The 2020–21 Coupe de France preliminary rounds, Centre-Val de Loire was the qualifying competition to decide which teams from the leagues of the Centre-Val de Loire region of France took part in the main competition from the seventh round.
A total of four teams qualified from the Centre-Val de Loire Preliminary rounds.[1] In 2019–20, Saint-Pryvé Saint-Hilaire FC progressed furthest in the main competition, reaching the round of 32 before losing to Monaco 1–3.[2]
A total of 256 teams entered from the region. The draw required a Preliminary round involving 178 clubs from the district divisions and Régional 3 on 30 August 2020. The 59 clubs from the regional division (other than those Régional 3 clubs already entered) entered at the first round stage on 6 September 2020. The draw for the preliminary, first and second rounds was made on 21 July 2020.[3]
The third round draw, which saw the entry of the Championnat National 3 clubs, was made on 10 September 2020.[4] The fourth round draw, which saw the entry of the Championnat National 2 clubs, was made on 24 September 2020.[5] The fifth round draw, which saw the single Championnat National side from the region enter the competition, was made on 8 October 2020.[6] The sixth round draw was made on 20 October 2020.[7]
These matches were played on 29 and 30 August 2020, with one postponed until 3 September 2020.[8]
| Tie no | Home team (tier) | Score | Away team (tier) | |
|---|---|---|---|---|
| 1. | AS Tréon (12) | 3–2 | RC Bû Abondant (11) | |
| 2. | Amicale Courvilloise (9) | 3–3 | FC Lèves (10) | |
| 3. | CO Cherisy (10) | 7–5 | FJ Champhol (8) | |
| 4. | FC Tremblay-les-Villages (9) | 1–0 | Avenir Ymonville (8) | |
| 5. | US Brezolles (11) | 1–5 | ACSF Dreux (9) | |
| 6. | ES Beauceronne (10) | 2–6 | US Vallée du Loir (9) | |
| 7. | CS Oucques (10) | 7–1 | AS La Bazoche-Gouet (11) | |
| 8. | CA Ouzouer-le-Marché (9) | 2–1 | La Gauloise Foot (11) | |
| 9. | RS Patay (12) | 1–0 | UP Illiers-Combray (9) | |
| 10. | Amicale Gallardon (10) | 3–2 | US Alluyes (11) | |
| 11. | OC Châteaudun (9) | 0–3 | AS Baccon-Huisseau (8) | |
| 12. | FC Lucé Ouest (10) | 0–6 | Dammarie Foot Bois-Gueslin (8) | |
| 13. | AS Nogent-le-Rotrou (13) | 2–5 | FC Beauvoir (10) | |
| 14. | US Pontoise (11) | 3–1 | SA Marboué (10) | |
| 15. | AMSD Chartres (11) | 1–6 | Auneau FC (11) | |
| 16. | CAN Portugais Chartres (10) | 4–1 | Béville SF (11) | |
| 17. | Amicale Sours (9) | 6–1 | CS Angerville-Pussay (9) | |
| 18. | AC Bréhémont (11) | 1–7 | OC Tours (10) | |
| 19. | CS Tourangeau Veigne (11) | 2–4 | AS Villiers-au-Bouin (9) | |
| 20. | US Ports-Nouâtre (11) | 0–3 | US Véronaise (10) | |
