| Club: | Perugia |
| Season: | 2021–22 |
| Chrtitle: | President |
| Chairman: | Massimiliano Santopadre |
| Mgrtitle: | Head coach |
| Manager: | Massimiliano Alvini |
| Stadium: | Stadio Renato Curi |
| League: | Serie B |
| League Result: | 8th |
| Cup1: | Coppa Italia |
| Cup1 Result: | First round |
| League Topscorer: | Manuel De Luca (10) |
| Season Topscorer: | Manuel De Luca (10) |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 season was A.C. Perugia Calcio's first season back in second division of the Italian football league, the Serie B, and the 117th as a football club.
See main article: 2021–22 Serie B.
The league fixtures were announced on 24 July 2021.[2]
See main article: 2021–22 Coppa Italia.