The 2021–22 Coupe de France preliminary rounds, Bourgogne-Franche-Comté was the qualifying competition to decide which teams from the leagues of the Bourgogne-Franche-Comté region of France took part in the main competition from the seventh round.
A total of eight teams qualified from the Bourgogne-Franche-Comté preliminary rounds.[1] In 2020–21, UF Mâconnais progressed furthest in the main competition, reaching the round of 64 before losing to FC Saint-Louis Neuweg.[2]
On 8 July 2021, the league declared that 408 teams entered from the region, with 324 entering at the first round stage, 58 exempt to the second round (31 from Régionale 2 and all teams from Régionale 1). 12 Championnat National 3 teams entered at the third round stage, 3 Championnat National 2 teams at the fourth round stage and the remaining 8 clubs being part of the main draw.[3]
The first round draw was published on 9 July 2021.[4] The second round draw was published on 24 August 2021.[5] The third round draw was published on 31 August 2021.[6] The fourth round draw was published on 21 September 2021.[7] The fifth round draw was made on 5 October 2021.[8] The sixth round draw was made on 21 October 2021.[9]
These matches were played on 20, 21 and 22 August 2021.[10]
| 1. | AS Méziré-Fesches-le-Châtel (8) | 4–2 | FC Colombe (9) | |
| 2. | FC Pays de Luxeuil (11) | 2–5 | SG Héricourt (8) | |
| 3. | Rougemont Concorde (9) | 1–1 | FC Pays Minier (10) | |
| 4. | FC Giro-Lepuix (8) | 4–0 | Olympique Courcelles-lès-Montbéliard (9) | |
| 5. | AS Chèvremont (11) | 3–4 | AS Nord Territoire (9) | |
| 6. | AS Présentevillers-Sainte-Marie (10) | 1–5 | UOP Mathay (10) | |
| 7. | USC Sermamagny (10) | 0–7 | AS Mélisey-Saint Barthélemy (8) | |
| 8. | ES Exincourt-Taillecourt (9) | 4–2 | AS Rougegoutte (10) | |
| 9. | US Frotey-lès-Vesoul (9) | 3–0 | FC Forges Audincourt (10) | |
| 10. | US Pusey (10) | 0–8 | US Arcey (10) | |
| 11. | GLS Club 90 (11) | 0–1 | FC L'Isle-sur-le-Doubs (8) | |
| 12. | AS Fougerolles (9) | 0–1 | US Sous-Roches (8) | |
| 13. | AS Berche-Dampierre-Etouvans (12) | 1–8 | FC Seloncourt (10) | |
| 14. | Longevelle SC (9) | 2–1 | ASC Montbéliard (10) | |
| 15. | FAC Lougres (11) | 2–3 | SC Saint Loup-Corbenay-Magnoncourt (8) | |
| 16. | AS Sainte Suzanne (12) | 1–3 | ES Trévillers-Thiébouhans (11) | |
| 17. | ES Réchésy (11) | 1–2 | AS Guyans-Vennes (9) | |
| 18. | FC Suarce (12) | 2–0 | FC Plaimbois-du-Miroir (10 | |
| 19. | US Roches-lès-Blamont (11) | 1–2 | SR Delle (8) | |
| 20. | AS Orchamps-Val de Vennes (8) | 2–1 | US Larians-et-Munans (7) | |
| 21. | CS Beaucourt (9) | 0–3 | AS Essert (10) | |
| 22. | ES Pays Maîchois (8) | 2–0 | ASFC Belfort (9) | |
| 23. | AS Feule-Solemont (11) | 1–3 | AS Courtefontaine-Les Plains (10) | |
| 24. | ES Charquemont (11) | 0–1 | AS Frambouhans (11) | |
| 25. | FC Le Russey (11) | 1–1 | US Les Fontenelles (10) | |
| 26. | SCM Valdoie (9) | 3–0 | AS Pierrefontaine et Laviron (10) | |
| 27. | US Saint Hippolyte (11) | 3–2 | US Les Fins (11) | |
| 28. | AS Danjoutin-Andelnans-Méroux (8) | 2–0 | AS Hérimoncourt (9) | |
| 29. | AS Dambelin (12) | 2–1 | FC Bourogne (12) | |
| 30. | FC Villars-sous-Écot/Saint-Maurice/Blussans (10) | 4–3 | RC Voujeaucourt (10) | |
| 31. | AS Montandon (12) | 0–0 | ASL Autechaux-Roide (9) | |