| 21. | ES Oésienne (10) | 0–2 | FC Véretz-Azay-Larçay (10) | |
| 22. | AS Fondettes (9) | 1–1 | US Saint-Pierre-des-Corps (9) | |
| 23. | AS Pays de Racan (10) | 3–4 | SC La Croix-en-Touraine (11) | |
| 24. | US Monnaie (9) | 2–2 | AS Chanceaux (9) | |
| 25. | US Saint-Nicolas-de-Bourgueil (12) | 0–2 | US Pernay (11) | |
| 26. | ASPO Tours (11) | 4–3 | FC Gâtine Choisilles (10) | |
| 27. | AS de la Vallée du Lys (12) | 2–4 | AS Villedômer (10) | |
| 28. | Football Choisille Lamembrolle-Mettray (10) | 4–3 | AS Tours Sud (11) | |
| 29. | JS Cormeray (10) | 2–1 | AS Suèvres (10) | |
| 30. | ES Chargé (10) | 4–1 | AS Chailles-Candé 99 (10) | |
| 31. | ASC Turque Blois (11) | 0–1 | ES Villebarou (9) | |
| 32. | US Fougères Ouchamps Feings (11) | 1–2 | ASC Portugais Blois (9) | |
| 33. | AS Nazelles-Négron (11) | 0–6 | Avenir Saint-Amand-Longpré (8) | |
| 34. | AS Cléry-Mareau (11) | 2–2 | CS Lusitanos Beaugency (9) | |
| 35. | US Renaudine (9) | 4–1 | FC Bléré Val de Cher (9) | |
| 36. | Ormes-Saint-Péravy FC (11) | 0–3 | ASL Orchaise (9) | |
| 37. | AG Boigny-Chécy-Mardié (9) | 3–1 | FCO Saint-Jean-de-la-Ruelle (9) | |
| 38. | US Fertesienne (10) | 0–3 | CO BRGM Orléans (11) | |
| 39. | COS Marcilly-en-Villette (10) | 2–2 | US Saint-Cyr-en-Val (11) | |
| 40. | USS Portugais Orléans (10) | 3–1 | Saint-Denis-en-Val FC (11) | |
| 41. | ES Loges et Forêt (9) | 4–1 | CD Espagnol Orléans (10) | |
| 42. | FC Coullons-Cerdon (10) | 1–3 | AS Nouan-Lamotte (9) | |
| 43. | FC Semoy (10) | 1–0 | Jargeau-Saint-Denis FC (10) | |
| 44. | RC Bouzy-Les Bordes (10) | 0–2 | ES Marigny (9) | |
| 45. | FC Vallée de l'Ouanne (9) | 2–4 | US Châlette (10) | |
| 46. | FC Mandorais (10) | 4–1 | EE Pithiviers-le-Veil-Dadonville (11) | |
| 47. | US Turcs Châlette (10) | 0–3 | SC Malesherbes (9) | |
| 48. | ES Nancray-Chambon-Nibelle (9) | 0–1 | Neuville Sports (9) | |
| 49. | US Ousson-sur-Loire (10) | 0–7 | ES Gâtinaise (8) | |
| 50. | FC Martizay Mézières Tournon (9) | 0–6 | AC Parnac Val d'Abloux (9) | |
| 51. | AS Ingrandes (11) | 2–2 | ACS Buzançais (9) | |
| 52. | ES Val de Veude (11) | 2–2 | ES Bourgueil (9) | |
| 53. | FC Berry Touraine (10) | 1–3 | US Yzeures-Preuilly (9) | |
| 54. | US Villedieu-sur-Indre (10) | 1–1 | Loches AC (10) | |
| 55. | JL Val de Creuse (11) | 1–3 | Entente Arpheuilles-Clion-Saulnay (10) | |
| 56. | AF Bouchardais (11) | 1–7 | FC Étoile Verte (9) | |
| 57. | US Montbazon (11) | 4–1 | AS Esvres (10) | |
| 58. | AS Niherne (10) | 0–1 | FC de la Marche Occitane (10) | |
| 59. | US Pouillé-Mareuil (11) | 2–0 | AJS Théséenne (11) | |
| 60. | US Argy (11) | 0–8 | US Gâtines (10) | |
