The 2020–21 CAF Champions League knockout stage started on 14 May with the quarter-finals and concluded on 17 July 2021 with the final to decide the champions of the 2020–21 CAF Champions League. A total of eight teams competed in the knockout stage.[1]
Times are GMT as listed by CAF (local times, even if not different, are in parentheses).
The schedule is as follows.
| Round | Draw date | First leg | Second leg |
|---|---|---|---|
| Quarter-finals | 30 April 2021 | 14–15 May 2021 | 21–22 May 2021 |
| Semi-finals | 18–19 June 2021 | 25–26 June 2021 | |
| Final | 17 July 2021 | ||
Each tie in the knockout stage, apart from the final, is played over two legs, with each team playing one leg at home. The team that scores more goals on aggregate over the two legs advances to the next round. If the aggregate score is level, the away goals rule is applied, i.e. the team that scores more goals away from home over the two legs advances. If away goals are also equal, then extra time is not played and the winners are decided by a penalty shoot-out. In the final, which is played as a single match, if the score is level at the end of normal time, extra time won't also be played and the winners will be decided by a penalty shoot-out.[1] The mechanism of the draws for each round is as follows:
The knockout stage involves the 8 teams which qualify as winners and runners-up of each of the eight groups in the group stage.
| Group | width=200 | Winners | width=200 | Runners-up |
|---|---|---|---|---|
| A | Simba |  Al Ahly | ||
| B | Mamelodi Sundowns | CR Belouizdad | ||
| C |  Wydad AC | Kaizer Chiefs | ||
| D |  Espérance de Tunis | MC Alger |
The bracket of the knockout stage is determined as follows:[1]
| Round | Matchups | |
|---|---|---|
| Quarter-finals | (Group winners host second leg, matchups decided by draw, teams from same group cannot play each other)
| |
| Semi-finals | (Matchups and order of legs decided by draw, between winners QF1, QF2, QF3, QF4)
| |
| Final | Winners SF1 and SF2 will face each other to decide the champions |
The draw for the quarter-finals was held on 30 April 2021.
The first legs were played on 14 and 15 May, and the second legs were played on 22 May 2021.|}
Al Ahly won 3–1 on aggregate.----Wydad AC won 2–1 on aggregate.----2–2 on aggregate. Espérance de Tunis won 3–2 on penalties. ----Kaizer Chiefs won 4–3 on aggregate.
The draw for the semi-finals was held on 30 April 2021 (after the quarter-finals draw).
The first legs were played on 19 June, and the second legs were played on 26 June 2021.|}
Kaizer Chiefs won 1–0 on aggregate.----Al Ahly won 4–0 on aggregate.
See main article: 2021 CAF Champions League Final. The final will be played on 17 July 2021 at Stade Mohammed V, Casablanca.