |
| 34. | CS Saint-Michel-sur-Charente (9) | 6–1 | ES Saintes (7) | |
| 35. | CS Feytiat (6) | 1–0 | FC Charente Limousine (7) | |
| 36. | FC Cornilois-Fortunadais (9) | 0–4 | ES Guérétoise (6) | |
| 37. | Rochefort FC (7) | 0–2 | AAAM Laleu-La Pallice (8) | |
| 38. | ES Boulazac (6) | 0–0 | Royan Vaux AFC (6) | |
| 39. | ESA Brive (6) | 1–1 | JA Isle (6) | |
| 40. | FC Argentat (8) | 1–4 | FC Fontaine-le-Comte (8) | |
| 41. | AS Jugeals-Noailles (9) | 0–1 | US Donzenac (7) | |
| 42. | USA Montbronn (10) | 0–6 | CS Boussac (8) | |
| 43. | AS Saint-Junien (8) | 0–3 | Limoges Football (9) | |
| 44. | FC Portes d'Océan 17 (9) | 3–2 | AS Saint-Yrieix (9) | |
| 45. | ASSA Pays du Dropt (8) | 2–0 | ES Blanquefort (6) | |
| 46. | FC Parentis (9) | 0–2 | CS Lantonnais (8) | |
| 47. | Stade Ruffec (7) | 3–1 | AS Châteauneuf-Neuvic (8) | |
| 48. | FC Belin-Béliet (8) | 5–0 | ES Nay-Vath-Vielha (9) | |
| 49. | La Brède FC (6) | 2–1 | Andernos Sport FC (7) | |
| 50. | Coqs Rouges Bordeaux (7) | 1–1 | US Lège Cap Ferret (5) | |
| 51. | US Port Sainte-Marie Feugarolles (10) | 0–2 | US La Catte (7) | |
| 52. | FC Mascaret (6) | 1–2 | FC Grand Saint-Emilionnais (7) | |
| 53. | ES Bruges (10) | 1–2 | FC Estuaire Haute Gironde (6) | |
| 54. | Targon-Soulignac FC (9) | 0–6 | Stade Bordelais (5) | |
| 55. | Stade Blayais (11) | 1–3 | FCE Mérignac Arlac (6) | |
| 56. | FC Pays Aurossais (8) | 1–1 | FC Sud 17 (9) | |
| 57. | CA Carignanais (11) | 0–1 | FC Côteaux Libournais (8) | |
| 58. | Bordeaux Étudiants CF (10) | 1–5 | Stade Saint-Médardais (7) | |
| 59. | US Virazeil-Puymiclan (9) | 2–2 | FC Cœur Médoc Atlantique (7) | |
| 60. | Athlético Vernois (10) | 1–7 | US Mussidan-Saint Medard (6) | |
| 61. | Sud Gironde FC (10) | 0–4 | Labenne OSC (8) | |
| 62. | Langon FC (7) | 1–1 | CA Béglais (7) | |
| 63. | CA Sallois (9) | 6–2 | FC La Ribère (8) | |
| 64. | Confluent Football 47 (7) | 3–1 | Elan Boucalais (7) | |
| 65. | AS Facture-Biganos Boïens (8) | 0–3 | Genêts Anglet (5) | |
| 66. | SAG Cestas (6) | 6–3 | Stade Ygossais (7) | |
| 67. | FC Vouneuil-sous-Biard-Béruges (10) | 4–0 | Gati-Foot (10) | |
| 68. | AS Périgné (12) | 1–4 | RC Parthenay Viennay (7) | |
| 69. | US Veyrac (10) | 0–8 | AS Gouzon (7) | |
| 70. | US Bazeillaise (11) | 3–0 | SJ Macaudaise (9) | |
| 71. | AS Le Taillan (8) | 4–1 | FC Vallée du Lot (7) | |
| 72. | Breuil-Magné FC (11) | 2–3 | US Chancelade/Marsac (9) | |
| 73. | AS Mazères-Uzos-Rontignan (8) | 1–1 | US Castétis-Gouze (9) | |