| 61. | AS Chabris (10) | 3–0 | ES Vineuil-Brion (10) | |
| 62. | ES Villefranche-sur-Cher (10) | 1–0 | USC Châtres-Langon-Mennetou (9) | |
| 63. | US Buxeuil (12) | 1–4 | FC Levroux (9) | |
| 64. | AC Villers-les-Ormes (11) | 3–0 | ES Poulaines (9) | |
| 65. | US Pruniers-en-Sologne (9) | 2–0 | FC Portugais Selles-sur-Cher | |
| 66. | AS Les Bordes (11) | 6–2 | Liniez AC (11) | |
| 67. | JS de la Montagne (11) | 0–1 | US Reuilly (9) | |
| 68. | JAS Moulins-sur-Céphons (10) | 1–4 | Saint-Roch City Romorantin (10) | |
| 69. | US Nançay-Neuvy-Vouzeron (10) | 0–4 | US Poilly-Autry (10) | |
| 70. | CS Foëcy (11) | 0–1 | SL Chaillot Vierzon (9) | |
| 71. | US Sainte-Solange (12) | 2–1 | Olympique Mehunois (10) | |
| 72. | USA Lury-Méreau (10) | 0–2 | Olympique Portugais Mehun-sur-Yèvre (9) | |
| 73. | US Briare (11) | 2–3 | FC Verdigny Sancerre (9) | |
| 74. | CS Argentais (11) | 1–6 | AS Salbris (10) | |
| 75. | AS Gien (11) | 0–3 | Bonny-Beaulieu FC (10) | |
| 76. | US Châteaumeillant-Le Châtelet-Culan (10) | 1–7 | SA Issoudun (9) | |
| 77. | US Aigurande (9) | 4–0 | EGC Touvent Châteauroux (9) | |
| 78. | FC Sacierges-Saint-Martin/Saint-Civran/Roussines/Prissac (13) | 0–0 | FC Velles-Arthon-La Pérouille 36 (9) | |
| 79. | La Patriote Ambrault (10) | 8–0 | US Montierchaume (10) | |
| 80. | Étoile Châteauroux (10) | 1–1 | AS Neuvy-Pailloux (10) | |
| 81. | SS Cluis (11) | 0–4 | AS Jeu-les-Bois (11) | |
| 82. | FC Saint-Denis-de-Jouhet/Sarzay (11) | 2–1 | ES Étrechet (10) | |
| 83. | FC Avord (10) | 3–0 | US Saint-Florent-sur-Cher (10) | |
| 84. | Olympique Morthomiers (10) | 0–2 | US Dun-sur-Auron (10) | |
| 85. | ASIE du Cher (10) | 2–5 | SC Châteauneuf-sur-Cher (9) | |
| 86. | ES Justices Bourges (11) | 4–1 | Avenir de la Septaine (10) | |
| 87. | ASC Levet (12) | 1–4 | Avenir Lignières (9) | |
| 88. | ES Vallée Verte (9) | 1–1 | AS Monts (8) | |
| 89. | US La Châtre (8) | 3–1 | ECF Bouzanne Vallée Noire (9) |
These matches were played on 5 and 6 September 2020.[9]
| Tie no | Home team (tier) | Score | Away team (tier) | |
|---|---|---|---|---|
| 1. | Amicale Épernon (8) | 0–1 | FC Drouais (6) | |
| 2. | ACSF Dreux (9) | 0–1 | ES Maintenon-Pierres (8) | |
| 3. | CO Cherisy (10) | 1–1 | AS Baccon-Huisseau (8) | |
| 4. | AS Tréon (12) | 4–0 | Amicale Courvilloise (9) | |
| 5. | ES Nogent-le-Roi (7) | 1–2 | AS Tout Horizon Dreux (8) | |
| 6. | RS Patay (12) | 1–2 | FC Tremblay-les-Villages (9) | |
| 7. | US Vallée du Loir (9) | 5–1 | AS Nogent-le-Rotrou (13) | |
| 8. | Football Choisille Lamembrolle-Mettray (10) | 1–4 | US Portugaise Joué-lès-Tours (7) | |
