| Club: | Genoa |
| Season: | 2020–21 |
| Chrtitle: | Chairman |
| Chairman: | Enrico Preziosi |
| Mgrtitle: | Head coach |
| Manager: | Rolando Maran (until 21 December) Davide Ballardini (from 21 December) |
| Stadium: | Stadio Luigi Ferraris |
| League: | Serie A |
| League Result: | 11th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Round of 16 |
| League Topscorer: | Mattia Destro (11) |
| Season Topscorer: | Gianluca Scamacca (12) |
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| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 Genoa C.F.C. season was the club's 128th season in existence and its 14th consecutive season in the top flight of Italian football. In addition to the domestic league, Genoa participated in the Coppa Italia. The season covered the period from 3 August 2020 to 30 June 2021.
See main article: 2020–21 Serie A.
The league fixtures were announced on 2 September 2020.[2]
See main article: 2020–21 Coppa Italia.
|-! colspan=14 style=background:#dcdcdc; text-align:center| Goalkeepers|-! colspan=14 style=background:#dcdcdc; text-align:center| Defenders|-! colspan=14 style=background:#dcdcdc; text-align:center| Midfielders|-! colspan=14 style=background:#dcdcdc; text-align:center| Forwards|-! colspan=14 style=background:#dcdcdc; text-align:center| Players transferred out during the season
| width=15 | width=15 | width=15 | width=15 | width=145 | Name | width=100 | Serie A | width=100 | Coppa Italia | width=100 | Total | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 9 | FW |  | Gianluca Scamacca | 8 | 4 | 12 | ||||||||
| 2 | 23 | FW | | Mattia Destro | 11 | 0 | 11 | ||||||||
| 3 | 61 | FW |  | Eldor Shomurodov | 8 | 0 | 8 | ||||||||
| 4 | 19 | FW |  | Goran Pandev | 7 | 0 | 7 | ||||||||
| 5 | 77 | DF | | Davide Zappacosta | 4 | 0 | 4 | ||||||||
| 6 | 37 | FW | Marko Pjaca | 3 | 0 | 3 | |||||||||
| 7 | 8 | MF | Lukas Lerager | 1 | 1 | 2 | |||||||||
| 99 | DF | Lennart Czyborra | 1 | 1 | 2 | ||||||||||
| 8 | 47 | MF | Milan Badelj | 1 | 0 | 1 | |||||||||
| 4 | DF | | Domenico Criscito | 1 | 0 | 1 | |||||||||
| 16 | MF | Miha Zajc | 1 | 0 | 1 | ||||||||||
| 24 | MF | | Filippo Melegoni | 0 | 1 | 1 | |||||||||
| 27 | MF | | Stefano Sturaro | 1 | 0 | 1 | |||||||||
| Totals | 47 | 7 | 54 | ||||||||||||