| 74. | ES Linars (9) | 0–0 | Aviron Boutonnais (9) | |
| 75. | UA Niort Saint-Florent (7) | 2–1 | AS Mignaloux-Beauvoir (7) | |
| 76. | ES Trois Cités Poitiers (9) | 3–2 | CS Naintré (7) | |
| 77. | FC Pays Argentonnais (9) | 3–3 | US Lezay (10) | |
| 78. | OC Sommières Saint-Romain (11) | 0–3 | FC Bressuire (5) | |
| 79. | ES Brûlain (10) | 1–4 | US Saint-Sauveur (7) | |
| 80. | US Vicq-sur-Gartempe (8) | 2–0 | FC Smarves Iteuil (9) | |
| 81. | AS Portugais Cerizay (10) | 1–1 | CO Cerizay (8) | |
| 82. | ES Clussais (11) | 0–4 | CA Neuville (5) | |
| 83. | FC Usson-Isle (9) | 1–2 | SA Moncoutant (7) | |
| 84. | FC Saint-Jean-Missé (11) | 2–1 | Avenir Autize (11) | |
| 85. | US Thuré-Besse (10) | 2–6 | ES Buxerolles (6) | |
| 86. | AS Puymoyen (8) | 2–1 | FC Périgord Centre (8) | |
| 87. | Étoile Maritime FC (7) | 2–0 | CS Leroy Angoulême (7) | |
| 88. | FC Loubesien (9) | 3–2 | FC Marmande 47 (6) | |
| 89. | ACS La Rochelle (10) | 3–0 | ASFC Vindelle (8) | |
| 90. | Limens JSA (8) | 7–1 | UAS Verdille (9) | |
| 91. | FC Bassimilhacois (9) | 1–3 | ES La Rochelle (6) | |
| 92. | Saint-Palais SF (8) | 1–3 | FC Libourne (5) | |
| 93. | Limoges Landouge (7) | 0–1 | US Chauvigny (5) | |
| 94. | ES Bénévent-Marsac (9) | 1–0 | CA Chamboulive (9) | |
| 95. | ES Brion-Saint-Secondin (10) | 1–3 | AS Nexon (9) | |
| 96. | Boisseuil FC (10) | 1–3 | ES Marchoise (7) | |
| 97. | ASV Malemort (9) | 0–0 | SC Verneuil-sur-Vienne (8) | |
| 98. | AS Panazol (7) | 5–0 | ES Beaubreuil (7) | |
| 99. | US Allemans-du-Dropt (11) | 0–8 | FC Saint André-de-Cubzac (7) | |
| 100. | ES Eysinaise (9) | 1–2 | FC Saint-Médard-en-Jalles (6) |
These matches were played on 2 and 3 October 2021.[8]
| 1. | Espérance Terves (8) | 0–6 | CA Neuville (5) | |
| 2. | ES Bénévent-Marsac (9) | 3–7 | AS Aixoise (7) | |
| 3. | AS Gouzon (7) | 2–3 | Trélissac-Antonne Périgord FC (4) | |
| 4. | Stade Bordelais (5) | 4–1 | UA Cognac (5) | |
| 5. | FC des Portes de l'Entre-Deux-Mers (6) | 0–2 | Bergerac Périgord FC (4) | |
| 6. | Limoges Football (9) | 3–6 | ES Guérétoise (6) | |
| 7. | AAAM Laleu-La Pallice (8) | 0–1 | SO Châtellerault (5) | |
| 8. | ES Boulazac (6) | 1–1 | AS Panazol (7) | |
| 9. | FC Luy de Béarn (8) | 0–3 | FC Doazit (7) | |
| 10. | ES La Rochelle (6) | 2–2 | RC Parthenay Viennay (7) | |
| 11. | FC Estuaire Haute Gironde (6) | 0–3 | FC Saint André-de-Cubzac (7) | |
| 12. | FC Saint-Vincent-de-Paul (9) | 3–2 | Croisés Saint-André Bayonne (7) | |
