| Club: | TSG 1899 Hoffenheim |
| Season: | 2020–21 |
| Chrtitle: | President |
| Chairman: | Peter Hofmann |
| Mgrtitle: | Head coach |
| Manager: | Sebastian Hoeneß |
| Stadium: | PreZero Arena |
| League: | Bundesliga |
| League Result: | 11th |
| Cup1: | DFB-Pokal |
| Cup1 Result: | Second round |
| Cup2: | UEFA Europa League |
| Cup2 Result: | Round of 32 |
| League Topscorer: | Andrej Kramarić (20) |
| Season Topscorer: | Andrej Kramarić (25) |
| Highest Attendance: | 6,030 vs Bayern Munich and Borussia Dortmund |
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| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 season was the 122nd season in the existence of TSG 1899 Hoffenheim and the club's 13th consecutive season in the top flight of German football. In addition to the domestic league, TSG 1899 Hoffenheim participated in this season's editions of the DFB-Pokal and in the UEFA Europa League. The season covered the period from 1 July 2020 to 30 June 2021. On 27 September 2020, on matchday 2 of Bundesliga season, Hoffenhiem ended Bayern Munich's 32 match winning run.
| Position | Player | Transferred from | Fee | Date | Source | |
|---|---|---|---|---|---|---|
| 20 | Eintracht Frankfurt | €3,000,000 | [1] | |||
 FK Austria Wien | Undisclosed | [2] | ||||
| 16 | Schalke 04 | Loan | [3] | |||
| 17 | Tottenham Hotspur | Loan | [4] | |||
| 28 | Bayern Munich | Loan | [5] | |||
| 33 |  Rennes | €500,000 | [6] |
| Position | Player | Transferred to | Fee | Date | Source | ||
|---|---|---|---|---|---|---|---|
| 24 | FC Utrecht | Loan | |||||
| 13 | Werder Bremen | €7,000,000 | [7] | ||||
| VfB Stuttgart | €4,000,000 | [8] | |||||
| 28 | Hannover 96 | Free | |||||
| 17 | Eintracht Frankfurt | €3,000,000 | |||||
| 31 |  Internacional | Loan | [9] | ||||
| Moreirense | Undisclosed | [10] | |||||
| 41 | ADO Den Haag | Loan | [11] | ||||
| 33 |  Standard Liège | Loan | [12] | ||||
| 26 | Jahn Regensburg | Loan | [13] | ||||
| 7 | Anderlecht | Loan | [14] |
See main article: 2020–21 Bundesliga.
The league fixtures were announced on 7 August 2020.[15]
See main article: 2020–21 DFB-Pokal.
See main article: 2020–21 UEFA Europa League.
The group stage draw was held on 2 October 2020.[16]
See main article: 2020–21 UEFA Europa League knockout phase.
The draw for the round of 32 was held on 14 December 2020.[17]
|-! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers|-! colspan=14 style=background:#dcdcdc; text-align:center| Defenders|-! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders|-! colspan=14 style=background:#dcdcdc; text-align:center| Forwards|-! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season|-
| width=10 | width=10 | width=10 | width=200 | Player | width=100 | Bundesliga | width=100 | DFB-Pokal | width=120 | Europa League | width=100 | Total | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 27 | MF | Andrej Kramarić | 20 | 3 | 2 | 25 | ||||||||
| 2 | 10 | FW |  Mu'nas Dabbur | 4 | 0 | 6 | 10 | ||||||||
| 3 | 9 | FW | Ihlas Bebou | 9 | 0 | 0 | 9 | ||||||||
| 14 | MF | Christoph Baumgartner | 6 | 0 | 3 | 9 | |||||||||
| 5 | 11 | MF | Florian Grillitsch | 2 | 0 | 2 | 4 | ||||||||
| 23 | FW |  Sargis Adamyan | 2 | 0 | 2 | 4 | |||||||||
| 7 | 17 | DF | Ryan Sessegnon | 2 | 0 | 0 | 2 | ||||||||
| 25 | DF |  Kevin Akpoguma | 1 | 1 | 0 | 2 | |||||||||
| 29 | FW | Robert Skov | 1 | 0 | 1 | 2 | |||||||||
| 35 | FW | Maximilian Beier | 0 | 0 | 2 | 2 | |||||||||
| 11 | 4 | DF |  Ermin Bičakčić | 1 | 0 | 0 | 1 | ||||||||
| 8 | MF | Dennis Geiger | 1 | 0 | 0 | 1 | |||||||||
| 16 | MF | Sebastian Rudy | 1 | 0 | 0 | 1 | |||||||||
| 19 | FW | Ishak Belfodil | 0 | 0 | 1 | 1 | |||||||||
| 20 | MF |  Mijat Gaćinović | 0 | 0 | 1 | 1 | |||||||||
| 33 | FW | Georginio Rutter | 1 | 0 | 0 | 1 | |||||||||
| Own goals | 1 | 0 | 0 | 1 | |||||||||||
| TOTAL | 52 | 4 | 20 | 76 | |||||||||||