| Competition: | Uganda Premier League |
| Season: | 2020–21 |
| Continentalcup1: | Champions League |
| Continentalcup2: | Confederation Cup |
| Matches: | 213 |
| Total Goals: | 602 |
| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 Uganda Premier League was the 53rd season of the Uganda Premier League, the top-tier football league in Uganda. The season ended prematurely due to a 42-day lockdown as a result of the COVID-19 pandemic with only four rounds to play.[1] FUFA announced Express FC the winners in July 2021 under league regulations that allow a winner to be declared if the league is more than 75% complete.[2] Because the cup was cancelled during the semi-final stage, runners-up URA were selected to represent Uganda in the Confederation Cup.[3]
MYDA and Kitara were already statistically relegated by the time the league was suspended, while Kyetume FC were relegated when the league ended early.