| Club: | Pisa |
| Chairman: | Giuseppe Corrado |
| Manager: | Luca D'Angelo |
| Stadium: | Arena Garibaldi |
| League: | Serie B |
| League Result: | 14th |
| Cup1: | Coppa Italia |
| Cup1 Result: | Third round |
| Pattern La1: | _pisa2021h |
| Pattern B1: | _pisa2021h |
| Pattern Ra1: | _pisa2021h |
| Pattern Sh1: | _pisa2021h |
| Pattern So1: | _pisa1920h |
| Leftarm1: | 000000 |
| Body1: | 0000FF |
| Rightarm1: | 000000 |
| Shorts1: | 000000 |
| Socks1: | 000000 |
| Pattern La2: | _pisa2021a |
| Pattern B2: | _pisa2021a |
| Pattern Ra2: | _pisa2021a |
| Pattern Sh2: | _pisa2021a |
| Pattern So2: | _pisa2021a |
| Leftarm2: | FFFFFF |
| Body2: | FFFFFF |
| Rightarm2: | FFFFFF |
| Shorts2: | FFFFFF |
| Socks2: | FFFFFF |
| Pattern La3: | _adidasregista20gw |
| Pattern B3: | _adidasregista20gw |
| Pattern Ra3: | _adidasregista20gw |
| Pattern Sh3: | _striped19green |
| Pattern So3: | _color_3_stripes_white |
| Leftarm3: | 008000 |
| Body3: | 008000 |
| Rightarm3: | 008000 |
| Shorts3: | 008000 |
| Socks3: | 008000 |
| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 season was A.C. Pisa 1909's second consecutive season in second division of the Italian football league, the Serie B, and the 112th as a football club.
See main article: 2020–21 Serie B.
See main article: 2020–21 Coppa Italia.