| Club: | Sampdoria |
| Season: | 2020–21 |
| Chrtitle: | Chairman |
| Chairman: | Massimo Ferrero |
| Mgrtitle: | Head coach |
| Manager: | Claudio Ranieri |
| Stadium: | Stadio Luigi Ferraris |
| League: | Serie A |
| League Result: | 9th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Fourth round |
| League Topscorer: | Fabio Quagliarella (13) |
| Season Topscorer: | Fabio Quagliarella (13) |
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| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 season was the 75th season in existence of Unione Calcio Sampdoria and the club's ninth consecutive season in the top flight of Italian football. In addition to the domestic league, Sampdoria participated in this season's edition of the Coppa Italia. The season covered the period from 3 August 2020 to 30 June 2021.
See main article: 2020–21 Serie A.
The league fixtures were announced on 2 September 2020.[2]
See main article: 2020–21 Coppa Italia.
|-! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers|-! colspan=14 style=background:#dcdcdc; text-align:center| Defenders|-! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders|-! colspan=14 style=background:#dcdcdc; text-align:center| Forwards|-! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season
| width=15 | width=15 | width=15 | width=15 | width=145 | Name | width=120 | Serie A | width=120 | Coppa Italia | width=120 | Total | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 27 | FW |  | Fabio Quagliarella | 4 | 0 | 4 | ||||||||
| 2 | 3 | DF | | Tommaso Augello | 1 | 0 | 1 | ||||||||
| 15 | DF | Omar Colley | 1 | 0 | 1 | ||||||||||
| 8 | MF | | Valerio Verre | 1 | 0 | 1 | |||||||||
| 14 | MF |  | Jakub Jankto | 1 | 0 | 1 | |||||||||
| 18 | MF |  | Morten Thorsby | 1 | 0 | 1 | |||||||||
| 20 | FW | | Antonino La Gumina | 0 | 1 | 1 | |||||||||
| 38 | MF | Mikkel Damsgaard | 1 | 0 | 1 | ||||||||||
| Totals | 10 | 1 | 11 | ||||||||||||