The 2020–21 CAF Confederation Cup knockout stage started on 16 May with the quarter-finals and will conclude on 10 July 2021 with the final to decide the champions of the 2020–21 CAF Confederation Cup. A total of eight teams are competing in the knockout stage.[1]
Times are GMT as listed by CAF (local times, even if not different, are in parentheses).
The schedule is as follows.
| Round | Draw date | First leg | Second leg |
|---|---|---|---|
| Quarter-finals | 30 April 2021 | 16 May 2021 | 23 May 2021 |
| Semi-finals | 20 June 2021 | 27 June 2021 | |
| Final | 10 July 2021 | ||
Each tie in the knockout stage, apart from the final, is played over two legs, with each team playing one leg at home. The team that scores more goals on aggregate over the two legs advances to the next round. If the aggregate score is level, the away goals rule is applied, i.e. the team that scores more goals away from home over the two legs advances. If away goals are also equal, then extra time is not played and the winners are decided by a penalty shoot-out. In the final, which is played as a single match, if the score is level at the end of normal time, extra time won't also be played and the winners will be decided by a penalty shoot-out.[1] The mechanism of the draws for each round is as follows:
The knockout stage involves the 8 teams which qualify as winners and runners-up of each of the eight groups in the group stage.
| Group | width=200 | Winners | width=200 | Runners-up |
|---|---|---|---|---|
| A |  Enyimba | Orlando Pirates | ||
| B | JS Kabylie |  Coton Sport | ||
| C |  ASC Jaraaf |  CS Sfaxien | ||
| D |  Raja Casablanca |  Pyramids |
The bracket of the knockout stage is determined as follows:[1]
| Round | Matchups | |
|---|---|---|
| Quarter-finals | (Group winners host second leg, matchups decided by draw, teams from same group cannot play each other)
| |
| Semi-finals | (Matchups and order of legs decided by draw, between winners QF1, QF2, QF3, QF4)
| |
| Final | Winners SF1 and SF2 will face each other to decide the champions |
The draw for the quarter-finals was held on 30 April 2021.
The first legs were played on 16 May, and the second legs were played on 23 May 2021.|}
JS Kabylie won 2–1 on aggregate.----Raja Casablanca won 5–1 on aggregate.----Pyramids won 5–2 on aggregate.----2–2 on aggregate. Coton Sport won on away goals.
The draw for the semi-finals was held on 30 April 2021 (after the quarter-finals draw).
The first legs were played on 20 June, and the second legs were played on 27 June 2021.|}
0–0 on aggregate. Raja Casablanca won 5–4 on penalties. ----JS Kabylie won 5–1 on aggregate.
See main article: 2021 CAF Confederation Cup Final. The final was played on 10 July 2021 at Stade de l'Amitié, Cotonou.