| Competition: | Iran Football's 2nd Division |
| Season: | 2020–21 |
| Winners: | Mes Shahr-e Babak |
| Promoted: | Mes Shahr-e Babak Shahrdari Hamedan Vista Toorbin |
| Relegated: | Naft Omidiyeh Naft va Gaz Gachsaran Sardar Bukan Avalan Kamyaran |
| Matches: | 366 |
| Total Goals: | 745 |
| League Topscorer: | Nima Eskandarzadeh (11)[1] |
| Biggest Home Win: | Shahid Ghandi Yazd 10-1 Sardar Bukan |
| Biggest Away Win: | Sardar Bukan 0-7 Shahin Bandar Ameri |
| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 Iran Football's 2nd Division season was the 20th under 2nd Division since its establishment in the current format in 2001. The season featured 21 teams from the 2nd Division 2019–20, three new team relegated from the 2019–20 Azadegan League: Elmoadab Tabriz F.C., Sepidrood Rasht S.C., Nirooye Zamini F.C., and four new teams promoted from the 3rd Division 2019–20: Shahin Bandar Ameri, Mohtasham Tabriz, Vista Toorbin, Oghab Tehran F.C.[2]
These changes has been applied before the season:
| Team | Replaced Team | |
|---|---|---|
| Kheibar Khorramabad | Spad Tehran | |
| Caspian Qazvin | Shams Azar Qazvin |
source=[3] Vista Toorbin Tehran won 3-3 on aggregate (on away goals) and promoted to 2021-22 Azadegan League.