| 9. | US Pontoise (11) | 2–4 | ||
| 10. | CS Oucques (10) | 5–1 | CA Ouzouer-le-Marché (9) | |
| 11. | Amicale Sours (9) | 1–2 | CS Mainvilliers (7) | |
| 12. | CAN Portugais Chartres (10) | 3–5 | FC Saint-Georges-sur-Eure (6) | |
| 13. | Auneau FC (11) | 0–3 | Dammarie Foot Bois-Gueslin (8) | |
| 14. | Luisant AC (7) | 1–3 | Amicale de Lucé (8) | |
| 15. | SC La Croix-en-Touraine (11) | 1–1 | Racing La Riche-Tours (8) | |
| 16. | OC Tours (10) | 1–1 | CCSP Tours (7) | |
| 17. | US Véronaise (10) | 1–5 | US Chambray-lès-Tours (6) | |
| 18. | ÉB Saint-Cyr-sur-Loire (6) | 4–0 | ES La Ville-aux-Dames (8) | |
| 19. | AS Fondettes (9) | 1–4 | Joué-lès-Tours FCT (7) | |
| 20. | AS Villiers-au-Bouin (9) | 0–2 | ES Vallée Verte (9) | |
| 21. | US Pernay (11) | 0–1 | Langeais Cinq-Mars Foot (8) | |
| 22. | FC Véretz-Azay-Larçay (10) | 1–3 | ASPO Tours (11) | |
| 23. | AS Villedômer (10) | 0–4 | US Monnaie (9) | |
| 24. | ASL Orchaise (9) | 2–1 | US Vendôme (8) | |
| 25. | US Renaudine (9) | 2–1 | AS Chouzy-Onzain (8) | |
| 26. | ASJ La Chaussée-Saint-Victor (7) | 0–0 | US Beaugency Val-de-Loire (7) | |
| 27. | CS Lusitanos Beaugency (9) | 3–1 | US Mer (8) | |
| 28. | JS Cormeray (10) | 0–4 | US Chitenay-Cellettes (8) | |
| 29. | ES Chargé (10) | 0–4 | Vineuil SF (6) | |
| 30. | AFC Blois (8) | 0–0 | AS Contres (6) | |
| 31. | Avenir Saint-Amand-Longpré (8) | 0–0 | ES Villebarou (9) | |
| 32. | ASC Portugais Blois (9) | 1–0 | CA Montrichard (8) | |
| 33. | AS Nouan-Lamotte (9) | 1–0 | CO BRGM Orléans (11) | |
| 34. | USM Olivet (7) | 3–3 | ESCALE Orléans (8) | |
| 35. | US Saint-Cyr-en-Val (11) | 0–4 | SMOC Saint-Jean-de-Braye (8) | |
| 36. | USS Portugais Orléans (10) | 0–9 | FCM Ingré (7) | |
| 37. | ES Marigny (9) | 3–0 | CJF Fleury-les-Aubrais (8) | |
| 38. | AG Boigny-Chécy-Mardié (9) | 1–1 | FC Semoy (10) | |
| 39. | ES Loges et Forêt (9) | 0–2 | ES Chaingy-Saint-Ay (7) | |
| 40. | US Châlette (10) | 1–3 | FC Mandorais (10) | |
| 41. | SC Malesherbes (9) | 4–0 | US Dampierre-en-Burly (8) | |
| 42. | ES Gâtinaise (8) | 2–3 | CA Pithiviers (6) | |
| 43. | Neuville Sports (9) | 1–4 | CSM Sully-sur-Loire (7) | |
| 44. | FC Étoile Verte (9) | 1–2 | Le Richelais (8) | |
| 45. | AS Ingrandes (11) | 1–2 | US Montbazon (11) | |
| 46. | US Yzeures-Preuilly (9) | 5–1 | US Argenton Le Pêchereau (8) | |
| 47. | ES Bourgueil (9) | 2–2 | Saint-Georges Descartes (8) | |
| 48. | AC Parnac Val d'Abloux (9) | 0–1 | US Le Blanc (8) | |
| 49. | US Villedieu-sur-Indre (10) | 0–5 | SC Azay-Cheillé (6) | |
| 50. | Entente Arpheuilles-Clion-Saulnay (10) | 2–1 | FC de la Marche Occitane (10) | |
| 51. | US Gâtines (10) | 3–1 | AS Les Bordes (11) | |