| 13. | CO Cerizay (8) | 1–1 | UA Niort Saint-Florent (7) | |
| 14. | FC Airvo Saint-Jouin (9) | 1–3 | US Vicq-sur-Gartempe (8) | |
| 15. | ES Buxerolles (6) | 2–2 | Étoile Maritime FC (7) | |
| 16. | Capaunis ASPTT FC (8) | 0–2 | FC Bressuire (5) | |
| 17. | US Migné-Auxances (7) | 4–0 | FC Nord 17 (8) | |
| 18. | FC Portes d'Océan 17 (9) | 2–3 | FC Grand Saint-Emilionnais (7) | |
| 19. | ASSA Pays du Dropt (8) | 1–1 | SC Saint-Jean-d'Angély (6) | |
| 20. | Aviron Boutonnais (9) | 1–1 | ES Ardin (9) | |
| 21. | Labenne OSC (8) | 1–1 | Coqs Rouges Bordeaux (7) | |
| 22. | SA Mauléonais (8) | 3–1 | La Brède FC (6) | |
| 23. | CS Saint-Michel-sur-Charente (9) | 2–2 | ESA Brive (6) | |
| 24. | CS Boussac (8) | 2–1 | SC Verneuil-sur-Vienne (8) | |
| 25. | CA Saint-Savin-Saint-Germain (7) | 3–1 | US Donzenac (7) | |
| 26. | EF Aubussonnais (8) | 0–3 | Stade Poitevin FC (5) | |
| 27. | CS Feytiat (6) | 2–0 | Stade Ruffec (7) | |
| 28. | Fontafie FC (11) | 0–6 | AS Puymoyen (8) | |
| 29. | US La Catte (7) | 1–3 | US Marennaise (8) | |
| 30. | FC Côteaux Libournais (8) | 3–3 | FC Loubesien (9) | |
| 31. | AS Le Taillan (8) | 1–0 | FC Saint-Médard-en-Jalles (6) | |
| 32. | US Virazeil-Puymiclan (9) | 1–3 | AS Nontron-Saint-Pardoux (7) | |
| 33. | Alliance Foot 3B (8) | 1–4 | FC Libourne (5) | |
| 34. | US Bazeillaise (11) | 3–4 | JS Sireuil (7) | |
| 35. | US Chancelade/Marsac (9) | 1–4 | US Lormont (6) | |
| 36. | ES Trois Cités Poitiers (9) | 2–1 | Thouars Foot 79 (6) | |
| 37. | FC Vouneuil-sous-Biard-Béruges (10) | 1–4 | SA Moncoutant (7) | |
| 38. | ACS La Rochelle (10) | 0–1 | ES Beaumont-Saint-Cyr (7) | |
| 39. | FC Saint-Jean-Missé (11) | 2–3 | US Saint-Sauveur (7) | |
| 40. | FC Pays Argentonnais (9) | 0–4 | Angoulême Charente FC (4) | |
| 41. | Limens JSA (8) | 4–2 | US Mussidan-Saint Medard (6) | |
| 42. | AS Nexon (9) | 0–1 | ES Marchoise (7) | |
| 43. | FC Fontaine-le-Comte (8) | 0–5 | US Chauvigny (5) | |
| 44. | FC Tartas Saint-Yaguen (5) | 1–2 | FC Bassin d'Arcachon (6) | |
| 45. | AS Mazères-Uzos-Rontignan (8) | 0–1 | FCE Mérignac Arlac (6) | |
| 46. | FC Pays Aurossais (8) | 0–3 | US Portugais Pau (7) | |
| 47. | Confluent Football 47 (7) | 0–2 | Genêts Anglet (5) | |
| 48. | Stade Saint-Médardais (7) | 3–2 | Stade Montois (4) | |
| 49. | SAG Cestas (6) | 3–0 | Arin Luzien (6) | |
| 50. | CA Sallois (9) | 1–1 | Langon FC (7) | |
| 51. | FC Belin-Béliet (8) | 1–4 | Jeunesse Villenave (6) | |