| 32. | US Les Quatre Monts (11) | 2–1 | ES Les Fonges 91 (9) | |
| 33. | AS Haut Lison (11) | 2–1 | ES Doubs (8) | |
| 34. | ASC Amathay-Longeville (12) | 0–8 | ES Les Sapins (10) | |
| 35. | RC Chaux-du-Dombief (10) | 4–0 | ES Sirod (9) | |
| 36. | AS Avoudrey (10) | 1–1 | Amancey-Bolandoz-Chantrans Foot (10) | |
| 37. | ES Saugette Entre-Roches (9) | 4–0 | AS Mont d'Usiers (10) | |
| 38. | ES Dannemarie (9) | 2–1 | AS Etalans Vernierfontaine (10) | |
| 39. | Arcade Foot (8) | 0–2 | CS Frasne (9) | |
| 40. | FC Massif Haut Doubs (11) | 4–0 | AS La Rochette (11) | |
| 41. | AS Fort-du-Plasne (10) | 0–2 | SC Villers-le-Lac (8) | |
| 42. | Entente Le Châteleu (10) | 0–3 | AS Château de Joux (9) | |
| 43. | US Laveron (11) | 3–3 | FC Liévremont-Arçon (9) | |
| 44. | Drugeon Sports (11) | 4–0 | Étoile Saugette La Chaux de Gilley (10) | |
| 45. | US Crotenay Combe d'Ain (10) | 3–1 | FC Haut Jura (8) | |
| 46. | FC Lac-Remoray-Vaux (10) | 3–0 | US Foncine (11) | |
| 47. | AS Genlis (8) | 5–0 | ALC Longvic (8) | |
| 48. | FR Archelange-Gredisans-Menotey (11) | 0–6 | CCS Val d'Amour Mont-sous-Vaudrey (7) | |
| 49. | CS Auxonnais (8) | 2–1 | EF Villages (8) | |
| 50. | US Trois Monts (9) | 2–1 | ISS Pleure (10) | |
| 51. | ASDDOM Dijon (11) | 2–5 | FC Saulon-Corcelles (9) | |
| 52. | FC Aiserey-Izeure (9) | 0–0 | AS Saint Usage Saint-Jean-de-Losne (8) | |
| 53. | FC Remilly (11) | 8–1 | AS Choisey (11) | |
| 54. | FC Neuilly-Crimolois Sennecey (10) | 6–0 | AS Montbarrey (11) | |
| 55. | FR Rahon (11) | 0–5 | Jura Stad' FC (8) | |
| 56. | AS Seurre (12) | 0–10 | FC Ouges-Fénay (9) | |
| 57. | AS Foucherans (9) | 3–0 | FC Plaine 39 (10) | |
| 58. | ESJA Myon-Chay Intercommunal (11) | 1–2 | ASC Velotte (10) | |
| 59. | AS Plateau de La Barêche (11) | 4–0 | FC Amagney Marchaux (11) | |
| 60. | US Avanne-Aveney (10) | 0–3 | FC Grand Besançon (8) | |
| 61. | FC Chatillon-Devecey (11) | 0–4 | FC Rochefort Athletic (8) | |
| 62. | ASC Besançon Mahoraise (10) | 1–2 | FC Montfaucon-Morre-Gennes-La Vèze (7) | |
| 63. | FC Brenne-Orain (10) | 1–3 | PS Dole-Crissey (9) | |
| 64. | US Prés de Vaux (11) | 1–4 | FC Val de Loue (9) | |
| 65. | AS Besançon Espérance (12) | 0–3 | Jura Nord Foot (10) | |
| 66. | Thise-Chalezeule FC (10) | 3–0 | US Grandmont (11) | |
| 67. | AS Besançon Ouest (12) | 2–2 | US Doubs Sud (10) | |
| 68. | FC Aiglepierre (9) | 0–3 | AS Sâone-Mamirolle (9) | |
| 69. | AS Beure (10) | 3–2 | FC Mouchard-Arc-et-Senans (10) | |
| 70. | FC Émagny Pin (10) | 4–1 | FC Premier Plateau (9) | |
| 71. | AS Poussots (11) | 1–1 | SC Jussey (9) | |
| 72. | CSL Chenôve (12) | 0–3 | FC Grésilles (10) | |
| 73. | Tilles FC (9) | 5–1 | FC Les 2 Vels (10) | |
| 74. | US Marey-Cussey (10) | 4–2 | US Brazey-en-Plaine (11) | |
| 75. | AS Dijon Toison d'Or (12) | 1–8 | ES Marnaysienne (9) | |
| 76. | FC Aignay Baigneux (11) | 7–0 | FFM La Romaine (11) | |
| 77. | FC Ahuy (11) | 3–0 | FC Sennecey-lès-Dijon (12) | |
| 78. | ASFC Daix (10) | 0–3 | FC Mirebellois-Pontailler-Lamarche (8) | |
| 79. | FC Jeunesse Mahoraise (11) | 3–4 | Espérance Arc-Gray (8) | |
| 80. | FC Vingeanne (9) | 1–1 | RC Saônois (9) | |
| 81. | Val de Norge FC (10) | 5–0 | Spartak Bressey (10) | |