| 52. | FC Levroux (9) | 0–0 | Cher-Sologne Football (8) | |
| 53. | US Pouillé-Mareuil (11) | 3–3 | US Pruniers-en-Sologne (9) | |
| 54. | ES Villefranche-sur-Cher (10) | 1–3 | SC Massay (7) | |
| 55. | AS Chabris (10) | 1–3 | SC Vatan (8) | |
| 56. | US Reuilly (9) | 0–3 | Diables Rouges Selles-Saint-Denis (9) | |
| 57. | Saint-Roch City Romorantin (10) | 0–0 | AC Villers-les-Ormes (11) | |
| 58. | Bonny-Beaulieu FC (10) | 2–1 | US Henrichemont-Menetou-Salon (8) | |
| 59. | US Sainte-Solange (12) | 2–1 | CS Vignoux-sur-Barangeon (8) | |
| 60. | AS Salbris (10) | 1–2 | FC Fussy-Saint-Martin-Vigneux (8) | |
| 61. | AS Saint-Germain-du-Puy (8) | 0–2 | FC Saint-Doulchard (7) | |
| 62. | FC Verdigny Sancerre (9) | 0–0 | SL Chaillot Vierzon (9) | |
| 63. | Olympique Portugais Mehun-sur-Yèvre (9) | 2–1 | US Poilly-Autry (10) | |
| 64. | US Le Poinçonnet (8) | 2–2 | FC Diors (7) | |
| 65. | FC Saint-Denis-de-Jouhet/Sarzay (11) | 0–1 | US La Châtre (8) | |
| 66. | AS Jeu-les-Bois (11) | 1–4 | US Montgivray (8) | |
| 67. | SA Issoudun (9) | 9–0 | La Patriote Ambrault (10) | |
| 68. | AS Neuvy-Pailloux (10) | 2–3 | US Saint-Maur (8) | |
| 69. | FC Velles-Arthon-La Pérouille 36 (9) | 2–0 | US Aigurande (9) | |
| 70. | FC Avord (10) | 0–3 | AS Saint-Amandoise (6) | |
| 71. | ES Trouy (8) | 1–1 | AS Portugais Bourges (6) | |
| 72. | ES Justices Bourges (11) | 1–3 | Avenir Lignières (9) | |
| 73. | US Dun-sur-Auron (10) | 1–0 | ES Moulon Bourges (7) | |
| 74. | SC Châteauneuf-sur-Cher (9) | 0–1 | Gazélec Bourges (8) |
These matches were played on 13 September 2020, with one replayed on 27 September 2020.[10]
| Tie no | Home team (tier) | Score | Away team (tier) | |
|---|---|---|---|---|
| 1. | CS Oucques (10) | 1–4 | AS Tréon (12) | |
| 2. | CO Cherisy (10) | 3–7 | FC Saint-Georges-sur-Eure (6) | |
| 3. | Amicale Gallardon (10) | 1–3 | US Portugaise Joué-lès-Tours (7) | |
| 4. | CS Mainvilliers (7) | 4–1 | AS Tout Horizon Dreux (8) | |
| 5. | FC Mandorais (10) | 1–3 | Dammarie Foot Bois-Gueslin (8) | |
| 6. | CSM Sully-sur-Loire (7) | 1–1 | ES Maintenon-Pierres (8) | |
| 7. | US Vallée du Loir (9) | 1–6 | CA Pithiviers (6) | |
| 8. | Amicale de Lucé (8) | 0–0 | SC Malesherbes (9) | |
| 9. | FC Tremblay-les-Villages (9) | 0–5 | FC Drouais (6) | |
| 10. | OC Tours (10) | 6–2 | Langeais Cinq-Mars Foot (8) | |
| 11. | US Montbazon (11) | 0–2 | ES Vallée Verte (9) | |
| 12. | SC Azay-Cheillé (6) | 1–4 | US Chambray-lès-Tours (6) | |
| 13. | Racing La Riche-Tours (8) | 1–8 | ÉB Saint-Cyr-sur-Loire (6) | |
| 14. | Le Richelais (8) | 0–2 | US Yzeures-Preuilly (9) | |
