| Competition: | Divizia Națională |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Sheriff |
| Continentalcup2: | Conference League |
| Continentalcup2 Qualifiers: | Sf. Gheorghe Petrocub Milsami |
| Matches: | 180 |
| Total Goals: | 562 |
| League Topscorer: | Frank Castañeda (28 goals) |
| Biggest Home Win: | |
| Biggest Away Win: | |
| Highest Scoring: | |
| Longest Wins: | 15 matches Sheriff |
| Longest Unbeaten: | 24 matches Petrocub |
| Longest Winless: | 19 matches Codru |
| Longest Losses: | 14 matches Codru |
| Prevseason: | 2019 |
| Nextseason: | 2021–22 |
| Season: | 2020–21 |
| Winners: | Sheriff |
| Best Goalkeeper: | Cristian Avram (15 clean sheets) |
| Relegated: | Buiucani |
The 2020–21 Moldovan National Division (Romanian; Moldavian; Moldovan: Divizia Națională) was the 30th season of top-tier football in Moldova. The season started on 3 July 2020 and ended on 26 May 2021. Sheriff Tiraspol were the defending champions. The winners of the league this season earned a spot in the first qualifying round of the 2021–22 UEFA Champions League, and the second, third and fourth placed clubs earned a place in the first qualifying round of the 2021–22 UEFA Europa Conference League.[1]
A total of 10 teams competing in the league. These include 8 teams from the 2019 season and two promoted teams from the "A" Division: Florești and Dacia Buiucani, both making their debut in the top flight.
| Team | Outgoing manager | Manner of departure | Date of vacancy | Position in table | Replaced by | Date of appointment | |
|---|---|---|---|---|---|---|---|
| Zimbru |  Veaceslav Sofroni | End of caretaker spell | 11 December 2019 | Pre-season |  Sandro Pochesci | 11 December 2019[2] | |
| Codru | Valeriu Andronic | Signed by Moldova U15/U16 | 24 December 2019[3] | Simeon Bulgaru | 23 January 2020[4] | ||
| Milsami | Veaceslav Rusnac | Signed by Kyzylzhar | 9 January 2020[5] | Serghei Dubrovin | 11 March 2020[6] | ||
| Speranța | Cristian Efros | Resigned | 1 February 2020[7] | Iurie Osipenco | 4 February 2020[8] | ||
| Florești | Oleg Șișchin | Demoted to assistant coach | 6 February 2020 | Iurie Groșev | 6 February 2020[9] | ||
| Zimbru | Sandro Pochesci | Resigned | 7 February 2020 | Giovanni Scanu | 7 February 2020[10] | ||
| Zimbru | Giovanni Scanu | Released | 4 March 2020[11] | Vlad Goian | 10 June 2020[12] | ||
| Codru | Simeon Bulgaru | Resigned | 2 June 2020[13] | Sergiu Chirilov | 4 July 2020[14] | ||
| Zimbru | Vlad Goian | Promoted to academy technical director | 16 October 2020 | 9th | Simeon Bulgaru (interim) | 16 October 2020[15] | |
| Sheriff | Zoran Zekić | Resigned | 21 October 2020 | 1st | Victor Mihailov (interim) | 21 October 2020[16] | |
| Victor Mihailov | End of caretaker spell | 14 January 2021 | 1st |  Yuriy Vernydub | 14 January 2021[17] | ||
| Zimbru | Simeon Bulgaru | Resigned | 17 January 2021[18] | 9th | Vlad Goian | 18 January 2021[19] | |
| Codru | Sergiu Chirilov | Released | 18 January 2021 | 10th | Alexei Savinov | 18 January 2021[20] | |
| Speranța | Iurie Osipenco | Released | 24 February 2021 | 7th | Volodymyr Prokopynenko | 24 February 2021[21] |
Teams will play each other four times (twice at home, twice away).
The following table represents the teams game results in each round.[22]
| W #FFFFCC;" | D #FFCCCC;" | L --> | Team | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Codru Lozova | L | L | L | L | L | L | L | L | L | D | D | L | L | L | L | L | L | L | D | W | L | L | L | L | L | L | L | L | L | L | L | L | L | L | W | L | |||
| Dacia Buiucani | W | D | L | W | L | W | L | L | L | W | L | W | L | D | W | D | L | D | W | D | D | D | L | W | W | L | L | D | L | W | L | L | W | W | W | D | |||
| Dinamo-Auto | W | L | W | W | L | L | D | L | W | W | D | L | D | D | L | D | D | W | W | D | D | W | L | L | W | D | W | L | D | L | D | L | L | D | W | W | |||
| Florești | L | W | L | L | D | L | L | W | L | L | D | L | W | D | L | L | W | L | L | L | L | D | D | L | L | L | W | W | L | L | W | W | L | L | W | L | |||
| Milsami Orhei | D | D | W | L | L | W | W | W | W | W | W | W | D | L | W | W | D | W | L | D | W | W | L | W | W | D | W | D | W | W | W | L | W | W | L | W | |||
| Petrocub Hîncești | D | W | W | W | W | W | W | L | W | L | D | W | W | D | W | W | W | W | W | D | W | W | W | W | W | D | W | D | D | W | W | W | W | W | L | D | |||
| W | L | W | W | W | W | L | W | W | D | W | D | D | W | L | W | W | D | L | W | L | L | W | W | L | W | W | W | L | W | L | W | W | L | L | W | ||||
| Sheriff Tiraspol | W | W | W | W | W | W | W | W | W | W | W | W | W | W | W | L | D | W | W | W | W | W | W | W | W | D | W | W | W | W | W | W | W | W | W | D | |||
| L | D | L | L | D | L | W | W | L | L | W | L | D | D | L | D | W | L | L | D | L | L | D | L | L | L | L | L | W | L | D | L | L | L | L | L | ||||
| Zimbru Chișinău | L | D | L | L | W | L | D | L | L | L | L | L | L | W | L | D | L | L | L | D | L | L | W | L | L | L | D | W | W | L | L | W | L | D | L | D |
| Rank | Player | Club | Clean sheets[24] |
|---|---|---|---|
| 1 | Cristian Avram | Petrocub | 15 |
| 2 | Emil Tîmbur | Milsami | 14 |
| 3 | Dumitru Coval | Buiucani | 12 |
| 4 |  Dušan Marković | Sheriff | 10 |
| Zvonimir Mikulić | Sheriff | ||
| 6 | Dumitru Celeadnic | Sheriff | 9 |
| 7 | Victor Străistari | Dinamo-Auto | 6 |
| Nicolai Calancea | Sf. Gheorghe | ||
| 9 | Vladislav Liharev | Florești | 5 |
| 10 | Mickaël Meira | Petrocub | 4 |
| Anatol Chirinciuc | Speranța |
| Player | Home | Away | Result | Date | |
|---|---|---|---|---|---|
| | Petrocub | 7–0 | |||
 | Sheriff | 6–0 | |||
| | Dinamo-Auto | 0–5 | |||
| | Sheriff | 5–0 | |||
| | Petrocub | 1–9 | |||
| | Milsami | 7–2 | |||
 | Dinamo-Auto | 3–0 | |||
 | Sheriff | 0–10 | |||
 | Sheriff | 0–6 | |||
 | Sheriff | 0–7 | |||
 | Sf. Gheorghe | 0–4 |
