| Club: | OFI Crete F.C. |
| Season: | 2020–21 |
| Ownertitle: | Owner |
| Owner: | Michael Bousis |
| Chrtitle: | President |
| Chairman: | Michael Bousis |
| Mgrtitle: | Head coach |
| Manager: | Georgios Simos Nikos Nioplias |
| Stadium: | Theodoros Vardinogiannis Stadium |
| League: | Super League 1 |
| League Result: | 12th |
| Cup1: | Greek Cup |
| Cup1 Result: | Sixth round |
| Cup2: | Europa League |
| Cup2 Result: | Second qualifying round |
| League Topscorer: | Fabio Sturgeon (5) |
| Season Topscorer: | Fabio Sturgeon Adrián Sardinero (5) |
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| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 OFI Crete F.C. season was the club's 96th season in existence and the third consecutive season in the top flight of Greek football. In addition to the domestic league, OFI participated in this season's editions of the Greek Football Cup and the UEFA Europa League. The season covered the period from 20 July 2020 to 30 June 2021.
| scope=col | Player | Transferred from | scope=col; style="width: 65px;" | Fee | scope=col | Date | scope=col | Source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 15 | TBD |
| scope=col | Player | Transferred to | scope=col; style="width: 65px;" | Fee | scope=col | Date | scope=col | Source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 15 | TBD |
See main article: 2020–21 Super League Greece.
See main article: 2020–21 Greek Football Cup.
See main article: 2020–21 UEFA Europa League.
See main article: 2020–21 UEFA Europa League qualifying phase and play-off round (Main Path).