| 82. | Dinamo Dijon (11) | 0–6 | ES Fauverney-Rouvres-Bretenière (7) | |
| 83. | Auxerre Sports Citoyens (11) | 1–4 | US Semur-Époisses (9) | |
| 84. | ASUC Migennes (8) | 1–1 | AS Gurgy (9) | |
| 85. | AS Saint-Bris-le-Vineux (9) | 1–8 | AS Magny (7) | |
| 86. | ES Héry (9) | 2–0 | UF Tonnerrois (10) | |
| 87. | FC Champs-sur-Yonne (9) | 2–3 | Montbard Venarey (9) | |
| 88. | AS Chablis (8) | 2–1 | Monéteau FC (9) | |
| 89. | AJ Sautourienne (10) | 2–0 | Entente Châtel-Gérard Nucerien (9) | |
| 90. | FC Saint Rémy les Montbard (9) | 1–2 | US Varennes (9) | |
| 91. | AS Précy (12) | 0–18 | Union Châtillonniase Colombine (10) | |
| 92. | SC Vitteaux (11) | 0–3 | FC Aigles Auxerre (12) | |
| 93. | AS Varzy (11) | 0–6 | US Toucycoise (9) | |
| 94. | US Joigny (10) | 0–2 | CA Saint-Georges (8) | |
| 95. | CSP Charmoy (12) | 3–0 | Cosnois FC (11) | |
| 96. | FC Coulanges-la-Vineuse (10) | 0–3 | US Dionysienne (10) | |
| 97. | FC Cheu | 0–3 | US Cerisiers (8) | |
| 98. | ASC Pougues (9) | 3–2 | FC Gatinais en Bourgogne (10) | |
| 99. | JS Saint-Révérien (11) | 0–5 | Jeunesse Sénonaise (10) | |
| 100. | USC Charny (12) | 1–2 | AS Montoise (9) | |
| 101. | AS Pouilly-sur-Loire (11) | 0–1 | FC Chevannes (9) | |
| 102. | Saint-Fargeau SF (10) | 4–0 | SC Gron Véron (10) | |
| 103. | FC Fleury-la-Vallée (10) | 1–2 | Amicale Franco-Portugais Sens (9) | |
| 104. | ES Saint-Germain-du-Plaine-Baudrières (10) | 2–1 | Entente Sud Revermont (8) | |
| 105. | FC Saint-Lupicin (12) | 2–2 | FC Charette (10) | |
| 106. | Olympique Montmorot (9) | 0–8 | RC Bresse Sud (8) | |
| 107. | US Revermontaise (10) | 1–4 | JS Simard (11) | |
| 108. | AS Tournus (12) | 2–4 | FC Petite Montagne (10) | |
| 109. | FC Courlaoux (12) | 0–6 | US Coteaux de Seille (8) | |
| 110. | FC Macornay Val de Sorne (10) | 4–4 | IS Bresse Nord (10) | |
| 111. | FC Pont de la Pyle (10) | 1–1 | AS Condal-Dommartin (11) | |
| 112. | AS Sornay (8) | 4–3 | SC Châteaurenaud (9) | |
| 113. | AS Vaux-lès-Saint-Claude (9) | 5–2 | AFC Cuiseaux-Champagnat (10) | |
| 114. | US Lessard-en-Bresse (9) | 1–3 | IS Saint-Usuge (9) | |
| 115. | ES Branges (10) | 0–0 | FC Épervans (10) | |
| 116. | AS Aromas (11) | 1–1 | CS Mervans (8) | |
| 117. | FC Hurigny (11) | 1–3 | Dun Sornin Chauffailles Brionnais (9) | |
| 118. | Sancé FC (10) | 1–3 | SR Clayettois (8) | |
| 119. | FC La Roche-Vineuse (9) | 7–1 | JS Mâconnaise (8) | |
| 120. | JS Crechoise (10) | 3–1 | FC Clessé | |
| 121. | FC Sennecé-lès-Mâcon (9) | 0–3 | US Sennecey-le-Grand et son Canton (8) | |
| 122. | FC Dompierre-Matour (10) | 0–2 | Joncy Salornay Val de Guye (10) | |
| 123. | AS Laizé (11) | 0–7 | Mâcon FC (8) | |
| 124. | CS Tramayes (11) | 4–5 | US Cluny (8) | |
| 125. | Viré Lugny Haut Mâconnais (11) | 0–5 | RC Flacé Mâcon (10) | |
| 126. | ES Pays Charollais (10) | 0–4 | Digoin FCA (9) | |
| 127. | Génelard Perrecy FC (9) | 0–0 | US Bourbon-Lancy FPT (10) | |
| 128. | US Rigny-sur-Arroux (9) | 1–0 | JF Palingeois (9) | |
| 129. | AS Neuvyssois (10) | 1–0 | AS Saint-Vincent-Bragny (9) | |
| 130. | AS Charrin (10) | 1–3 | Sud Foot 71 (8) | |
| 131. | AS Vendenesse-sur-Arroux (11) | 1–3 | ES Toulon-sur-Arroux (10) | |
| 132. | Entente Antully Saint-Émiland Auxy (11) | 5–2 | AS Ciry-le-Noble (9) | |
| 133. | UF La Machine (8) | 5–0 | AS Guerigny Urzy (8) | |
