| Club: | Karlsruher SC |
| Season: | 2020–21 |
| Chairman: | Ingo Wellenreuther |
| Mgrtitle: | Manager |
| Manager: | Christian Eichner |
| Stadium: | Wildparkstadion |
| League: | 2. Bundesliga |
| League Result: | 6th |
| Cup1: | DFB-Pokal |
| Cup1 Result: | First round |
| League Topscorer: | Philipp Hofmann (13 goals) |
| Season Topscorer: | Philipp Hofmann (13 goals) |
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| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 Karlsruher SC season was the club's 69th season in existence and the club's 2nd consecutive season in the second flight of German football. In addition to the domestic league, Karlsruher SC participated in this season's edition of the DFB-Pokal, being eliminated in the first round. The season covers the period from 1 July 2020 to 30 June 2021.
| scope=col | Player | Transferred from | scope=col; style="width: 65px;" | Fee | scope=col | Date | scope=col | Source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 15 | TBD |
| scope=col | Player | Transferred to | scope=col; style="width: 65px;" | Fee | scope=col | Date | scope=col | Source | ||
|---|---|---|---|---|---|---|---|---|---|---|
| 15 | TBD |
See main article: 2020–21 2. Bundesliga.
The league fixtures were announced on 7 August 2020.[2]
See main article: 2020–21 DFB-Pokal.