| Competition: | 2. Frauen-Bundesliga |
| Season: | 2021–22 |
| Winners: | SV Meppen |
| Promoted: | SV Meppen MSV Duisburg |
| Relegated: | SV Elversberg SV Henstedt-Ulzburg Borussia Bocholt |
| Matches: | 182 |
| Total Goals: | 636 |
| League Topscorer: | Nastassja Lein Ramona Maier (25 goals) |
| Longest Wins: | 5 games Meppen |
| Longest Unbeaten: | 5 games Meppen |
| Longest Winless: | 7 games Wolfsburg II |
| Longest Losses: | 4 games Wolfsburg II |
| Biggest Home Win: | Gütersloh 6–0 Wolfsburg II |
| Biggest Away Win: | Bocholt 1–9 Leipzig |
| Highest Scoring: | Bocholt 1–9 Leipzig |
| Attendancecalc: | 26407 |
| Prevseason: | 2020–21 |
| Nextseason: | 2022–23 |
The 2021–22 2. Frauen-Bundesliga was the 18th season of Germany's second-tier women's football league, and the fourth as a single-division league. The season began on 15 August 2021 and concluded on 5 June 2022. The champions and runners-up will be promoted to the Frauen-Bundesliga, while the bottom three teams will be relegated to the Frauen-Regionalliga.[1]
The fixtures were announced on 23 July 2021.[2]
| Team | Home city | Home ground | Capacity | ||
|---|---|---|---|---|---|
| data-sort-value="Andernach" | 15,220 | ||||
| data-sort-value="Bocholt" | In der Hardt | 1,500 | |||
| data-sort-value="Duisburg" | 31,514 | ||||
| data-sort-value="Elversberg" | 9,970 | ||||
| data-sort-value="Frankfurt" | 5,200 | ||||
| data-sort-value="Gutersloh" | Tönnies-Arena | 4,252 | |||
| data-sort-value="Henstedt-Ulzburg" | Stadion Schäferkampsweg | 1,500 | |||
| data-sort-value="Hoffenheim" | Ensinger-Stadion | 4,000 | |||
| data-sort-value="Ingolstadt" | 11,481 | ||||
| data-sort-value="Leipzig" | Sportanlage Gontardweg | 1,300 | |||
| data-sort-value="Meppen" | 16,500 | ||||
| data-sort-value="Munich" | Sportpark Aschheim | 3,000 | |||
| data-sort-value="Nurnberg" | 7,000 | ||||
| data-sort-value="Wolfsburg" | AOK Stadion | 5,200 |
| Rank | Player | Club | Goals[4] | |
|---|---|---|---|---|
| 1 | Nastassja Lein | 1. FC Nürnberg | 25 | |
| Ramona Maier | FC Ingolstadt | |||
| 3 | Vanessa Fudalla | RB Leipzig | 17 | |
| 4 | Annalena Rieke | FSV Gütersloh | 14 | |
| Julia Schermuly | SG 99 Andernach | |||
| 6 | Alexandra Emmerling | SV Meppen | 13 | |
| Indra Hahn | SV Henstedt-Ulzburg | |||
| Marlene Müller | RB Leipzig | |||
| 9 | Isabella Jaron | SV Meppen | 12 | |
| 10 |  Agnieszka Winczo | SV Meppen | 10 |