| 134. | FC Château-Chinon-Arleuf (10) | 9–1 | USC Franco-Portugais Garchizy (10) | |
| 135. | US Coulanges-lès-Nevers (9) | 1–1 | FC Nevers 58 (8) | |
| 136. | CS Corbigeois (9) | 0–1 | AS Fourchambault (9) | |
| 137. | Chaulgnes FC (9) | 1–5 | Étoile Sud Nivernaise 58 (8) | |
| 138. | RC Nevers-Challuy Sermoise (8) | 0–1 | FC Nevers Banlay (9) | |
| 139. | FREP Luthenay (10) | 1–2 | FC Sud Loire Allier 09 (9) | |
| 140. | RC Maupas (12) | 0–1 | JS Marzy (9) | |
| 141. | US Saint-Pierre Foot 58 (10) | 3–0 | US Luzy-Millay (10) | |
| 142. | CF Talant (12) | 0–11 | Chalon ACF (8) | |
| 143. | AS Lacanche (10) | 3–0 | FC Verdunois (11) | |
| 144. | JS Chagnotine (12) | 0–3 | AS Châtenoy-le-Royal (8) | |
| 145. | SLF Sevrey (11) | 1–2 | ÉFC Demigny (10) | |
| 146. | US Buxynoise (9) | 3–2 | AS Varennes-le-Grand (10) | |
| 147. | US Meursault (8) | 3–0 | ASL Lux (9) | |
| 148. | JS Rully (9) | 6–4 | FC Autun (10) | |
| 149. | AS Cheminots Chagnotins (10) | 1–3 | ASC Plombières-Lès-Dijon (9) | |
| 150. | ASI Vougeot (11) | 0–0 | AS Pouilly-en-Auxois (8) | |
| 151. | FC Corgoloin-Ladoix (8) | 3–5 | AS Gevrey-Chambertin (9) | |
| 152. | Flamboyants Football Chalonnais (10) | 0–3 | Team Montceau Foot (9) | |
| 153. | US Savigny-Chassagne (10) | 3–5 | FC Marmagne (10) | |
| 154. | Montcenis FC (10) | 4–1 | CS Orion (11) | |
| 155. | Saint-Vallier Sport (10) | 4–2 | SC Etangois (10) | |
| 156. | Sassenay-Virey-Lessard-Fragnes (9) | 1–5 | FC Sombernon-Gissey (10) | |
| 157. | US Givry-Saint-Désert (10) | 1–1 | UFC de l'Ouche (11) | |
| 158. | AS Canton du Bligny-sur-Ouche (12) | 1–5 | AS Mellecey-Mercurey (10) | |
| 159. | FC Saint-Rémy (9) | 3–1 | FLL Gergy-Verjux (9) | |
| 160. | EJS Épinacoise (10) | 3–3 | FC Bois du Verne (11) | |
| 161. | FR Saint Marcel (7) | 8–0 | US Nolay (11) | |
| 162. | US Blanzy (9) | 2–2 | US Crissotine (9) |
These matches were played on 28 and 29 August 2021.[11]
| 1. | FC Seloncourt (10) | 3–2 | US Saint Hippolyte (11) | |
| 2. | FC Giro-Lepuix (8) | 1–1 | AS Orchamps-Val de Vennes (8) | |
| 3. | ES Trévillers-Thiébouhans (11) | 0–9 | FC L'Isle-sur-le-Doubs (8) | |
| 4. | Haute-Lizaine Pays d'Héricourt (7) | 3–3 | US Châtenois-les-Forges (7) | |
| 5. | AS Bavilliers (7) | 4–0 | US Sous-Roches (8) | |
| 6. | ES Exincourt-Taillecourt (9) | 0–4 | FC Vesoul (6) | |
| 7. | UOP Mathay (10) | 1–0 | Longevelle SC (9) | |
| 8. | FC Pays Minier (10) | 2–1 | AS Guyans-Vennes (9) | |
| 9. | AS Montandon (12) | 0–5 | AS Méziré-Fesches-le-Châtel (8) | |
| 10. | FC Villars-sous-Écot/Saint-Maurice/Blussans (10) | 0–3 | JS Lure (7) | |
| 11. | AS Dambelin (12) | 1–3 | US Les Écorces (7) | |
| 12. | AS Danjoutin-Andelnans-Méroux (8) | 1–2 | US Frotey-lès-Vesoul (9) | |
| 13. | US Arcey (10) | 5–2 | Bessoncourt Roppe Club Larivière (7) | |
| 14. | US Les Fontenelles (10) | 1–2 | SR Delle (8) | |
| 15. | AS Essert (10) | 1–3 | SG Héricourt (8) | |
| 16. | SC Saint Loup-Corbenay-Magnoncourt (8) | 0–6 | AS Belfort Sud (6) | |
| 17. | SCM Valdoie (9) | 2–2 | AS Courtefontaine-Les Plains (10) | |
| 18. | US Sochaux (7) | 3–3 | US Pont-de-Roide (6) | |
| 19. | AS Mélisey-Saint Barthélemy (8) | 0–3 | AS Audincourt (6) | |
| 20. | AS Nord Territoire (9) | 0–5 | FC Noidanais (7) | |
