| Competition: | Macedonian First Football League |
| Season: | 2020–21 |
| Winners: | Shkëndija 4th domestic title |
| Relegated: | Sileks Vardar Belasica |
| Continentalcup1: | Champions League |
| Continentalcup1 Qualifiers: | Shkëndija |
| Continentalcup2: | Europa Conference League |
| Continentalcup2 Qualifiers: | Shkupi Struga Sileks |
| League Topscorer: | Besart Ibraimi (24 goals) |
| Dates: | 8 August 2020 – 16 May 2021 |
| Biggest Home Win: | Sileks 6–0 Vardar (11 April 2021) |
| Biggest Away Win: | Belasica 0–6 Sileks (9 August 2020) |
| Highest Scoring: | Rabotnichki 3–5 Shkëndija (28 April 2021) |
| Matches: | 198 |
| Total Goals: | 485 |
| Longest Wins: | 8 games Shkëndija |
| Longest Unbeaten: | 17 games Shkëndija |
| Longest Winless: | 10 games Belasica Pelister Vardar |
| Longest Losses: | 7 games Belasica |
| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
| Updated: | 16 May 2021 |
The 2020–21 Macedonian First League was the 29th season of the Macedonian First Football League, the highest football league of North Macedonia. It began on 8 August 2020 and ended on 16 May 2021. Vardar were the defending champions, having won their eleventh title in 2019–20 after was season abandoned due to the COVID-19 pandemic. They were the third defending champions to be relegated as defending champions.
Relegated to 2020–21 Second League
|
Relegated to 2021–22 Second League |
| Akademija Pandev Belasica | Borec | Makedonija G.P. | Pelister | Rabotnički Vardar |
|---|---|---|---|---|
| Blagoj Istatov Stadium UEFA | Zoran Paunov Stadium | Gjorče Petrov Stadium | Tumbe Kafe Stadium | Toše Proeski Arena UEFA |
| Capacity: 9,200 | Capacity: 2,000 | Capacity: 3,000 | Capacity: 9,100 | Capacity: 36,460 |
| Renova Shkëndija | Shkupi | Sileks | Struga | |
| Tetovo Stadium | Park Stadium | City Stadium Kratovo | Gradska Plaža Stadium | |
| Capacity: 15,000 | Capacity: 6,000 | Capacity: 4,800 | Capacity: 2,500 | |
Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players may hold more than one non-FIFA nationality.
| Team | Manager | Captain | Kit manufacturer | Shirt sponsor |
|---|---|---|---|---|
| Akademija Pandev |  | |  Sportika SA | Strumka, JOXX, Elenica |
| Belasica | | | Sportika SA | Pinda Shop |
| Borec | | | Legea | Brako |
| Makedonija G.P. | | | Givova | betinasia, Tesla |
| Pelister | | | Legea | SN Broker |
| Rabotnički | | |  Joma | Seavus |
| Renova | | | Jako | Renova |
| Shkëndija |  | | Macron | Ecolog |
| Shkupi | | |  Sunrise | - |
| Sileks | | | Sunrise | - |
| Struga | | | Adidas | Trim & Lum |
| Vardar | | | Hummel | Komiti Skopje |
Every team will play three times against each other team for a total of 33 matches. The first 22 matchdays will consist of a regular double round-robin schedule. The league standings at this point will then be used to determine the games for the last 11 matchdays.
The table lists the positions of teams after each week of matches. In order to preserve chronological evolvements, any postponed matches are not included to the round at which they were originally scheduled, but added to the full round they were played immediately afterwards.
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| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | Besart Ibraimi | Shkëndija | 24 |
| 2 | Dembo Darboe | Shkupi | 16 |
| 3 | Pepi Gorgiev | Sileks | 13 |
| 4 | Fahrudin Gjurgjevikj | Rabotnichki | 12 |
| 5 | Denis Ristov | Sileks | 9 |
| 6 |  Basit Abdul Khalid | Makedonija G.P. | 8 |
| Bobi Bozhinovski | Makedonija G.P. | ||
| Matej Cvetanoski | Vardar & Shkupi | ||
| Ivan Ivanovski | Sileks | ||
| Alen Jasharoski | Renova | ||
| Antonio Kalanoski | Belasica | ||
| Martin Mirčevski | Belasica & Vardar | ||
| Remzifaik Selmani | Renova | ||
| Shefit Shefiti | Renova | ||
| Luka Stankovski | Rabotnichki | ||