| Club: | Cagliari |
| Season: | 2021–22 |
| Ownertitle: | Owner |
| Owner: | Tommaso Giulini |
| Chrtitle: | President |
| Chairman: | Tommaso Giulini |
| Mgrtitle: | Head coach |
| Manager: | Leonardo Semplici (until 14 September) Walter Mazzarri (from 15 September to 2 May) Alessandro Agostini (caretaker, from 2 May) |
| Stadium: | Unipol Domus |
| League: | Serie A |
| League Result: | 18th (relegated) |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| League Topscorer: | João Pedro (13) |
| Season Topscorer: | João Pedro (13) |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 102nd season in the existence of Cagliari Calcio and the club's sixth consecutive season in the top flight of Italian football. In addition to the domestic league, Cagliari participated in this season's edition of the Coppa Italia.
| Player | Moving from | Fee | |||
|---|---|---|---|---|---|
 Boris Radunović | Atalanta | €0.3M | |||
 Giorgio Altare | Genoa | €0.175M | |||
| Paolo Faragò | Bologna | Loan return | |||
| Gabriele Zappa | Pescara | €3.5M | |||
| Martín Cáceres | Fiorentina | Free | |||
| Riccardo Ladinetti | Olbia | Loan return | |||
| Christian Oliva | Valencia | Loan return | |||
 Răzvan Marin | Ajax | €10M | |||
 Keita Baldé | Monaco | €8M | |||
 Damir Ceter | Pescara | Loan return | |||
 Diego Farias | Spezia | Loan return |
| Player | Moving from | Fee | Notes | |||
|---|---|---|---|---|---|---|
| Raoul Bellanova | Bordeaux | N/A | On loan until June 2022 | |||
| Dalbert | Internazionale | N/A | On loan until June 2022 | |||
| Alberto Grassi | Parma | N/A | On loan until June 2022 | |||
| Kevin Strootman | Marseille | N/A | On loan until June 2022 | |||
| Matteo Lovato | Atalanta | N/A | On loan until June 2022 |
| Player | Moving to | Fee | |||
|---|---|---|---|---|---|
| Arturo Calabresi | Bologna | Loan ended | |||
 Ragnar Klavan | Paide Linnameeskond | Free | |||
| Simone Pinna | Olbia | Free | |||
| Daniele Rugani | Juventus | Loan ended | |||
 Kwadwo Asamoah | Free | ||||
| Alfred Duncan | Fiorentina | Loan ended | |||
 Radja Nainggolan | Internazionale | Loan ended | |||
| Kiril Despodov | Ludogorets Razgrad | €2M | |||
| Riccardo Sottil | Fiorentina | Loan ended | |||
| Filip Bradarić | Al-Ahli | €2.7M | |||
| Diego Godín | Atlético Mineiro | Free |
| Player | Moving to | Fee | Notes | |||
|---|---|---|---|---|---|---|
| Guglielmo Vicario | Empoli | N/A | On loan until June 2022 | |||
| Alessandro Tripaldelli | SPAL | N/A | On loan until June 2022 | |||
| Senna Miangué | Cercle Brugge | N/A | On loan until June 2022 | |||
 Mattéo Tramoni | Brescia | N/A | On loan until June 2022 | |||
| Federico Marigosu | Grosseto | N/A | On loan until June 2022 | |||
| Roberto Biancu | Olbia | N/A | On loan until June 2022 | |||
| Fabrizio Caligara | Ascoli | N/A | On loan until June 2022 | |||
| Alberto Cerri | Como | N/A | On loan until June 2022 | |||
| Zito Luvumbo | Como | N/A | On loan until June 2022 | |||
 Giovanni Simeone | Hellas Verona | N/A | On loan until June 2022 | |||
| Luca Gagliano | Avellino | N/A | On loan until June 2022 |
See main article: 2021–22 Serie A.
The league fixtures were announced on 14 July 2021.[1]
See main article: 2021–22 Coppa Italia.
|-! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Goalkeepers
|-! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Defenders|-! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Midfielders|-! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Forwards|-! colspan=14 style="background:#000080; color:#FF0000; text-align:center| Players transferred out during the season