| Pixels: | 200px |
| Competition: | Premier Soccer League |
| Winners: | Mamelodi Sundowns (11th title) |
| Relegated: | Black Leopards |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Mamelodi Sundowns, AmaZulu FC |
| Continentalcup2: | Confederation Cup |
| Matches: | 240 |
| Total Goals: | 507 |
| League Topscorer: | Bradley Grobler (16 goals) |
| Highest Scoring: | Mamelodi Sundowns 43 AmaZulu FC (22 November 2020) AmaZulu FC 4–3 Bloemfontein Celtic (2 February 2021) |
| Biggest Home Win: | Maritzburg United 51 Chippa United |
| Biggest Away Win: | Cape Town City 15 AmaZulu FC |
| Longest Wins: | (6 games) AmaZulu FC |
| Longest Unbeaten: | (21 games) Mamelodi Sundowns |
| Longest Winless: | (11 games) Chippa United |
| Longest Losses: | (5 games) Black Leopards Maritzburg United TTM |
| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
| Updated: | 5 June 2021 |
| Country: | (16 teams) |
| Dates: | 24 October 2020 – 5 June 2021 |
| Season: | 2020–21 |
The 2020–21 South African Premier Division season (known as the DSTV Premiership for sponsorship reasons) was the 25th season of the Premier Soccer League since its establishment in 1996. Mamelodi Sundowns were the three-time defending champions. This season's winner will qualify for the 2021–22 CAF Champions League along with the second placed team. The 3rd placed team and Nedbank Cup winners qualify for the 2021–22 CAF Confederation Cup.
The following teams have changed division since the 2019–20 season.
Relegated from 2019–20 South African Premier Division
Promoted to 2020–21 South African Premier Division
| Rank | Player | Club | Goals[4] |
|---|---|---|---|
| 1 | Bradley Grobler | SuperSport United | 16 |
| 2 |  Peter Shalulile | Mamelodi Sundowns | 15 |
| 3 | Thabiso Kutumela | Maritzburg United | 12 |
| 4 | Ruzaigh Gamildien | Swallows | 11 |
| 5 | Themba Zwane | Mamelodi Sundowns | 10 |
| 6 | Mduduzi Mdantsane | Cape Town City | 9 |
| Cape Town City | |||
| Bloemfontein Celtic | |||
| 9 | Luvuyo Memela | AmaZulu | 8 |
| Lehlohonolo Majoro | |||
| Lebogang Manyama | Kaizer Chiefs |
See main article: List of Premier Soccer League Hat-tricks.
| Player | For | Against | Result | Date | |
|---|---|---|---|---|---|
| Chippa United | Maritzburg United | 31 (H) | 3 November 2020 | ||
| Mamelodi Sundowns | AmaZulu | 43 (H) | 23 November 2020 | ||
| Kaizer Chiefs | Golden Arrows | 32 (H) | 2 June 2021 |
| No | Player | Club | Clean sheets[5] |
|---|---|---|---|
| 1 |  Dennis Onyango | Mamelodi Sundowns | 15 |
| 2 | Veli Mothwa | AmaZulu | 11 |
| Sifiso Mlungwana | Golden Arrows | ||
| 4 | Washington Arubi | TTM | 10 |
| 5 | Lee Langeveldt | Stellenbosch | 8 |
| Ronwen Williams | SuperSport United | ||
| Peter Leeuwenburgh | Cape Town City | ||
| 8 |  Richard Ofori | Orlando Pirates | 7 |
| Marlon Heugh | TS Galaxy | ||
| 10 |  Daniel Akpeyi | Kaizer Chiefs | 6 |
| Virgil Vries | Swallows |