| Mode: | Women's Basketball |
| Year: | 2021–22 |
| Prev Year: | 2020–21 |
| Next Year: | 2022–23 |
| Team: | Chicago State Cougars |
| Conference: | Western Athletic Conference |
| Short Conf: | WAC |
| Record: | 4–23 |
| Conf Record: | 3–15 |
| Head Coach: | Tiffany Sardin |
| Hc Year: | 2nd |
| Asst Coach1: | Nan Moore |
| Asst Coach2: | Tiffany Conner |
| Asst Coach3: | Diana Martinez |
| Stadium: | Jones Convocation Center (Capacity: 7,000) |
The 2021–22 Chicago State Cougars women's basketball team will represent Chicago State University in the 2021–22 NCAA Division I women's basketball season. They are led by second-year head coach Tiffany Sardin. The Cougars play their home games at the Emil and Patricia Jones Convocation Center, located in Chicago.
|-!colspan=9 style=|Non-conference regular season|-!colspan=9 style=|WAC conference season