| Mode: | Basketball |
| Sex: | none |
| Year: | 2020–21 |
| Prev Year: | 2019–20 |
| Next Year: | 2021–22 |
| Team: | Southern Miss Golden Eagles |
| Conference: | Conference USA |
| Short Conf: | CUSA |
| Division: | West Division |
| Record: | 8–17 |
| Conf Record: | 4–13 |
| Hc Year: | 2nd |
| Asst Coach1: | Kyle Roane |
The 2020–21 Southern Miss Golden Eagles basketball team represented the University of Southern Mississippi during the 2020–21 NCAA Division I men's basketball season. The team was led by second-year head coach Jay Ladner, and played their home games at Reed Green Coliseum in Hattiesburg, Mississippi as members of Conference USA.[1]
|-!colspan=12 style=|Non-conference regular season|-!colspan=12 style=|CUSA regular season|-!colspan=12 style=| Conference USA tournament|-