| Date: | 2–8 March |
| Edition: | 11th |
| Draw: | 48S / 16D |
| Surface: | Hard |
| Location: | Monterrey, Mexico |
| Champs: |  Adrian Mannarino |
| Champd: |  Karol Drzewiecki / Gonçalo Oliveira |
| After Year: | 2022 |
The 2020 Monterrey Challenger was a professional tennis tournament played on hard courts. It was the eleventh edition of the tournament which was part of the 2020 ATP Challenger Tour. It took place in Monterrey, Mexico from 2 to 8 March 2020.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| France | Adrian Mannarino | 42 | 1 | |
 Spain | Feliciano López | 52 | 2 | |
| Spain | Pablo Andújar | 54 | 3 | |
 Lithuania | Ričardas Berankis | 62 | 4 | |
 Argentina | Federico Coria | 104 | 5 | |
| Jason Jung | 119 | 6 | ||
 Italy | Paolo Lorenzi | 121 | 7 | |
| Italy | Federico Gaio | 126 | 8 | |
| Italy | Lorenzo Giustino | 153 | 9 | |
 Canada | Steven Diez | 159 | 10 | |
 Serbia | Viktor Troicki | 174 | 11 | |
| Canada | Brayden Schnur | 178 | 12 | |
 Australia | Andrew Harris | 188 | 13 | |
| Canada | Peter Polansky | 189 | 14 | |
| Australia | Bernard Tomic | 201 | 15 | |
| Ernesto Escobedo | 202 | 16 |
The following players received wildcards into the singles main draw:
Milledge Cossu
Alex Hernández Adrian Mannarino
Shintaro Mochizuki Luis PatiñoThe following players received entry from the qualifying draw:
See main article: 2020 Monterrey Challenger – Singles.
Adrian Mannarino def. Aleksandar Vukic 6–1, 6–3.See main article: 2020 Monterrey Challenger – Doubles.
Karol Drzewiecki / Gonçalo Oliveira def. 
Orlando Luz / Rafael Matos 6–7(5–7), 6–4, [11–9].