| 21. | FC Suarce (12) | 1–3 | FC Bart (7) | |
| 22. | AS Frambouhans (11) | 0–9 | ES Pays Maîchois (8) | |
| 23. | AS Haut Lison (11) | 0–0 | ES Dannemarie (9) | |
| 24. | AS Château de Joux (9) | 0–1 | AS Levier (6) | |
| 25. | US Crotenay Combe d'Ain (10) | 1–2 | AS Avoudrey (10) | |
| 26. | ES Les Sapins (10) | 1–3 | Drugeon Sports (11) | |
| 27. | US Les Quatre Monts (11) | 2–2 | SC Villers-le-Lac (8) | |
| 28. | FC Massif Haut Doubs (11) | 0–8 | AS Baume-les-Dames (6) | |
| 29. | US Laveron (11) | 2–2 | RC Chaux-du-Dombief (10) | |
| 30. | FC Lac-Remoray-Vaux (10) | 1–2 | FC Champagnole (6) | |
| 31. | CS Frasne (9) | 0–3 | AS Ornans (6) | |
| 32. | ES Saugette Entre-Roches (9) | 1–1 | FCC La Joux (7) | |
| 33. | ASC Velotte (10) | 1–1 | FC Émagny Pin (10) | |
| 34. | FC Saulon-Corcelles (9) | 0–1 | Thise-Chalezeule FC (10) | |
| 35. | FC Grand Besançon (8) | 1–4 | US Saint-Vit (6) | |
| 36. | Jura Nord Foot (10) | 1–4 | Fontaine-lès-Dijon FC (7) | |
| 37. | AS Beure (10) | 0–3 | AS Perrouse (7) | |
| 38. | US Marey-Cussey (10) | 0–3 | US Rioz-Étuz-Cussey (7) | |
| 39. | AS Sâone-Mamirolle (9) | 1–3 | FC Montfaucon-Morre-Gennes-La Vèze (7) | |
| 40. | ES Marnaysienne (9) | 1–3 | Entente Roche-Novillars (6) | |
| 41. | AS Besançon Ouest (12) | 0–10 | Poligny-Grimont FC (7) | |
| 42. | FC Grésilles (10) | 1–4 | ES Fauverney-Rouvres-Bretenière (7) | |
| 43. | FC Aignay Baigneux (11) | 2–3 | AS Genlis (8) | |
| 44. | Espérance Arc-Gray (8) | 0–3 | PS Dole-Crissey (9) | |
| 45. | AS Plateau de La Barêche (11) | 1–3 | SC Jussey (9) | |
| 46. | FC Remilly (11) | 0–2 | FC 4 Rivières 70 (6) | |
| 47. | FC Mirebellois-Pontailler-Lamarche (8) | 1–2 | FC Rochefort Athletic (8) | |
| 48. | CS Auxonnais (8) | 1–1 | Tilles FC (9) | |
| 49. | FC Ouges-Fénay (9) | 2–0 | FC Aiserey-Izeure (9) | |
| 50. | RC Saônois (9) | 2–1 | FC Val de Loue (9) | |
| 51. | FC Neuilly-Crimolois Sennecey (10) | 4–1 | Val de Norge FC (10) | |
| 52. | FC Ahuy (11) | 0–8 | AEP Pouilley-les-Vignes (7) | |
| 53. | AS Chablis (8) | 2–1 | US Varennes (9) | |
| 54. | FC Chevannes (9) | 0–3 | AS Magny (7) | |
| 55. | US Toucycoise (9) | 1–0 | CA Saint-Georges (8) | |
| 56. | Amicale Franco-Portugais Sens (9) | 0–3 | Stade Auxerrois (6) | |
| 57. | Union Châtillonniase Colombine (10) | 5–0 | ES Héry (9) | |
| 58. | Jeunesse Sénonaise (10) | 4–4 | US Dionysienne (10) | |
| 59. | ASC Pougues (9) | 3–3 | Saint-Fargeau SF (10) | |
| 60. | Montbard Venarey (9) | 2–3 | ES Appoigny (7) | |
| 61. | AS Montoise (9) | 0–3 | ASUC Migennes (8) | |
| 62. | US Cerisiers (8) | 1–1 | AS Clamecy (7) | |
| 63. | CSP Charmoy (12) | 1–7 | FC Sens (6) | |
| 64. | Union Cosnoise Sportive (6) | 4–0 | Avallon FCO (6) | |
| 65. | FC Aigles Auxerre (12) | 0–2 | AJ Sautourienne (10) | |
| 66. | US Semur-Époisses (9) | 2–2 | US Cheminots Dijonnais (7) | |
| 67. | FC Pont de la Pyle (10) | 2–4 | AS Aromas (11) | |
| 68. | FC Saint-Lupicin (12) | 2–1 | FC Épervans (10) | |
| 69. | FC Petite Montagne (10) | 0–7 | Bresse Jura Foot (7) | |
| 70. | AS Vaux-lès-Saint-Claude (9) | 3–2 | ES Saint-Germain-du-Plaine-Baudrières (10) | |
| 71. | RC Bresse Sud (8) | 5–1 | AS Sagy (8) | |
| 72. | US Coteaux de Seille (8) | 2–1 | US Trois Monts (9) | |
