See main article: 2020 Abierto Mexicano Telcel.
Nick Kyrgios was the defending champion, but retired from his first round match against Ugo Humbert due to a wrist injury.[1]
Rafael Nadal won the title, defeating Taylor Fritz in the final, 6–3, 6–2. This was the third time that Nadal won the Acapulco Open, and the first time on hard court.