| Club: | C.D. Santa Clara |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Rui Miguel Melo Cordeiro |
| Mgrtitle: | Manager |
| Manager: | Daniel Ramos |
| Stadium: | Estádio de São Miguel |
| League: | Primeira Liga |
| League Result: | 10th |
| Cup1: | Taça de Portugal |
| Cup1 Result: | Fourth round |
| Cup2: | Taça da Liga |
| Cup2 Result: | Semi-finals |
| Cup3: | UEFA Europa Conference League |
| Cup3 Result: | Play-off round |
| League Topscorer: | Crysan (7) |
| Season Topscorer: | Crysan (7) |
| Pattern La1: | _santaclara2021h |
| Pattern B1: | _santaclara2021h |
| Pattern Ra1: | _santaclara2021h |
| Leftarm1: | FF0000 |
| Body1: | FF0000 |
| Rightarm1: | FF0000 |
| Shorts1: | FFFFFF |
| Socks1: | FF0000 |
| Pattern La2: | _santaclara2021a |
| Pattern B2: | _santaclara2021a |
| Pattern Ra2: | _santaclara2021a |
| Leftarm2: | 000000 |
| Body2: | DCBE64 |
| Rightarm2: | 000000 |
| Shorts2: | 000000 |
| Socks2: | 000000 |
| Updated: | 6 March 2022 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season is the 101st season in the existence of C.D. Santa Clara and the club's third consecutive season in the top flight of Portuguese football. In addition to the domestic league, Santa Clara will participate in this season's edition of the Taça de Portugal, Taça da Liga, and the UEFA Europa Conference League.
See main article: 2021–22 Primeira Liga.
See main article: 2021–22 Taça de Portugal.
See main article: 2021–22 Taça da Liga.
See main article: 2021–22 UEFA Europa Conference League.
The draw for the second qualifying round was held on 16 June 2021.[1]
The draw for the third qualifying round was held on 19 July 2021.[2]
The draw for the play-off round was held on 2 August 2021.[3]