| Club: | Sparta Prague |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Daniel Křetínský |
| Mgrtitle: | Head coach |
| Manager: | Pavel Vrba |
| Stadium: | Stadion Letná |
| League: | Czech First League |
| League Result: | 3rd |
| Cup1: | Czech Cup |
| Cup1 Result: | Runners-up |
| Cup2: | UEFA Champions League |
| Cup2 Result: | Third qualifying round |
| Cup3: | UEFA Europa League |
| Cup3 Result: | Group stage |
| Cup4: | UEFA Europa Conference League |
| Cup4 Result: | Knockout round play-offs |
| League Topscorer: | Adam Hložek (9) |
| Season Topscorer: | Adam Hložek (12) |
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| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was the 128th season in the existence of AC Sparta Prague and the club's 29th consecutive season in the top flight of Czech football. In addition to the domestic league, Sparta Prague participated in this season's editions of the Czech Cup, the UEFA Champions League, the UEFA Europa League, and the UEFA Europa Conference League.
See main article: 2021–22 Czech First League.
See main article: 2021–22 Czech Cup.
See main article: 2021–22 UEFA Champions League.
The draw for the second qualifying round was held on 16 June 2021.[2]
The draw for the third qualifying round was held on 19 July 2021.[3]
See main article: 2021–22 UEFA Europa League.
See main article: 2021–22 UEFA Europa Conference League knockout phase.