| Competition: | 2. Liga |
| Season: | 2020–21 |
| Winners: | MFK Tatran Liptovský Mikuláš |
| Promoted: | MFK Tatran Liptovský Mikuláš |
| Relegated: | FK Poprad |
| League Topscorer: | Wisdom Kanu (18) |
| Prevseason: | 2019–20 |
| Nextseason: | 2021–22 |
The 2020–21 2. Liga is the 28th season of the 2. Liga in Slovakia, since its establishment in 1993.
| Team | Location | Stadium | Capacity |
|---|---|---|---|
| Železiarne Podbrezová | Podbrezová | ZELPO Aréna | 4,061 |
| MFK Skalica | Skalica | Mestský štadión Skalica | 1,500 |
| FK Dubnica | Dubnica nad Váhom | Mestský futbalový štadión | 5,450 |
| MFK Dukla Banská Bystrica | Banská Bystrica | MFK Zvolen Stadium | 9,881 |
| FC Petržalka | Petržalka | Štadión FC Petržalka | 1,600 |
| FK Poprad | Poprad | NTC Poprad | 5,070 |
| MŠK Žilina B | Žilina | Štadión pod Dubňom | 11,258 |
| KFC Komárno | Komárno | Mestský štadión Komárno | 1,250 |
| FC ŠTK 1914 Šamorín | Šamorín | Pomlé Stadium | 1,950 |
| MFK Tatran Liptovský Mikuláš | Liptovský Mikuláš | Stadium Liptovský Mikuláš | 1,950 |
| Partizán Bardejov | Bardejov | Mestský štadión Bardejov | 3,040 |
| FK Slavoj Trebišov | Trebišov | Štadión Slavoj Trebišov | 2,000 |
| Slovan Bratislava U21[1] | Bratislava | Štadión Pasienky | 11,401 |
| MŠK Púchov | Púchov | Mestský štadión Púchov | 6,614 |
| FC Košice | Košice | Štadión Lokomotívy | 9,000 |
Note: Flags indicate national team as has been defined under FIFA eligibility rules. Players and Managers may hold more than one non-FIFA nationality.
| Team | Head coach | Captain | Kit manufacturer | Shirt sponsor |
|---|---|---|---|---|
| MFK Skalica |  Jozef Kostelník | Martin Nagy | Puma | - |
| FK Slavoj Trebišov | Ondrej Desiatnik | Tomáš Ilinjo | Adidas | Armstav |
| FK Poprad | Stanislav Ďuriš | Matej Grešák | Adidas | Ritro |
| MŠK Žilina B | Norbert Gula | Adam Kopas |  Nike | Preto |
| KFC Komárno | Szilárd Németh | Kristóf Domonkos | Adidas | MOL |
| MFK Tatran Liptovský Mikuláš | Marek Petruš | Richard Bartoš |  Sportika SA | Verex |
| Partizán Bardejov |  Hajrudin Nuhic | Ján Čikoš-Pavličko | Adidas | SETL SK |
| FC Petržalka | Ladislav Pecko | Boris Turčák | Erreà | - |
| FC ŠTK 1914 Šamorín | Ján Blaháč | Ľubomír Mezovský | Kappa | Slovnaft |
| FK Dubnica | Peter Jakuš | Dalibor Pleva | Adidas | - |
| MFK Dukla Banská Bystrica | Stanislav Varga | Róbert Polievka | Adidas | Veolia |
| Slovan Bratislava U21 | Stanislav Moravec | TBA | Adidas | grafobal |
| MŠK Púchov | Lukáš Kaplan | František Brezničan | Jako | - |
| FC Košice | Jozef Vukušič | František Vancák | Adidas | BMW Regnum Košice |
| Podbrezová | Mikuláš Radványi | Erik Grendel | Adidas | Železiarne Podbrezová |
Each team plays home-and-away against every other team in the league, for a total of 28 matches each.
| Rank | Player | Club | Goals[2] |
|---|---|---|---|
| 1 |  Wisdom Kanu | Trebišov | 18 |
| 2 | Daniel Šebesta | Skalica | 17 |
 Miladin Vujošević | Banská Bystrica | ||
| 4 | Richard Bartoš | Liptovský Mikuláš | 15 |
| 5 | Martin Rymarenko | Šamorín | 14 |
| 6 | Róbert Polievka | Banská Bystrica | 13 |
| 7 | Lukáš Gašparovič | Petržalka | 12 |
| 8 | Roland Galčík | Podbrezová | 11 |
| 9 | Michal Ranko | Skalica | 10 |
| Daniel Pavúk | Podbrezová | ||
| 10 | Usman Adekunle Issa | Trebišov | 9 |
| Taofiq Jibril | Žilina B | ||
Source:[3]
Matúš Kira (FC Košice) František Pavúk (FC Košice), Boris Godál (Podbrezová), Michal Ranko (MFK Skalica), Lukáš Migaľa (Banská Bystrica) Erik Grendel (Podbrezová), Richard Bartoš (Liptovský Mikuláš), Wisdom Kanu (FK Slavoj Trebišov) Daniel Šebesta (MFK Skalica), Roland Galčík (Podbrezová), Róbert Polievka (Banská Bystrica)Manager of the season
Stanislav Varga (Banská Bystrica)
Player of the Year
Róbert Polievka (Banská Bystrica)
Young player of the Year