| Mode: | Basketball |
| Year: | 2021–22 |
| Team: | Cal State Northridge Matadors |
| Conference: | Big West Conference |
| Short Conf: | Big West |
| Record: | 7–23 |
| Conf Record: | 3–13 |
| Hc Year: | Interim |
| Asst Coach1: | Terry Johnson |
| Asst Coach2: | Chris Tifft |
| Asst Coach3: | Brandon Billups |
The 2021–22 Cal State Northridge Matadors men's basketball team represented California State University, Northridge in the 2021–22 NCAA Division I men's basketball season. The Matadors, led by interim head coach Trent Johnson, played their home games at the Matadome in Northridge, California as members of the Big West Conference.
In a season limited due to the ongoing COVID-19 pandemic, the Matadors finished the 2020–21 season 9–13, 5–9 in Big West play to finish in eighth place. They lost to Long Beach State in the first round of the Big West tournament.
|-!colspan=12 style=| Non-conference regular season|-!colspan=9 style=| Big West regular season|-!colspan=12 style=| Big West tournament|-Source[1]