| Champ: | Kiki Bertens |
| Runner: |  Simona Halep |
| Score: | 6–4, 6–4 |
| Draw: | 64 (8 / 5) |
| Seeds: | 16 |
| After Year: | 2021 |
See main article: 2019 Mutua Madrid Open.
Kiki Bertens defeated Simona Halep in the final, 6–4, 6–4 to win the women's singles tennis title at the 2019 Madrid Open. She became the first player to win the title without losing a set en route.
Petra Kvitová was the defending champion,[1] but lost to Bertens in the quarterfinals in a rematch of the previous year's final.
Naomi Osaka, Halep and Angelique Kerber were in contention for the WTA no. 1 singles ranking at the beginning of the tournament. Osaka retained the ranking following Kerber's withdrawal in the second round, and Halep's subsequent defeat in the final.[2]