| Club: | CFR Cluj |
| Season: | 2021–22 |
| Owner: | Ioan Varga |
| Manager: | Marius Șumudică (until 28 August)[1] Dan Petrescu (from 31 August) |
| Stadium: | Stadionul Dr. Constantin Rădulescu |
| League: | Liga I |
| League Result: | 1st |
| Cup1: | Cupa României |
| Cup1 Result: | Round of 32 |
| Cup2: | Supercupa României |
| Cup2 Result: | Runners-up |
| Cup3: | UEFA Champions League |
| Cup3 Result: | Third qualifying round |
| Cup4: | UEFA Europa League |
| Cup4 Result: | Play-off round |
| Cup5: | UEFA Europa Conference League |
| Cup5 Result: | Group stage |
| Leftarm1: | 840F1E |
| Leftarm2: | FFFFFF |
| Body1: | 840F1E |
| Body2: | FFFFFF |
| Rightarm1: | 840F1E |
| Rightarm2: | FFFFFF |
| Shorts1: | 840F1E |
| Shorts2: | FFFFFF |
| Socks1: | 840F1E |
| Socks2: | FFFFFF |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was Fotbal Club CFR 1907 Cluj's 26th consecutive season in the Liga I and 114th year in existence as a football club. In addition to the domestic league, CFR Cluj participated in this season's editions of the Cupa României, the Supercupa României, the UEFA Champions League, the UEFA Europa League and the UEFA Europa Conference League.
Source: [2]
See main article: 2021 Supercupa României.
CFR Cluj, as Liga I winners in the previous season, played against Universitatea Craiova in the 2021 Supercupa României, who themselves won the Cupa României.
See main article: 2021–22 Liga I.
See main article: 2021–22 Cupa României.
See main article: 2021–22 UEFA Champions League.
See main article: 2021–22 UEFA Champions League qualifying phase and play-off round.
See main article: 2021–22 UEFA Europa League.
See main article: 2021–22 UEFA Europa League qualifying phase and play-off round.
See main article: 2021–22 UEFA Europa Conference League.
The draw for the group stage was held on 27 August 2021, 13:30 CEST (14:30 TRT), in Istanbul, Turkey.[3]