| Champ: | Aniek van Koot |
| Runner: | Diede de Groot |
| Score: | 6–4, 4–6, 7–5 |
| After Year: | 2021 |
See main article: 2019 Wimbledon Championships.
Aniek van Koot defeated the two-time defending champion Diede de Groot in the final, 6–4, 4–6, 7–5 to win the ladies' singles wheelchair tennis title at the 2019 Wimbledon Championships. It was de Groot's only loss at the majors that year, preventing her from achieving the Grand Slam; as of 2023, it also remains as de Groot's only defeat at Wimbledon.