| 2021–22 CEV Women's Challenge Cup | |
| League: | CEV Women's Challenge Cup |
| Sport: | Volleyball |
| Duration: | November 2021 – 23 March 2022 |
| No Of Teams: | 44 |
| Finals Champ: |  Scandicci |
| Finals Runner-Up: |  La Laguna |
| Seasonslistnames: | CEV Women's Challenge Cup |
| Prevseason Link: | 2020–21 CEV Women's Challenge Cup |
| Prevseason Year: | 2020–21 |
| Nextseason Link: | 2022–23 CEV Women's Challenge Cup |
| Nextseason Year: | 2022–23 |
The 2021–22 CEV Women's Challenge Cup was the 41st edition of the European Challenge Cup volleyball club tournament, the former "CEV Cup".
The tournament is played on a knockout format, with 32 teams participating. Initially 24 teams play a qualification round with the 12 winners advancing to the main phase. On 29 June 2018, a drawing of lots in Luxembourg City, Luxembourg, determined the team's pairing for each match. Each team plays a home and an away match with result points awarded for each leg (3 points for 3–0 or 3–1 wins, 2 points for 3–2 win, 1 point for 2–3 loss). After two legs, the team with the most result points advances to the next round. In case the teams are tied after two legs, a is played immediately at the completion of the second leg. The Golden Set winner is the team that first obtains 15 points, provided that the points difference between the two teams is at least 2 points (thus, the Golden Set is similar to a tiebreak set in a normal match).[1] [2]
The number of participants on the basis of ranking list for European Cup Competitions:
| Rank | Country | Number of teams | Teams | |
|---|---|---|---|---|
| 1 | ||||
| 2 | ||||
| 5 | ||||
| 6 | ||||
| 7 | ||||
| 8 | ||||
| 9 | ||||
| 11 | ||||
| 12 | ||||
| 14 | ||||
| 15 | ||||
| 16 | ||||
| 17 | ||||
| 17 | ||||
| 20 | ||||
| 20 | ||||
| 23 | ||||
| 25 | ||||
| 25 | ||||
| 25 | ||||
| 25 | ||||
| 25 | ||||
| 25 | 2 | Panathinaikos, Voula | ||
| 25 | ||||
| 25 | ||||
| 25 | ||||
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