| 52. | CS Lantonnais (8) | 2–1 | Aviron Bayonnais FC (5) |
These matches were played on 16 and 17 October 2021.[9]
| 1. | Stade Poitevin FC (5) | 2–2 | SO Châtellerault (5) | |
| 2. | ES La Rochelle (6) | 3–1 | CA Saint-Savin-Saint-Germain (7) | |
| 3. | ES Ardin (9) | 0–4 | ESA Brive (6) | |
| 4. | ES Marchoise (7) | 1–5 | US Chauvigny (5) | |
| 5. | US Marennaise (8) | 1–1 | AS Puymoyen (8) | |
| 6. | CS Boussac (8) | 1–2 | CS Feytiat (6) | |
| 7. | AS Aixoise (7) | 0–3 | CA Neuville (5) | |
| 8. | US Portugais Pau (7) | 0–6 | Bergerac Périgord FC (4) | |
| 9. | Labenne OSC (8) | 1–2 | SAG Cestas (6) | |
| 10. | FC Doazit (7) | 2–1 | Jeunesse Villenave (6) | |
| 11. | Langon FC (7) | 3–2 | JS Sireuil (7) | |
| 12. | FCE Mérignac Arlac (6) | 0–0 | Trélissac-Antonne Périgord FC (4) | |
| 13. | Limens JSA (8) | 6–1 | SA Mauléonais (8) | |
| 14. | FC Grand Saint-Emilionnais (7) | 1–2 | Stade Bordelais (5) | |
| 15. | FC Saint-Vincent-de-Paul (9) | 1–1 | FC Bassin d'Arcachon (6) | |
| 16. | FC Saint André-de-Cubzac (7) | 1–1 | AS Le Taillan (8) | |
| 17. | ASSA Pays du Dropt (8) | 0–2 | US Lormont (6) | |
| 18. | AS Panazol (7) | 1–1 | ES Buxerolles (6) | |
| 19. | ES Trois Cités Poitiers (9) | 1–4 | ES Guérétoise (6) | |
| 20. | US Vicq-sur-Gartempe (8) | 1–2 | FC Bressuire (5) | |
| 21. | UA Niort Saint-Florent (7) | 1–5 | Angoulême Charente FC (4) | |
| 22. | SA Moncoutant (7) | 3–1 | US Migné-Auxances (7) | |
| 23. | ES Beaumont-Saint-Cyr (7) | 4–1 | US Saint-Sauveur (7) | |
| 24. | FC Côteaux Libournais (8) | 1–2 | CS Lantonnais (8) | |
| 25. | AS Nontron-Saint-Pardoux (7) | 1–1 | Genêts Anglet (5) | |
| 26. | Stade Saint-Médardais (7) | 3–3 | FC Libourne (5) |
| 1. | Limens JSA (8) | 3–0 | FC Doazit (7) | |
| 2. | CS Feytiat (6) | 2–1 | FC Bassin d'Arcachon (6) | |
| 3. | ES La Rochelle (6) | 0–1 | Bergerac Périgord FC (4) | |
| 4. | Langon FC (7) | 0–2 | Stade Poitevin FC (5) | |
| 5. | SAG Cestas (6) | 2–1 | FC Bressuire (5) | |
| 6. | AS Nontron-Saint-Pardoux (7) | 0–3 | FC Libourne (5) | |
| 7. | AS Le Taillan (8) | 1–1 | ESA Brive (6) | |
| 8. | US Lormont (6) | 0–2 | Stade Bordelais (5) | |
| 9. | AS Panazol (7) | 2–1 | SA Moncoutant (7) | |
| 10. | ES Guérétoise (6) | 2–0 | ES Beaumont-Saint-Cyr (7) | |
| 11. | CS Lantonnais (8) | 1–2 | US Chauvigny (5) | |
| 12. | AS Puymoyen (8) | 0–6 | Trélissac-Antonne Périgord FC (4) | |
| 13. | Angoulême Charente FC (4) | 1–0 | CA Neuville (5) |