| Club: | Santa Clara |
| Season: | 2020–21 |
| Chrtitle: | President |
| Chairman: | Rui Miguel Melo Cordeiro |
| Mgrtitle: | Manager |
| Manager: | Daniel Ramos |
| Stadium: | Estádio de São Miguel |
| League: | Primeira Liga |
| League Result: | 6th |
| Cup1: | Taça de Portugal |
| Cup1 Result: | Quarter-finals |
| Pattern La1: | _santaclara2021h |
| Pattern B1: | _santaclara2021h |
| Pattern Ra1: | _santaclara2021h |
| Leftarm1: | FF0000 |
| Body1: | FF0000 |
| Rightarm1: | FF0000 |
| Shorts1: | FFFFFF |
| Socks1: | FF0000 |
| Pattern La2: | _santaclara2021a |
| Pattern B2: | _santaclara2021a |
| Pattern Ra2: | _santaclara2021a |
| Leftarm2: | 000000 |
| Body2: | DCBE64 |
| Rightarm2: | 000000 |
| Shorts2: | 000000 |
| Socks2: | 000000 |
| Pattern La3: | _santaclara2021t |
| Pattern B3: | _santaclara2021t |
| Pattern Ra3: | _santaclara2021t |
| Leftarm3: | FFFFFF |
| Body3: | FFFFFF |
| Rightarm3: | FFFFFF |
| Shorts3: | FF0000 |
| Socks3: | FFFFFF |
| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 season was the 100th season in the existence of C.D. Santa Clara and the club's third consecutive season in the top-flight of Portuguese football. In addition to the domestic league, Santa Clara participated in this season's edition of the Taça de Portugal.
See main article: 2020–21 Primeira Liga.
The league fixtures were announced on 28 August 2020.[1]
See main article: 2020–21 Taça de Portugal.