| 15. | Saint-Georges Descartes (8) | 2–1 | US Monnaie (9) | |
| 16. | ASPO Tours (11) | 6–0 | Entente Arpheuilles-Clion-Saulnay (10) | |
| 17. | US Le Blanc (8) | 0–2 | Joué-lès-Tours FCT (7) | |
| 18. | FC Semoy (10) | 2–2 | USM Olivet (7) | |
| 19. | US Sainte-Solange (12) | 1–3 | FC Saint-Doulchard (7) | |
| 20. | ASC Portugais Blois (9) | 0–2 | SMOC Saint-Jean-de-Braye (8) | |
| 21. | FC Fussy-Saint-Martin-Vigneux (8) | 1–3 | Vineuil SF (6) | |
| 22. | US Renaudine (9) | 0–4 | ES Chaingy-Saint-Ay (7) | |
| 23. | US Chitenay-Cellettes (8) | 2–1 | Avenir Saint-Amand-Longpré (8) | |
| 24. | ES Marigny (9) | 0–1 | FC Verdigny Sancerre (9) | |
| 25. | Bonny-Beaulieu FC (10) | 0–4 | Olympique Portugais Mehun-sur-Yèvre (9) | |
| 26. | AS Nouan-Lamotte (9) | 0–2 | FCM Ingré (7) | |
| 27. | ASL Orchaise (9) | 2–2 | AS Contres (6) | |
| 28. | CS Lusitanos Beaugency (9) | 2–6 | ASJ La Chaussée-Saint-Victor (7) | |
| 29. | Cher-Sologne Football (8) | 2–2 | FC Velles-Arthon-La Pérouille 36 (9) | |
| 30. | US Gâtines (10) | 0–4 | AS Portugais Bourges (6) | |
| 31. | US Montgivray (8) | 0–2 | SC Vatan (8) | |
| 32. | Diables Rouges Selles-Saint-Denis (9) | 3–2 | US Saint-Maur (8) | |
| 33. | SC Massay (7) | 0–0 | US Le Poinçonnet (8) | |
| 34. | Avenir Lignières (9) | 0–0 | Saint-Roch City Romorantin (10) | |
| 35. | Gazélec Bourges (8) | 0–1 | SA Issoudun (9) | |
| 36. | US La Châtre (8) | 1–3 | AS Saint-Amandoise (6) | |
| 37. | US Pouillé-Mareuil (11) | 2–1 | US Dun-sur-Auron (10) |
These matches were played on 19 and 20 September 2020, with one postponed until 30 September 2020 due to awaiting the outcome of the previous round.[11]
| Tie no | Home team (tier) | Score | Away team (tier) | |
|---|---|---|---|---|
| 1. | FC Drouais (6) | 1–1 | FC Ouest Tourangeau (5) | |
| 2. | Diables Rouges Selles-Saint-Denis (9) | 1–5 | AS Portugais Bourges (6) | |
| 3. | SC Vatan (8) | 1–6 | US Châteauneuf-sur-Loire (5) | |
| 4. | ASJ La Chaussée-Saint-Victor (7) | 0–3 | Vierzon FC (5) | |
| 5. | ASL Orchaise (9) | 2–0 | FC Saint-Doulchard (7) | |
| 6. | Saint-Roch City Romorantin (10) | 1–3 | AS Saint-Amandoise (6) | |
| 7. | SA Issoudun (9) | 3–0 | Vineuil SF (6) | |
| 8. | US Yzeures-Preuilly (9) | 2–1 | Cher-Sologne Football (8) | |
| 9. | ASPO Tours (11) | 1–1 | Joué-lès-Tours FCT (7) | |
| 10. | FC Verdigny Sancerre (9) | 0–8 | FC Montlouis (5) | |
| 11. | FC Saint-Jean-le-Blanc (5) | 0–1 | FC Déolois (5) | |
| 12. | US Pouillé-Mareuil (11) | 1–11 | SC Massay (7) | |
| 13. | OC Tours (10) | 0–3 | USM Montargis (5) | |
| 14. | AS Tréon (12) | 1–1 | SMOC Saint-Jean-de-Braye (8) | |
| 15. | CA Pithiviers (6) | 0–2 | ES Chaingy-Saint-Ay (7) | |
