| Champ: |  Yui Kamiji |
| Runner: | Momoko Ohtani |
| Score: | 6–2, 6–1 |
See main article: 2020 French Open.
Yui Kamiji defeated Momoko Ohtani in the final, 6–2, 6–1 to win the women's singles wheelchair tennis title at the 2020 French Open.
Diede de Groot was the defending champion,[1] but was defeated by Ohtani in the semifinals. As of the 2024 Wimbledon Championships, this marks de Groot's most recent loss at a grand slam.