| 73. | IS Bresse Nord (10) | 2–4 | Jura Stad' FC (8) | |
| 74. | AS Foucherans (9) | 1–5 | Jura Lacs Foot (6) | |
| 75. | JS Simard (11) | 0–3 | IS Saint-Usuge (9) | |
| 76. | CCS Val d'Amour Mont-sous-Vaudrey (7) | 2–2 | AS Sornay (8) | |
| 77. | RC Lons-le-Saunier (6) | 7–0 | Triangle d'Or Jura Foot (7) | |
| 78. | FC Nevers 58 (8) | 0–2 | US Saint-Sernin-du-Bois (6) | |
| 79. | US Bourbon-Lancy FPT (10) | 0–4 | UF La Machine (8) | |
| 80. | JS Marzy (9) | 0–4 | US Rigny-sur-Arroux (9) | |
| 81. | AS Neuvyssois (10) | 2–1 | Sud Foot 71 (8) | |
| 82. | US Cheminots Paray (6) | 0–1 | US La Charité (6) | |
| 83. | ES Toulon-sur-Arroux (10) | 0–8 | ASA Vauzelles (7) | |
| 84. | AS Saint-Benin (7) | 0–1 | AS Garchizy (6) | |
| 85. | Entente Antully Saint-Émiland Auxy (11) | 0–5 | Digoin FCA (9) | |
| 86. | AS Fourchambault (9) | 3–1 | US Saint-Pierre Foot 58 (10) | |
| 87. | CS Sanvignes (7) | 1–2 | Sud Nivernais Imphy Decize (6) | |
| 88. | FC Sud Loire Allier 09 (9) | 0–3 | FC Nevers Banlay (9) | |
| 89. | FC Château-Chinon-Arleuf (10) | 2–2 | Étoile Sud Nivernaise 58 (8) | |
| 90. | RC Flacé Mâcon (10) | 0–1 | FC La Roche-Vineuse (9) | |
| 91. | Joncy Salornay Val de Guye (10) | 0–7 | UF Mâconnais (6) | |
| 92. | Dun Sornin Chauffailles Brionnais (9) | 0–0 | AS Chapelloise (6) | |
| 93. | SR Clayettois (8) | 2–4 | JS Montchanin ODRA (7) | |
| 94. | US Cluny (7) | 5–2 | US Saint-Bonnet/La Guiche (7) | |
| 95. | Mâcon FC (8) | 2–2 | US Sennecey-le-Grand et son Canton (8) | |
| 96. | JS Crechoise (10) | 0–2 | AS Beaune (7) | |
| 97. | US Meursault (8) | 6–3 | Chalon ACF (8) | |
| 98. | AS Pouilly-en-Auxois (8) | 3–1 | CL Marsannay-la-Côte (7) | |
| 99. | FC Marmagne (10) | 1–3 | JO Le Creusot (7) | |
| 100. | AS Lacanche (10) | 0–9 | FC Chalon (6) | |
| 101. | FC Saint-Rémy (9) | 4–1 | US Buxynoise (9) | |
| 102. | JS Rully (9) | 1–2 | FR Saint Marcel (7) | |
| 103. | ASPTT Dijon (7) | 2–0 | ESA Breuil (7) | |
| 104. | Team Montceau Foot (9) | 5–2 | FC Sombernon-Gissey (10) | |
| 105. | UFC de l'Ouche (11) | 0–3 | Montcenis FC (10) | |
| 106. | ASC Plombières-Lès-Dijon (9) | 0–0 | Chevigny Saint-Sauveur (6) | |
| 107. | AS Gevrey-Chambertin (9) | 3–1 | Saint-Vallier Sport (10) | |
| 108. | ÉFC Demigny (10) | 2–3 | EJS Épinacoise (10) | |
| 109. | US Crissotine (9) | 1–1 | AS Châtenoy-le-Royal (8) | |
| 110. | AS Mellecey-Mercurey (10) | 2–7 | AS Quetigny (6) |
These matches were played on 18 and 19 September 2021.[12]
| 1. | RC Chaux-du-Dombief (10) | 1–2 | FC Noidanais (7) | |
| 2. | FC Seloncourt (10) | 0–6 | FC L'Isle-sur-le-Doubs (8) | |
| 3. | ES Dannemarie (9) | 0–11 | FC Morteau-Montlebon (5) | |
| 4. | AS Ornans (6) | 4–0 | FC Bart (7) | |
| 5. | FC Vesoul (6) | 0–1 | CA Pontarlier (5) | |
| 6. | US Arcey (10) | 2–4 | AS Levier (6) | |
| 7. | AS Avoudrey (10) | 0–2 | AS Belfort Sud (6) | |
| 8. | US Frotey-lès-Vesoul (9) | 2–4 | AS Méziré-Fesches-le-Châtel (8) | |
| 9. | ES Pays Maîchois (8) | 1–0 | AS Baume-les-Dames (6) | |
| 10. | Drugeon Sports (11) | 1–2 | SG Héricourt (8) | |
| 11. | FC Pays Minier (10) | 0–2 | FC Valdahon-Vercel (5) | |
| 12. | US Les Quatre Monts (11) | 0–3 | US Pont-de-Roide (6) | |
| 13. | JS Lure (7) | 1–1 | AS Orchamps-Val de Vennes (8) | |
| 14. | AS Audincourt (6) | 3–3 | AS Bavilliers (7) | |
