| Date: | 2 - 8 March |
| Edition: | 1st |
| Category: | WTA International tournaments |
| Draw: | 32S / 16D |
| Surface: | Hard - Indoors |
| Prize Money: | $250,000 |
| Location: | Lyon, France |
| Venue: | Palais des Sports de Gerland |
| Champs: |  Sofia Kenin |
| Champd: |  Laura Ioana Paar / Julia Wachaczyk |
The 2020 Lyon Open (WTA) (also known as the Open 6ème Sens — Métropole de Lyon for sponsorship reasons) was a women's tennis tournament played on indoor hard courts. It was the first edition of the Lyon Open (WTA) and an International tournament on the 2020 WTA Tour. It took place at the Palais des Sports de Gerland in Lyon, France, from 2 to 8 March 2020.[1]
| Country | Player | Ranking1 | Seed | |
|---|---|---|---|---|
| United States | Sofia Kenin | 5 | 1 | |
 France | Kristina Mladenovic | 39 | 2 | |
| France | Caroline Garcia | 47 | 3 | |
| France | Alizé Cornet | 58 | 4 | |
 Belgium | Alison Van Uytvanck | 62 | 5 | |
| Jil Teichmann | 66 | 6 | ||
 Russian Federation | Daria Kasatkina | 73 | 7 | |
 Slovakia | Viktória Kužmová | 85 | 8 |
The following players received wildcards into the main draw:
The following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
Ekaterina Alexandrova → replaced by Anna-Lena Friedsam
Paula Badosa → replaced by Lesley Pattinama Kerkhove Margarita Gasparyan → replaced by Pauline Parmentier
Barbora Krejčíková → replaced by 
Mandy Minella Anastasia Pavlyuchenkova → replaced by Viktoriya Tomova Kristýna Plíšková → replaced by Tereza Martincová| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Anna-Lena Friedsam | Luxembourg | Mandy Minella | 141 | 1 | ||
 Serbia | Aleksandra Krunić | Katarina Srebotnik | 143 | 2 | ||
 Georgia | Oksana Kalashnikova | Russian Federation | Valeria Savinykh | 181 | 3 | |
| Romania | Andreea Mitu | Romania | Raluca Olaru | 211 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: article and 2020 Lyon Open (WTA) – Singles.
Sofia Kenin def. Anna-Lena Friedsam, 6–2, 4–6, 6–4See main article: article and 2020 Lyon Open (WTA) – Doubles.
Laura Ioana Paar / Julia Wachaczyk def. Lesley Pattinama Kerkhove / Bibiane Schoofs, 7–5, 6–4
