| Tv: | eyecons.com |
| Duration: | 4 September 2021–27 March 2022 |
| Finals Mvp: | Ids Eussen |
| Finals Champ: | KEMBIT-LIONS |
| Finals Runner-Up: | Sezoens Achilles Bocholt |
| League: | BENE-League |
| No Of Games: | 124 |
| No Of Teams: | 12 (6 team) |
| Pixels: | 180px |
| Playoffs: | Final Four |
| Season: | Regular season |
| Season Champs: | KEMBIT-LIONS |
| Sport: | Handball |
| 2021–22 BENE-League season | |
| Top Scorer: |  Serge Spooren (154) |
| Seasonslist: | BENE-League#Winners |
| Seasonslistnames: | BENE-League |
| Prevseason Year: | 2020–21 |
| Nextseason Year: | 2022–23 |
The BENE-League Handball 2020-21 was the sixth edition of the multi-national handball competition between Belgium and the Netherlands.
KEMBIT-LIONS won for the second time the BENE-League.
| Country | Team | City | Venue |
|---|---|---|---|
| Belgium | Sezoens Achilles Bocholt | Bocholt | Sportcomplex De Damburg |
| HC AtomiX | Haacht | Sporthal Den Dijk | |
| Hubo Initia Hasselt | Hasselt | Sporthal Alverberg | |
| Sporting Pelt | Neerpelt | Dommelhof | |
| Handbal Tongeren | Tongeren | Eburons Dôme | |
| HC Visé BM | Visé | Hall Omnisports de Visé | |
| Netherlands | Green Park Handbal Aalsmeer | Aalsmeer | Sporthal De Bloemhof |
| Herpertz/Bevo HC | Panningen | SportArena De Heuf | |
| JD Techniek/Hurry-Up | Zwartemeer | Succes Holidayparcs Arena | |
| KEMBIT-LIONS | Sittard-Geleen | Stadssporthal Sittard | |
| Quintus | Kwintsheul | Eekhout hal | |
| KRAS/Volendam | Volendam | Sporthal de Opperdam |
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