| Champ: |  Adrian Mannarino |
| Runner: |  Aleksandar Vukic |
| Score: | 6–1, 6–3 |
| Type: | singles doubles |
| After Year: | 2022 |
See main article: 2020 Monterrey Challenger.
Alexander Bublik was the defending champion[1] but chose not to defend his title.
Adrian Mannarino won the title after defeating Aleksandar Vukic 6–1, 6–3 in the final.
All seeds receive a bye into the second round.