The 2021–22 season is Anadolu Efes's 42nd season in the existence of the club. The team plays in the Basketball Super League and in the EuroLeague.
| Club: | Anadolu Efes |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Tuncay Özilhan |
| Mgrtitle: | Head coach |
| Manager: | Ergin Ataman |
| Stadium: | Sinan Erdem Dome |
| League Result: | 2nd seed |
| Playoffs Result: | Runners-up |
| League2: | EuroLeague |
| League2 Result: | 6th seed |
| Playoffs2 Result: | Champions |
| Cup1: | Turkish Basketball Cup |
| Cup1 Result: | Champions |
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| H Pattern B: | _anadoluefes2022h |
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| H Pattern S: | _anadoluefes2022h |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
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| Competition | Progress | |
|---|---|---|
| EuroLeague | Champions | |
| Basketball Super League | Runners-up | |
| Turkish Basketball Cup | Champions |
See main article: 2021–22 Basketbol Süper Ligi.
See main article: 2021–22 EuroLeague.