| 15. | SCM Valdoie (9) | 1–1 | FCC La Joux (7) | |
| 16. | SR Delle (8) | 0–2 | US Les Écorces (7) | |
| 17. | UOP Mathay (10) | 2–2 | US Châtenois-les-Forges (7) | |
| 18. | FC Ouges-Fénay (9) | 1–4 | FC Grandvillars (5) | |
| 19. | Jura Stad' FC (8) | 0–1 | Tilles FC (9) | |
| 20. | AS Genlis (8) | 1–3 | RC Bresse Sud (8) | |
| 21. | AS Perrouse (7) | 0–10 | Racing Besançon (5) | |
| 22. | SC Jussey (9) | 0–1 | Poligny-Grimont FC (7) | |
| 23. | US Rioz-Étuz-Cussey (7) | 1–1 | FC Champagnole (6) | |
| 24. | Bresse Jura Foot (7) | 3–2 | AEP Pouilley-les-Vignes (7) | |
| 25. | Thise-Chalezeule FC (10) | 0–3 | Entente Roche-Novillars (6) | |
| 26. | FC Saint-Lupicin (12) | 0–8 | RC Lons-le-Saunier (6) | |
| 27. | CCS Val d'Amour Mont-sous-Vaudrey (7) | 3–1 | FC Rochefort Athletic (8) | |
| 28. | RC Saônois (9) | 0–1 | FC 4 Rivières 70 (6) | |
| 29. | FC Neuilly-Crimolois Sennecey (10) | 1–3 | ES Fauverney-Rouvres-Bretenière (7) | |
| 30. | ASC Velotte (10) | 1–4 | FC Montfaucon-Morre-Gennes-La Vèze (7) | |
| 31. | PS Dole-Crissey (9) | 0–3 | US Saint-Vit (6) | |
| 32. | IS Saint-Usuge (9) | 0–8 | Besançon Football (5) | |
| 33. | US Coteaux de Seille (8) | 8–0 | AS Vaux-lès-Saint-Claude (9) | |
| 34. | AS Aromas (11) | 1–8 | Jura Lacs Foot (6) | |
| 35. | AS Garchizy (6) | 1–1 | ASA Vauzelles (7) | |
| 36. | ASUC Migennes (8) | 0–4 | Stade Auxerrois (6) | |
| 37. | Étoile Sud Nivernaise 58 (8) | 1–1 | US Toucycoise (9) | |
| 38. | US Semur-Époisses (9) | 0–4 | Paron FC (5) | |
| 39. | AJ Sautourienne (10) | 0–4 | FC Sens (6) | |
| 40. | ASC Pougues (9) | 0–2 | Union Châtillonniase Colombine (10) | |
| 41. | UF La Machine (8) | 1–1 | FC Nevers Banlay (9) | |
| 42. | ES Appoigny (7) | 1–0 | FC Montceau Bourgogne (5) | |
| 43. | US Cerisiers (8) | 0–0 | FC Gueugnon (5) | |
| 44. | AS Fourchambault (9) | 1–1 | US La Charité (6) | |
| 45. | US Dionysienne (10) | 0–0 | Fontaine-lès-Dijon FC (7) | |
| 46. | AS Magny (7) | 2–4 | Union Cosnoise Sportive (6) | |
| 47. | AS Chablis (8) | 0–2 | Sud Nivernais Imphy Decize (6) | |
| 48. | AS Neuvyssois (10) | 3–0 | FC Saint-Rémy (9) | |
| 49. | Dun Sornin Chauffailles Brionnais (9) | 1–1 | US Cluny (7) | |
| 50. | ASC Plombières-Lès-Dijon (9) | 3–1 | AS Pouilly-en-Auxois (8) | |
| 51. | Montcenis FC (10) | 2–5 | Mâcon FC (8) | |
| 52. | AS Gevrey-Chambertin (9) | 0–2 | Is-Selongey Football (5) | |
| 53. | FC La Roche-Vineuse (9) | 2–3 | Team Montceau Foot (9) | |
| 54. | AS Beaune (7) | 1–2 | FC Chalon (6) | |
| 55. | US Meursault (8) | 0–5 | AS Quetigny (6) | |
| 56. | UF Mâconnais (6) | 7–0 | JO Le Creusot (7) | |
| 57. | ASPTT Dijon (7) | 0–2 | Jura Dolois Football (5) | |
| 58. | US Rigny-sur-Arroux (9) | 1–0 | JS Montchanin ODRA (7) | |
| 59. | EJS Épinacoise (10) | 0–8 | ASC Saint-Apollinaire (5) | |
| 60. | AS Châtenoy-le-Royal (8) | 3–1 | Digoin FCA (9) | |
| 61. | US Saint-Sernin-du-Bois (6) | 0–1 | FR Saint Marcel (7) |
These matches were played on 2 and 3 October 2021.[13]
| 1. | Union Châtillonniase Colombine (10) | 1–1 | UF La Machine (8) | |
| 2. | US Dionysienne (10) | 2–1 | Mâcon FC (8) | |
| 3. | Stade Auxerrois (6) | 0–3 | Louhans-Cuiseaux FC (4) | |
| 4. | ASA Vauzelles (7) | 1–3 | Union Cosnoise Sportive (6) | |
| 5. | AS Neuvyssois (10) | 1–3 | Paron FC (5) | |