| 16. | Amicale de Lucé (8) | 0–2 | J3S Amilly (5) | |
| 17. | ES Vallée Verte (9) | 1–0 | US Chitenay-Cellettes (8) | |
| 18. | Dammarie Foot Bois-Gueslin (8) | 3–1 | Saint-Georges Descartes (8) | |
| 19. | USM Olivet (7) | 0–15 | Avoine OCC (5) | |
| 20. | US Chambray-lès-Tours (6) | 5–1 | FCM Ingré (7) | |
| 21. | US Portugaise Joué-lès-Tours (7) | 2–4 | CS Mainvilliers (7) | |
| 22. | ÉB Saint-Cyr-sur-Loire (6) | 1–0 | USM Saran (5) | |
| 23. | ES Maintenon-Pierres (8) | 0–2 | FC Saint-Georges-sur-Eure (6) | |
| 24. | Olympique Portugais Mehun-sur-Yèvre (9) | 1–5 | Tours FC (5) |
These matches were played on 3 and 4 October 2020.[12]
| Tie no | Home team (tier) | Score | Away team (tier) | |
|---|---|---|---|---|
| 1. | FC Saint-Georges-sur-Eure (6) | 0–3 | Saint-Pryvé Saint-Hilaire FC (4) | |
| 2. | Blois Football 41 (4) | 0–1 | J3S Amilly (5) | |
| 3. | Dammarie Foot Bois-Gueslin (8) | 1–3 | FC Drouais (6) | |
| 4. | US Chambray-lès-Tours (6) | 0–1 | USM Montargis (5) | |
| 5. | ES Chaingy-Saint-Ay (7) | 0–6 | Avoine OCC (5) | |
| 6. | C'Chartres Football (4) | 2–2 | FC Montlouis (5) | |
| 7. | SMOC Saint-Jean-de-Braye (8) | 1–1 | ÉB Saint-Cyr-sur-Loire (6) | |
| 8. | ES Vallée Verte (9) | 0–1 | CS Mainvilliers (7) | |
| 9. | US Yzeures-Preuilly (9) | 2–2 | Bourges Foot (4) | |
| 10. | SA Issoudun (9) | 0–1 | SO Romorantin (4) | |
| 11. | ASL Orchaise (9) | 0–3 | Tours FC (5) | |
| 12. | Vierzon FC (5) | 1–0 | US Châteauneuf-sur-Loire (5) | |
| 13. | SC Massay (7) | 0–9 | Bourges 18 (4) | |
| 14. | ASPO Tours (11) | 1–1 | AS Saint-Amandoise (6) | |
| 15. | AS Portugais Bourges (6) | 1–3 | FC Déolois (5) |
These matches were played on 17 and 18 October 2020, with one postponed until 28 October 2020.[13]
| Tie no | Home team (tier) | Score | Away team (tier) | |
|---|---|---|---|---|
| 1. | CS Mainvilliers (7) | 0–1 | Tours FC (5) | |
| 2. | FC Drouais (6) | 0–2 | SO Romorantin (4) | |
| 3. | FC Montlouis (5) | 0–0 | US Orléans (3) | |
| 4. | Bourges Foot (4) | 2–0 | Saint-Pryvé Saint-Hilaire FC (4) | |
| 5. | FC Déolois (5) | 1–1 | USM Montargis (5) | |
| 6. | Vierzon FC (5) | 0–0 | Avoine OCC (5) | |
| 7. | SMOC Saint-Jean-de-Braye (8) | 3–3 | J3S Amilly (5) | |
| 8. | AS Saint-Amandoise (6) | 0–2 | Bourges 18 (4) |
These matches were played on 31 January 2021.[14]
| Tie no | Home team (tier) | Score | Away team (tier) | |
|---|---|---|---|---|
| 1. | Vierzon FC (5) | 1–2 | US Orléans (3) | |
| 2. | Bourges 18 (4) | 3–2 | Bourges Foot (4) | |
| 3. | SO Romorantin (4) | 3–1 | USM Montargis (5) | |
| 4. | SMOC Saint-Jean-de-Braye (8) | 1–2 | Tours FC (5) |