| Champ: |  Kirsten Flipkens |
| Runner: |  CoCo Vandeweghe |
| Score: | 7–6(7–4), 6–4 |
| Edition: | 2nd |
| Before Name: | Oracle Challenger Series – Houston – Women's Singles |
| After Name: | Oracle Challenger Series – Houston – Women's Singles |
See main article: article and 2019 Oracle Challenger Series – Houston.
Peng Shuai was the defending champion, but chose to compete in an ITF event in Tokyo instead.
Kirsten Flipkens won the title, defeating CoCo Vandeweghe in the final, 7–6(7–4), 6–4. Flipkens beat five American players in five matches on the way to her first WTA 125K series title.
All seeds received a bye into the second round.