| 6. | Sud Nivernais Imphy Decize (6) | 0–4 | Is-Selongey Football (5) | |
| 7. | FR Saint Marcel (7) | 3–0 | US Cerisiers (8) | |
| 8. | FC Chalon (6) | 2–0 | ES Appoigny (7) | |
| 9. | US Toucycoise (9) | 1–5 | US La Charité (6) | |
| 10. | FC Sens (6) | 0–6 | UF Mâconnais (6) | |
| 11. | Dun Sornin Chauffailles Brionnais (9) | 0–1 | ASC Saint-Apollinaire (5) | |
| 12. | Racing Besançon (5) | 2–4 | Jura Sud Foot (4) | |
| 13. | ES Fauverney-Rouvres-Bretenière (7) | 2–2 | FC 4 Rivières 70 (6) | |
| 14. | ASC Plombières-Lès-Dijon (9) | 2–3 | Jura Lacs Foot' (6) | |
| 15. | US Saint-Vit (6) | 0–3 | Jura Dolois Football (5) | |
| 16. | Tilles FC (9) | 1–0 | CCS Val d'Amour Mont-sous-Vaudrey (7) | |
| 17. | Team Montceau Foot (9) | 0–3 | Bresse Jura Foot (7) | |
| 18. | Entente Roche-Novillars (6) | 3–1 | Poligny-Grimont FC (7) | |
| 19. | RC Lons-le-Saunier (6) | 1–1 | Besançon Football (5) | |
| 20. | RC Bresse Sud (8) | 0–2 | AS Quetigny (6) | |
| 21. | US Coteaux de Seille (8) | 0–2 | AS Châtenoy-le-Royal (8) | |
| 22. | US Rigny-sur-Arroux (9) | 0–4 | FC Champagnole (6) | |
| 23. | FC Montfaucon-Morre-Gennes-La Vèze (7) | 1–4 | AS Audincourt (6) | |
| 24. | FC Morteau-Montlebon (5) | 2–0 | FC Valdahon-Vercel (5) | |
| 25. | US Châtenois-les-Forges (7) | 2–2 | US Les Écorces (7) | |
| 26. | JS Lure (7) | 0–0 | ASM Belfort (4) | |
| 27. | SG Héricourt (8) | 0–5 | FCC La Joux (7) | |
| 28. | FC Noidanais (7) | 1–2 | FC Grandvillars (5) | |
| 29. | US Pont-de-Roide (6) | 4–0 | AS Ornans (6) | |
| 30. | CA Pontarlier (5) | 2–0 | AS Belfort Sud (6) | |
| 31. | FC L'Isle-sur-le-Doubs (8) | 1–3 | AS Levier (6) | |
| 32. | AS Méziré-Fesches-le-Châtel (8) | 0–0 | ES Pays Maîchois (8) |
These matches were played on 16 and 17 October 2021.[14]
| 1. | US Pont-de-Roide (6) | 1–1 | Entente Roche-Novillars (6) | |
| 2. | Tilles FC (9) | 1–2 | AS Levier (6) | |
| 3. | FC Morteau-Montlebon (5) | 3–1 | CA Pontarlier (5) | |
| 4. | Jura Lacs Foot (6) | 0–0 | ASM Belfort (4) | |
| 5. | Bresse Jura Foot (7) | 3–0 | US Les Écorces (7) | |
| 6. | AS Audincourt (6) | 1–5 | Jura Sud Foot (4) | |
| 7. | FCC La Joux (7) | 1–1 | FC Champagnole (6) | |
| 8. | ES Pays Maîchois (8) | 0–2 | FC Grandvillars (5) | |
| 9. | Is-Selongey Football (5) | 0–0 | ASC Saint-Apollinaire (5) | |
| 10. | Union Cosnoise Sportive (6) | 3–2 | UF Mâconnais (6) | |
| 11. | AS Châtenoy-le-Royal (8) | 1–1 | FR Saint Marcel (7) | |
| 12. | AS Quetigny (6) | 2–2 | RC Lons-le-Saunier (6) | |
| 13. | Louhans-Cuiseaux FC (4) | 5–2 | Paron FC (5) | |
| 14. | UF La Machine (8) | 1–2 | US La Charité (6) | |
| 15. | US Dionysienne (10) | 0–7 | Jura Dolois Football (5) | |
| 16. | FC Chalon (6) | 1–2 | ES Fauverney-Rouvres-Bretenière (7) |
| 1. | Jura Sud Foot (4) | 1–0 | FC Grandvillars (5) | |
| 2. | FC Champagnole (6) | 2–4 | FC Morteau-Montlebon (5) | |
| 3. | ES Fauverney-Rouvres-Bretenière (7) | 0–1 | Jura Dolois Football (5) | |
| 4. | FR Saint Marcel (7) | 1–1 | Louhans-Cuiseaux FC (4) | |
| 5. | ASC Saint-Apollinaire (5) | 2–1 | US La Charité (6) | |
| 6. | Jura Lacs Foot (6) | 1–2 | Bresse Jura Foot (7) | |
| 7. | AS Levier (6) | 1–5 | Union Cosnoise Sportive (6) | |
| 8. | Entente Roche-Novillars (6) | 1–2 | RC Lons-le-Saunier (6) |