The 2019 Open Sopra Steria de Lyon was a professional tennis tournament played on clay courts. It was the 4th edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Lyon, France, between 10 and 16 June 2019.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Albert Ramos Viñolas | 87 | 1 | |
| Spain | Pablo Andújar | 93 | 2 | |
 France | Corentin Moutet | 110 | 3 | |
 Sweden | Elias Ymer | 115 | 4 | |
| Pedro Sousa | 124 | 5 | ||
| Spain | Pedro Martínez | 134 | 6 | |
 Italy | ||||
| France | Quentin Halys | 151 | 8 | |
| Spain | Enrique López Pérez | 166 | 9 | |
| Rudolf Molleker | 173 | 10 | ||
 Belgium | Kimmer Coppejans | 178 | 11 | |
| Belgium | Arthur De Greef | 181 | 12 | |
| France | Maxime Janvier | 190 | 13 | |
| France | Constant Lestienne | 192 | 14 | |
 Colombia | Daniel Elahi Galán | 197 | 15 | |
| Tallon Griekspoor | 198 | 16 |
The following players received wildcards into the singles main draw:
Antoine Cornut-Chauvinc Hugo Gaston Manuel Guinard Matteo MartineauThe following player received entry into the singles main draw as a special exempt:
The following players received entry into the singles main draw as alternates:
The following players received entry into the singles main draw using their ITF World Tennis Ranking:
Corentin Denolly Eduard Esteve Lobato Oriol Roca BatallaThe following players received entry from the qualifying draw:
The following player received entry as a lucky loser:
See main article: 2019 Open Sopra Steria de Lyon – Singles.
Corentin Moutet def. Elias Ymer 6–4, 6–4.See main article: 2019 Open Sopra Steria de Lyon – Doubles.
Philipp Oswald / 
Filip Polášek def. Simone Bolelli / Andrea Pellegrino 6–4, 7–6(7–2).