| 2020–21 Cuban National Series | |
| League: | Cuban National Series |
| Sport: | Baseball |
| Duration: | 12 September – 20 January |
| No Of Games: | 75 |
| No Of Teams: | 16 |
| Season: | Regular season |
| Season Champ Name: | Best record |
| Season Champs: | Sancti Spíritus & Granma (48–27) |
| Playoffs: | Postseason |
| Finals Champ: | Granma (3rd title) |
| Finals Runner-Up: | Matanzas |
| Seasonslistnames: | SNB |
| Prevseason Link: | 2019–20 Cuban National Series |
| Prevseason Year: | 2019–20 |
| Nextseason Link: | 2022 Cuban National Series |
| Nextseason Year: | 2022 |
The 2020–21 Cuban National Series was the 60th season of the league.[1] Granma defeated defending champion Matanzas in the series' final round.[2]