| Club: | Al Masry |
| Season: | 2021–22 |
| Manager: | Moïne Chaâbani (until 29 May) Hossam Hassan (from 30 May) |
| Stadium: | Borg El Arab Stadium |
| League: | Premier League |
| League Result: | 13th |
| Cup1: | Egypt Cup |
| Cup1 Result: | Quarter-finals |
| Cup2: | CAF Confederation Cup |
| Cup2 Result: | Quarter-finals |
| League Topscorer: | Hassan Ali Austin Amutu Mohamed Grendo (5 each) |
| Season Topscorer: | Mohamed Grendo (7) |
| Pattern B1: | _almasry2021h |
| Leftarm1: | FFFFFF |
| Body1: | FFFFFF |
| Rightarm1: | FFFFFF |
| Shorts1: | 048341 |
| Socks1: | FFFFFF |
| Pattern B2: | _almasry2021a |
| Leftarm2: | 048341 |
| Body2: | 048341 |
| Rightarm2: | 048341 |
| Shorts2: | FFFFFF |
| Socks2: | 048341 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 102nd season of Al Masry SC. The team are participating in the Egyptian Premier League and Egypt Cup, the domestic cup.
See main article: 2021–22 Egyptian Premier League.
The league fixtures were announced on 12 October 2021.[1]
See main article: 2021–22 Egypt Cup.
See main article: 2021–22 CAF Confederation Cup.
See main article: 2021–22 CAF Confederation Cup group stage. The draw for the group stage was held on 28 December 2021.[2]
See main article: 2021–22 CAF Confederation Cup knockout stage.